2-Fluoro-6-methoxyphenylboronic acid

INN / 通用名

2-Fluoro-6-methoxyphenylboronic acid

CAS 号

78495-63-3

当前状态

官方中间体目录（API: Sotorasib）

MOQ

询价

交期

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价格区间

询价

工艺 / 序列 / 精确价格

工艺简述

氟泽雷塞（Fulzerasib）原研路线 Route 1（7 步）的第 4 个中间体（路线编号 (IV)1225102-1-a）。同路线原料/中间体：6,7-Dichloro-1,2-dihydro-4-hydroxy-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-2-oxo-1,8-naphthyridine-3-carbonitrile、6,7-Dichloro-4-hydroxy-1-(2-isopropyl-4-methyl-3-pyridyl)-1,8-naphthyridin-2-one、6,7-Dichloro-4-hydroxy-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-3-nitro-1,8-naphthyridin-2(1H)-one、6-Chloro-7-(2-fluoro-6-methoxyphenyl)-4-hydroxy-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-3-nitro-1,8-naphthyridin-2(1H)-one、4,6-Dichloro-7-(2-fluoro-6-methoxyphenyl)-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-3-nitro-1,8-naphthyridin-2(1H)-one、(R)-Piperazine-1,3-dicarboxylic acid 1-tert-butyl 3-methyl diester、1-tert-Butyl 3-methyl (3R)-4-[6-chloro-7-(2-fluoro-6-methoxyphenyl)-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-3-nitro-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl]piperazine-1,3-dicarboxylate、tert-Butyl (4aR)-11-chloro-10-(2-fluoro-6-methoxyphenyl)-8-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-5,7-dioxo-1,2,4,4a,5,6,7,8-octahydro-3H-pyrazino[1',2':4,5]pyrazino[2,3-c][1,8]naphthyridine-3-carboxylate。来源：药渡路线数据（站内 patent-cliff 库）；完整步序可查 SciFinder / 谷歌专利。

合成路线由站内药渡路线数据自动补齐——完整步序建议再对 SciFinder / 谷歌专利核一遍。

精确价格

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