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Voclosporin
Tier C — Watch / tradeVoclosporin
Aurinia
Originator
2021
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：Calcineurin
Brand：Luveniq, Voclera, Orelvo, Lupkynis
Indications (approved)：狼疮肾炎
Regional status
US
Approved
2021-01-22
EU
Approved
2022-09-15
China
Phase III
2013-10-21
Japan
Approved
2024-09-24
Synthetic routes & intermediates6 routes
Originator routes × 0Optimised (non-patent) × 6Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 2 · Total yield /
Voclosporin-00159865-13-3Voclosporin-002—Voclosporin-003—Voclosporin-004121584-52-9Voclosporin-005—API · Voclosporin
| Code | CAS No. | Intermediate |
|---|---|---|
| Voclosporin-001 | 59865-13-3 | Cyclo{-[4-( E)-but-2-enyl- N,4-dimethyl- L-threonyl]-L-homoalanyl-(N-methylglycyl)-( N-methyl-L-leucyl)-L-valyl-( N-me-thyl- L-leucyl)-L-alanyl- D-alanyl-(N-methyl-L-leucyl)-( N-methyl-L-leucyl)-(N-methyl-L-valyl)-} |
| Voclosporin-002 | - | (1R,2R,4E)-1-[(2S,5S,11S,14S,17S,20S,23R,26S,29S,32S)-5-Ethyl-1,7,10,16,20,23,25,28,31-nonamethyl-11,17,26,29-tetrakis(2-methylpropyl)-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-14,32-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2-yl]-2-methylhex-4-en-1-ylacetate |
| Voclosporin-003 | - | (1R,2R,4E)-1-[(2S,5S,11S,14S,17S,20S,23R,26S,29S,32S)-5-Ethyl-1,7,10,16,20,23,25,28,31-nonamethyl-11,17,26,29-tetrakis(2-methylpropyl)-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-14,32-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2-yl]-2-methylhex-4-en-1-ylbenzoate |
| Voclosporin-004 | 121584-52-9 | Cyclo[[3(R)-acetoxy-N2,4(R)-dimethyl-6-oxo-L-norleucyl]-L-2-aminobutyryl-N-methyl-G-N-methyl-LV-N-methyl-LAa-N-methyl-L-N-methyl-L-N-methyl-V] |
| Voclosporin-005 | - | (1R,2R)-1-[(2S,5S,11S,14S,17S,20S,23R,26S,29S,32S)-5-Ethyl-1,7,10,16,20,23,25,28,31-nonamethyl-11,17,26,29-tetrakis(2-methylpropyl)-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-14,32-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2-yl]-2-methyl-4-oxobutylbenzoate |
OptimisedRoute 2Steps 2 · Total yield 9.6g(Voclosporin (Free))
Voclosporin-004121584-52-9Voclosporin-005—Voclosporin-006—Voclosporin-007515814-02-5Voclosporin-008—Voclosporin-009—Voclosporin-010—API · Voclosporin
| Code | CAS No. | Intermediate |
|---|---|---|
| Voclosporin-004 | 121584-52-9 | Cyclo[[3(R)-acetoxy-N2,4(R)-dimethyl-6-oxo-L-norleucyl]-L-2-aminobutyryl-N-methyl-G-N-methyl-LV-N-methyl-LAa-N-methyl-L-N-methyl-L-N-methyl-V] |
| Voclosporin-005 | - | (1R,2R)-1-[(2S,5S,11S,14S,17S,20S,23R,26S,29S,32S)-5-Ethyl-1,7,10,16,20,23,25,28,31-nonamethyl-11,17,26,29-tetrakis(2-methylpropyl)-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-14,32-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2-yl]-2-methyl-4-oxobutylbenzoate |
| Voclosporin-006 | - | Triphenyl(prop-2-en-1-yl)phosphoniumbromide |
| Voclosporin-007 | 515814-02-5 | (1R,2R,4E)-1-[(2S,5S,11S,14S,17S,20S,23R,26S,29S,32S)-5-Ethyl-1,7,10,16,20,23,25,28,31-nonamethyl-11,17,26,29-tetrakis(2-methylpropyl)-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-14,32-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2-yl]-2-methylhepta-4,6-dien-1-ylacetate |
| Voclosporin-008 | - | (1R,2R,4E)-1-[(2S,5S,11S,14S,17S,20S,23R,26S,29S,32S)-5-Ethyl-1,7,10,16,20,23,25,28,31-nonamethyl-11,17,26,29-tetrakis(2-methylpropyl)-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-14,32-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2-yl]-2-methylhepta-4,6-dien-1-ylbenzoate |
| Voclosporin-009 | - | [Phenyl(prop-2-en-1-yl)phosphoroso]benzene |
| Voclosporin-010 | - | Dimethylallylphosphonate |
OptimisedRoute 3Steps 3 · Total yield 10.51g(Voclosporin (Free))
Voclosporin-011603-35-0Voclosporin-002—Voclosporin-012138957-22-9Voclosporin-013514854-23-0API · Voclosporin
| Code | CAS No. | Intermediate |
|---|---|---|
| Voclosporin-011 | 603-35-0 | Phosphorustriphenyl |
