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Lutetium (177Lu) vipivotide tetraxetan
Tier B — Position earlyLutetium (177Lu) vipivotide tetraxetan
Radiomedix Inc
Originator
2022
First approval
-
Expiry (public)
$1.99B ▲
Peak sales
-
Type
Targets：PSMA
Brand：PLUVICTO
Indications (approved)：Hormone-sensitive prostate cancer, Castration-resistant prostate cancer, Prostate cancer
Regional status
US
Approved
2022-03-23
EU
Approved
2022-12-09
China
Approved
2025-11-04
Japan
Approved
2025-09-19
Synthetic routes & intermediates7 routes
Originator routes × 0Optimised (non-patent) × 7Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 8 · Total yield /
Lutetium (177Lu) vipivotide tetraxetan-00132677-01-3Lutetium (177Lu) vipivotide tetraxetan-00216874-06-9Lutetium (177Lu) vipivotide tetraxetan-003180839-17-2Lutetium (177Lu) vipivotide tetraxetan-004—Lutetium (177Lu) vipivotide tetraxetan-005—Lutetium (177Lu) vipivotide tetraxetan-006—Lutetium (177Lu) vipivotide tetraxetan-007—Lutetium (177Lu) vipivotide tetraxetan-008112883-43-9Lutetium (177Lu) vipivotide tetraxetan-009—Lutetium (177Lu) vipivotide tetraxetan-010—Lutetium (177Lu) vipivotide tetraxetan-011—Lutetium (177Lu) vipivotide tetraxetan-012137076-54-1Lutetium (177Lu) vipivotide tetraxetan-0131702967-37-0Lutetium (177Lu) vipivotide tetraxetan-014146982-27-6Lutetium (177Lu) vipivotide tetraxetan-015—API · Lutetium (177Lu) vipivotide tetraxetan
| Code | CAS No. | Intermediate |
|---|---|---|
| Lutetium (177Lu) vipivotide tetraxetan-001 | 32677-01-3 | L-Glutamic acid di-tert-butyl ester hydrochloride |
| Lutetium (177Lu) vipivotide tetraxetan-002 | 16874-06-9 | L-Glutamic acid di(tert-butyl) ester |
| Lutetium (177Lu) vipivotide tetraxetan-003 | 180839-17-2 | Di-tert-butyl 2(S)-isocyanatopentanedioate |
| Lutetium (177Lu) vipivotide tetraxetan-004 | - | Di-tert-butyl N-[(trichloromethoxy)carbonyl]-L-glutamate |
| Lutetium (177Lu) vipivotide tetraxetan-005 | - | Resin bound H-Lys(Alloc)-OH |
| Lutetium (177Lu) vipivotide tetraxetan-006 | - | Resin bound (2S)-2-([[(2S)-1,5-di-tert-butoxy-1,5-dioxopentan-2-yl]carbamoyl]amino)-6-([[(prop-2-en-1-yl)oxy]carbonyl]amino)hexanoic acid |
| Lutetium (177Lu) vipivotide tetraxetan-007 | - | Resin bound (2S)-6-amino-2-([[(2S)-1,5-di-tert-butoxy-1,5-dioxopentan-2-yl]carbamoyl]amino)hexanoic acid |
| Lutetium (177Lu) vipivotide tetraxetan-008 | 112883-43-9 | Fmoc-2-Nal-OH |
| Lutetium (177Lu) vipivotide tetraxetan-009 | - | Resin bound 6-[[(2S)-2-amino-3-(naphthalen-2-yl)propanoyl]amino]-2-([[(2S)-1,5-di-tert-butoxy-1,5-dioxopentan-2-yl]carbamoyl]amino)hexanoic acid |
| Lutetium (177Lu) vipivotide tetraxetan-010 | - | Fmoc-tranexamic acid |
| Lutetium (177Lu) vipivotide tetraxetan-011 | - | Resin bound (2S)-6-[[(2S)-2-[[(1r,4S)-4-(aminomethyl)cyclohexane-1-carbonyl]amino]-3-(naphthalen-2-yl)propanoyl]amino]-2-([[(2S)-1,5-di-tert-butoxy-1,5-dioxopentan-2-yl]carbamoyl]amino)hexanoic acid |
| Lutetium (177Lu) vipivotide tetraxetan-012 | 137076-54-1 | DOTA-Tris(t-Bu)ester |
