CAS 112704-79-7

4-bromo-2-fluorobenzoic acid4-Bromo-2-fluorobenzene carboxylic acid

Codes: ENZA-008, (XXXVI)992511-1-e

Application context (from source-drug indications)

Hormone-sensitive prostate cancerEnzalutamideCastration-resistant prostate cancerEnzalutamideProstate cancerEnzalutamideChronic lymphocytic leukaemiaLisaftoclaxAcute promyelocytic leukaemiaLisaftoclaxMyelodysplastic syndromeLisaftoclaxAcute myeloid leukaemiaLisaftoclaxDiffuse large B-cell lymphomaLisaftoclaxSystemic lupus erythematosusLisaftoclax

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Enzalutamide	Tier A — Act now	2027
Lisaftoclax	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

EnzalutamideOptimised routesteps: 4total yield: 213.9 g

4-isothiocyanato-2-(trifluoromethyl)benzonitrile→4-bromo-2-fluorobenzoic acid→4-bromo-2-fluoro-N-methylbenzamide→2-amino-2-methylpropanoic acid→2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoic acid→methyl 2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoate

LisaftoclaxOptimised routesteps: 4total yield: /

4-(4-[[6-(4-Chlorophenyl)spiro[3.5]non-6-en-7-yl]methyl]piperazin-1-yl)-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzoic acid→1-[[6-(4-Chlorophenyl)spiro[3.5]non-6-en-7-yl]methyl]piperazine→1,1-Dimethylpropyl 4-bromo-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoate→2-Methylbutan-2-yl 4-(4-[[6-(4-chlorophenyl)spiro[3.5]non-6-en-7-yl]methyl]piperazin-1-yl)-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzoate→4-Bromo-2-fluorobenzene carboxylic acid→1,1-Dimethylpropyl 4-bromo-2-fluoro-benzoate→1H-Pyrrolo[2,3-b]pyridin-5-ol

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