| Voclosporin-002 | - | (1R,2R,4E)-1-[(2S,5S,11S,14S,17S,20S,23R,26S,29S,32S)-5-Ethyl-1,7,10,16,20,23,25,28,31-nonamethyl-11,17,26,29-tetrakis(2-methylpropyl)-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-14,32-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2-yl]-2-methylhex-4-en-1-ylacetate |
| Voclosporin-012 | 138957-22-9 | (1R,2R,4E)-6-bromo-1-[(2S,5S,11S,14S,17S,20S,23R,26S,29S,32S)-5-ethyl-1,7,10,16,20,23,25,28,31-nonamethyl-11,17,26,29-tetrakis(2-methylpropyl)-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-14,32-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2-yl]-2-methylhex-4-en-1-ylacetate |
| Voclosporin-013 | 514854-23-0 | [(2E,5R,6R)-6-(acetyloxy)-6-[(2S,5S,11S,14S,17S,20S,23R,26S,29S,32S)-5-ethyl-1,7,10,16,20,23,25,28,31-nonamethyl-11,17,26,29-tetrakis(2-methylpropyl)-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-14,32-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2-yl]-5-methylhex-2-en-1-yl]triphenylphosphoniumbromide |
OptimisedRoute 4Steps 2 · Total yield 14.09g(Voclosporin (Free))
Voclosporin-004121584-52-9Voclosporin-01479309-68-5Voclosporin-015—API · Voclosporin
| Code | CAS No. | Intermediate |
|---|---|---|
| Voclosporin-004 | 121584-52-9 | Cyclo[[3(R)-acetoxy-N2,4(R)-dimethyl-6-oxo-L-norleucyl]-L-2-aminobutyryl-N-methyl-G-N-methyl-LV-N-methyl-LAa-N-methyl-L-N-methyl-L-N-methyl-V] |
| Voclosporin-014 | 79309-68-5 | trimethyl[(1E)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)prop-1-en-1-yl]silane |
| Voclosporin-015 | - | (1R,2R,4R,5R)-1-[(2S,5S,11S,14S,17S,20S,23R,26S,29S,32S)-5-ethyl-14,32-diisopropyl-1,7,10,16,20,23,25,28,31-nonamethyl-11,17,26,29-tetrakis(2-methylpropyl)-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2-yl]-4-hydroxy-2-methyl-5-(trimethylsilyl)hept-6-en-1-ylacetate |
OptimisedRoute 5Steps 2 · Total yield 4.92g(Voclosporin-004)
Voclosporin-00159865-13-3Voclosporin-002—Voclosporin-004121584-52-9API · Voclosporin
| Code | CAS No. | Intermediate |
|---|---|---|
| Voclosporin-001 | 59865-13-3 | Cyclo{-[4-( E)-but-2-enyl- N,4-dimethyl- L-threonyl]-L-homoalanyl-(N-methylglycyl)-( N-methyl-L-leucyl)-L-valyl-( N-me-thyl- L-leucyl)-L-alanyl- D-alanyl-(N-methyl-L-leucyl)-( N-methyl-L-leucyl)-(N-methyl-L-valyl)-} |
| Voclosporin-002 | - | (1R,2R,4E)-1-[(2S,5S,11S,14S,17S,20S,23R,26S,29S,32S)-5-Ethyl-1,7,10,16,20,23,25,28,31-nonamethyl-11,17,26,29-tetrakis(2-methylpropyl)-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-14,32-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2-yl]-2-methylhex-4-en-1-ylacetate |
| Voclosporin-004 | 121584-52-9 | Cyclo[[3(R)-acetoxy-N2,4(R)-dimethyl-6-oxo-L-norleucyl]-L-2-aminobutyryl-N-methyl-G-N-methyl-LV-N-methyl-LAa-N-methyl-L-N-methyl-L-N-methyl-V] |
OptimisedRoute 6Steps 2 · Total yield 40mg(Voclosporin (Free))
Voclosporin-004121584-52-9Voclosporin-01613361-64-3Voclosporin-007515814-02-5API · Voclosporin
| Code | CAS No. | Intermediate |
|---|---|---|
| Voclosporin-004 | 121584-52-9 | Cyclo[[3(R)-acetoxy-N2,4(R)-dimethyl-6-oxo-L-norleucyl]-L-2-aminobutyryl-N-methyl-G-N-methyl-LV-N-methyl-LAa-N-methyl-L-N-methyl-L-N-methyl-V] |
| Voclosporin-016 | 13361-64-3 | 3-(Trimethylsilyl)propyne |
| Voclosporin-007 | 515814-02-5 | (1R,2R,4E)-1-[(2S,5S,11S,14S,17S,20S,23R,26S,29S,32S)-5-Ethyl-1,7,10,16,20,23,25,28,31-nonamethyl-11,17,26,29-tetrakis(2-methylpropyl)-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-14,32-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2-yl]-2-methylhepta-4,6-dien-1-ylacetate |
Frequently asked questions
What are the approved indications of Voclosporin?
Approved indications include: 狼疮肾炎.
When does the Voclosporin patent expire?
No public expiry year is available for Voclosporin yet; this page updates once verified.
How many synthesis routes are recorded for Voclosporin?
6 synthesis routes are recorded; the shortest is 2 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Voclosporin intermediates?
All intermediates in Voclosporin routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Voclosporin intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-10-22