| Lutetium (177Lu) vipivotide tetraxetan-013 | 1702967-37-0 | (3S,10S,14S)-3-[(Naphthalen-2-yl)methyl]-1,4,12-trioxo-1-[(1r,4S)-4-([2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetamido]methyl)cyclohexyl]-2,5,11,13-tetraazahexadecane-10,14,16-tricarboxylic acid |
| Lutetium (177Lu) vipivotide tetraxetan-014 | 146982-27-6 | N6-[(Allyloxy)carbonyl]-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-lysine |
| Lutetium (177Lu) vipivotide tetraxetan-015 | - | Resin bound N2-[[(9H-fluoren-9-yl)methoxy]carbonyl]-N6-[[(prop-2-en-1-yl)oxy]carbonyl]-L-lysine |
OptimisedRoute 2Steps 3 · Total yield /
Lutetium (177Lu) vipivotide tetraxetan-011—Lutetium (177Lu) vipivotide tetraxetan-0131702967-37-0Lutetium (177Lu) vipivotide tetraxetan-0162253751-88-9Lutetium (177Lu) vipivotide tetraxetan-017170908-81-3Lutetium (177Lu) vipivotide tetraxetan-018—API · Lutetium (177Lu) vipivotide tetraxetan
| Code | CAS No. | Intermediate |
|---|---|---|
| Lutetium (177Lu) vipivotide tetraxetan-011 | - | Resin bound (2S)-6-[[(2S)-2-[[(1r,4S)-4-(aminomethyl)cyclohexane-1-carbonyl]amino]-3-(naphthalen-2-yl)propanoyl]amino]-2-([[(2S)-1,5-di-tert-butoxy-1,5-dioxopentan-2-yl]carbamoyl]amino)hexanoic acid |
| Lutetium (177Lu) vipivotide tetraxetan-013 | 1702967-37-0 | (3S,10S,14S)-3-[(Naphthalen-2-yl)methyl]-1,4,12-trioxo-1-[(1r,4S)-4-([2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetamido]methyl)cyclohexyl]-2,5,11,13-tetraazahexadecane-10,14,16-tricarboxylic acid |
| Lutetium (177Lu) vipivotide tetraxetan-016 | 2253751-88-9 | (2S)-6-[[(2S)-2-[[(1r,4S)-4-(Aminomethyl)cyclohexane-1-carbonyl]amino]-3-(naphthalen-2-yl)propanoyl]amino]-2-([[(2S)-1,5-di-tert-butoxy-1,5-dioxopentan-2-yl]carbamoyl]amino)hexanoic acid |
| Lutetium (177Lu) vipivotide tetraxetan-017 | 170908-81-3 | 2,2',2''-(10-[2-[(2,5-Dioxopyrrolidin-1-yl)oxy]-2-oxoethyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid |
| Lutetium (177Lu) vipivotide tetraxetan-018 | - | (2S)-2-([[(2S)-1,5-Di-tert-butoxy-1,5-dioxopentan-2-yl]carbamoyl]amino)-6-[[(2S)-3-(naphthalen-2-yl)-2-[[(1r,4S)-4-([2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetamido]methyl)cyclohexane-1-carbonyl]amino]propanoyl]amino]hexanoic acid |
OptimisedRoute 3Steps 1 · Total yield /
Lutetium (177Lu) vipivotide tetraxetan-0131702967-37-0API · Lutetium (177Lu) vipivotide tetraxetan
| Code | CAS No. | Intermediate |
|---|---|---|
| Lutetium (177Lu) vipivotide tetraxetan-013 | 1702967-37-0 | (3S,10S,14S)-3-[(Naphthalen-2-yl)methyl]-1,4,12-trioxo-1-[(1r,4S)-4-([2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetamido]methyl)cyclohexyl]-2,5,11,13-tetraazahexadecane-10,14,16-tricarboxylic acid |
OptimisedRoute 4Steps 5 · Total yield 176mg(PSMA-617 (Free))
Lutetium (177Lu) vipivotide tetraxetan-019530-62-1Lutetium (177Lu) vipivotide tetraxetan-00132677-01-3Lutetium (177Lu) vipivotide tetraxetan-0201025796-29-5Lutetium (177Lu) vipivotide tetraxetan-021—Lutetium (177Lu) vipivotide tetraxetan-022—Lutetium (177Lu) vipivotide tetraxetan-023—Lutetium (177Lu) vipivotide tetraxetan-008112883-43-9Lutetium (177Lu) vipivotide tetraxetan-009—Lutetium (177Lu) vipivotide tetraxetan-010—Lutetium (177Lu) vipivotide tetraxetan-011—API · Lutetium (177Lu) vipivotide tetraxetan
