(2E,4R)-4-[(1R,3aS,4E,7aR)-4-[(2E)-2-[(3S,5R)-3,5-Bis[[(tert-butyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-cyclopropyl-2-penten-1-one
医药中间体
医药中间体保密等级：公开
- INN / 通用名
- (2E,4R)-4-[(1R,3aS,4E,7aR)-4-[(2E)-2-[(3S,5R)-3,5-Bis[[(tert-butyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-cyclopropyl-2-penten-1-one
- CAS 号
- 112849-17-9
- 当前状态
- 官方中间体目录（API: Calcipotriol）
- MOQ
- 询价
- 交期
- 询价
- 价格区间
- 询价
剂型与注册相关字段（API / 制剂向，点开展开）
- 剂型
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- 规格
- —
- 治疗领域
- Pharmaceutical Intermediates
- 适应症
- API: Calcipotriol
- GMP 资质
- —
- CEP
- 无
- DMF 类型
- —
- 稳定性数据
- —
- 是否需 BE
- 不需要 / 可豁免
- 注册路径
- FSO 供货（非注册物质）
海关编码（HS Code）
2931.90有机金属化合物(281)站内有 281 票该编码的海关提运单
可注册市场
Global
工艺 / 序列 / 精确价格
- 工艺简述
- 倍他米松二丙酸酯/卡泊三醇（Betamethasone Dipropionate/Calcipotriol）原研路线 Route 1（15 步）的第 11 个中间体（路线编号 CALCIP-011）。同路线原料/中间体：(S,Z)-3-((E)-2-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexanol、(6S)-1-((E)-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)methyl)-6-hydroxy-1,3,4,5,6,7-hexahydrobenzo[c]thiophene 2,2-dioxide、2-((1R,3aS,7aR,E)-4-(((6S)-6-((tert-butyldimethylsilyl)oxy)-2,2-dioxido-1,3,4,5,6,7-hexahydrobenzo[c]thiophen-1-yl)methylene)-7a-methyloctahydro-1H-inden-1-yl)propanal、tert-butyl(((S,E)-3-((E)-2-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexyl)oxy)dimethylsilane、(1S,5R,E)-5-((tert-butyldimethylsilyl)oxy)-3-((E)-2-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-2-methylenecyclohexanol、(((1R,3S,E)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diyl)bis(oxy))bis(tert-butyldimethylsilane)、(4S,6R)-4,6-bis((tert-butyldimethylsilyl)oxy)-1-((E)-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)methyl)octahydrobenzo[c]thiophene 2,2-dioxide、(2S)-2-((1R,3aS,7aR,E)-4-(((4S,6R)-4,6-bis((tert-butyldimethylsilyl)oxy)-2,2-dioxidooctahydrobenzo[c]thiophen-1-yl)methylene)-7a-methyloctahydro-1H-inden-1-yl)propanal。来源：药渡路线数据（站内 patent-cliff 库）；完整步序可查 SciFinder / 谷歌专利。合成路线由站内药渡路线数据自动补齐——完整步序建议再对 SciFinder / 谷歌专利核一遍。
- 精确价格
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