| Code | CAS No. | Intermediate |
|---|---|---|
| Lutetium (177Lu) vipivotide tetraxetan-019 | 530-62-1 | 1,1-Bis(1H-imidazol-1-yl)methanone |
| Lutetium (177Lu) vipivotide tetraxetan-001 | 32677-01-3 | Di-tert-butyl L-glutamate hydrogen chloride |
| Lutetium (177Lu) vipivotide tetraxetan-020 | 1025796-29-5 | Di-tert-butyl N-(1H-imidazole-1-carbonyl)-L-glutamate |
| Lutetium (177Lu) vipivotide tetraxetan-021 | - | Resin bound Fmoc-L-Lys(ivDde) |
| Lutetium (177Lu) vipivotide tetraxetan-022 | - | Resin bound N6-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]-L-lysine |
| Lutetium (177Lu) vipivotide tetraxetan-023 | - | Resin bound (2S)-2-([[(2S)-1,5-di-tert-butoxy-1,5-dioxopentan-2-yl]carbamoyl]amino)-6-[[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]hexanoic acid |
| Lutetium (177Lu) vipivotide tetraxetan-008 | 112883-43-9 | Fmoc-2-Nal-OH |
| Lutetium (177Lu) vipivotide tetraxetan-009 | - | Resin bound 6-[[(2S)-2-amino-3-(naphthalen-2-yl)propanoyl]amino]-2-([[(2S)-1,5-di-tert-butoxy-1,5-dioxopentan-2-yl]carbamoyl]amino)hexanoic acid |
| Lutetium (177Lu) vipivotide tetraxetan-010 | - | (1r,4r)-4-[([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)methyl]cyclohexane-1-carboxylic acid |
| Lutetium (177Lu) vipivotide tetraxetan-011 | - | Resin bound (2S)-6-[[(2S)-2-[[(1r,4S)-4-(aminomethyl)cyclohexane-1-carbonyl]amino]-3-(naphthalen-2-yl)propanoyl]amino]-2-([[(2S)-1,5-di-tert-butoxy-1,5-dioxopentan-2-yl]carbamoyl]amino)hexanoic acid |
OptimisedRoute 5Steps 1 · Total yield 286mg(Lutetium (177Lu) vipivotide tetraxetan-013)
Lutetium (177Lu) vipivotide tetraxetan-011—Lutetium (177Lu) vipivotide tetraxetan-012137076-54-1Lutetium (177Lu) vipivotide tetraxetan-0131702967-37-0API · Lutetium (177Lu) vipivotide tetraxetan
| Code | CAS No. | Intermediate |
|---|---|---|
| Lutetium (177Lu) vipivotide tetraxetan-011 | - | Resin bound (2S)-6-[[(2S)-2-[[(1r,4S)-4-(aminomethyl)cyclohexane-1-carbonyl]amino]-3-(naphthalen-2-yl)propanoyl]amino]-2-([[(2S)-1,5-di-tert-butoxy-1,5-dioxopentan-2-yl]carbamoyl]amino)hexanoic acid |
| Lutetium (177Lu) vipivotide tetraxetan-012 | 137076-54-1 | DOTA-Tris(t-Bu)ester |
| Lutetium (177Lu) vipivotide tetraxetan-013 | 1702967-37-0 | (3S,10S,14S)-3-[(Naphthalen-2-yl)methyl]-1,4,12-trioxo-1-[(1r,4S)-4-([2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetamido]methyl)cyclohexyl]-2,5,11,13-tetraazahexadecane-10,14,16-tricarboxylic acid |
OptimisedRoute 6Steps 5 · Total yield 176mg(PSMA-617 (Free))
Lutetium (177Lu) vipivotide tetraxetan-024—Lutetium (177Lu) vipivotide tetraxetan-019530-62-1Lutetium (177Lu) vipivotide tetraxetan-025—Lutetium (177Lu) vipivotide tetraxetan-026—Lutetium (177Lu) vipivotide tetraxetan-027—Lutetium (177Lu) vipivotide tetraxetan-028—Lutetium (177Lu) vipivotide tetraxetan-008112883-43-9Lutetium (177Lu) vipivotide tetraxetan-029—Lutetium (177Lu) vipivotide tetraxetan-010—Lutetium (177Lu) vipivotide tetraxetan-030—API · Lutetium (177Lu) vipivotide tetraxetan
| Code | CAS No. | Intermediate |
|---|---|---|
| Lutetium (177Lu) vipivotide tetraxetan-024 | - | tert-Butyl N6-[[(9H-fluoren-9-yl)methoxy]carbonyl]-L-lysinate hydrogen chloride |
| Lutetium (177Lu) vipivotide tetraxetan-019 | 530-62-1 | Staab's reagent |
| Lutetium (177Lu) vipivotide tetraxetan-025 | - | tert-Butyl N6-[[(9H-fluoren-9-yl)methoxy]carbonyl]-N2-(1H-imidazole-1-carbonyl)-L-lysinate |
| Lutetium (177Lu) vipivotide tetraxetan-026 | - | Resin bound Fmoc-Glu(t-Bu) |
| Lutetium (177Lu) vipivotide tetraxetan-027 | - | Resin bound (2S)-2-amino-5-tert-butoxy-5-oxopentanoic acid |
| Lutetium (177Lu) vipivotide tetraxetan-028 | - | Resin bound (9S,13S)-9-(tert-butoxycarbonyl)-13-(3-tert-butoxy-3-oxopropyl)-1-(9H-fluoren-9-yl)-3,11-dioxo-2-oxa-4,10,12-triazatetradecan-14-oic acid |
| Lutetium (177Lu) vipivotide tetraxetan-008 | 112883-43-9 | Fmoc-2-Nal-OH |
| Lutetium (177Lu) vipivotide tetraxetan-029 | - | Resin bound (2S)-2-([[(2S)-6-[[(2S)-2-amino-3-(naphthalen-2-yl)propanoyl]amino]-1-tert-butoxy-1-oxohexan-2-yl]carbamoyl]amino)-5-tert-butoxy-5-oxopentanoic acid |
| Lutetium (177Lu) vipivotide tetraxetan-010 | - | Fmoc-tranexamic acid |
| Lutetium (177Lu) vipivotide tetraxetan-030 | - | Resin bound [(2S,6S,13S)-15-[(1r,4S)-4-(aminomethyl)cyclohexyl]-6-(tert-butoxycarbonyl)-2-(3-tert-butoxy-3-oxopropyl)-13-[(naphthalen-2-yl)methyl]-4,12,15-trioxo-3,5,11,14-tetraazapentadecanan-1-oyl]oxy |
OptimisedRoute 7Steps 1 · Total yield 286mg(Lutetium (177Lu) vipivotide tetraxetan-013)
Lutetium (177Lu) vipivotide tetraxetan-030—Lutetium (177Lu) vipivotide tetraxetan-012137076-54-1Lutetium (177Lu) vipivotide tetraxetan-0131702967-37-0API · Lutetium (177Lu) vipivotide tetraxetan
| Code | CAS No. | Intermediate |
|---|---|---|
| Lutetium (177Lu) vipivotide tetraxetan-030 | - | Resin bound [(2S,6S,13S)-15-[(1r,4S)-4-(aminomethyl)cyclohexyl]-6-(tert-butoxycarbonyl)-2-(3-tert-butoxy-3-oxopropyl)-13-[(naphthalen-2-yl)methyl]-4,12,15-trioxo-3,5,11,14-tetraazapentadecanan-1-oyl]oxy |
| Lutetium (177Lu) vipivotide tetraxetan-012 | 137076-54-1 | DOTA-Tris(t-Bu)ester |
| Lutetium (177Lu) vipivotide tetraxetan-013 | 1702967-37-0 | (3S,10S,14S)-3-[(Naphthalen-2-yl)methyl]-1,4,12-trioxo-1-[(1r,4S)-4-([2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetamido]methyl)cyclohexyl]-2,5,11,13-tetraazahexadecane-10,14,16-tricarboxylic acid |
Frequently asked questions
What are the approved indications of Lutetium (177Lu) vipivotide tetraxetan?
Approved indications include: Hormone-sensitive prostate cancer, Castration-resistant prostate cancer, Prostate cancer.
When does the Lutetium (177Lu) vipivotide tetraxetan patent expire?
No public expiry year is available for Lutetium (177Lu) vipivotide tetraxetan yet; this page updates once verified.
How many synthesis routes are recorded for Lutetium (177Lu) vipivotide tetraxetan?
7 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Lutetium (177Lu) vipivotide tetraxetan intermediates?
All intermediates in Lutetium (177Lu) vipivotide tetraxetan routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Lutetium (177Lu) vipivotide tetraxetan intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-10-22