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CAS 1197-18-8
(1r,4r)-4-(aminomethyl)cyclohexanecarboxylic acid
Codes: Tranexamic acid, BURIX-001
Application context (from source-drug indications)
肠道疾病Tranexamic acid (Leading BioSciences)术后黏连Tranexamic acid (Leading BioSciences)Intestinal obstructionTranexamic acid (Leading BioSciences)胃肠疾病Tranexamic acid (Leading BioSciences)COVID-19Tranexamic acid (Leading BioSciences)感染性休克Tranexamic acid (Leading BioSciences)Haematopoietic stem cell transplantationBurixafor HydrobromideProstate cancerBurixafor HydrobromideAcute myeloid leukaemiaBurixafor HydrobromideMultiple myelomaBurixafor HydrobromideNon-Hodgkin lymphomaBurixafor HydrobromideHodgkin's diseaseBurixafor Hydrobromide
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Tranexamic acid (Leading BioSciences) | Tier C — Watch / trade | - |
| Burixafor Hydrobromide | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
dimethyl terephthalate→potassium 4-(methoxycarbonyl)benzoate→methyl 4-(chlorocarbonyl)benzoate→methyl 4-carbamoylbenzoate→methyl 4-cyanobenzoate→methyl 4-(acetamidomethyl)benzoate→methyl 4-(acetamidomethyl)cyclohexane-1-carboxylate→Tranexamic acid
Tranexamic acid→4-(acetamidomethyl)benzoic acid→sodium 4-(acetamidomethyl)cyclohexane-1-carboxylate→sodium (1r,4r)-4-(aminomethyl)cyclohexane-1-carboxylate→(1r,4r)-4-(aminomethyl)cyclohexane-1-carboxylic acid compound with 4-methylbenzenesulfonic acid (1:1)
N2-(((1r,4r)-4-(aminomethyl)cyclohexyl)methyl)-6-chloropyrimidine-2,4-diamine→(1r,4r)-4-(((tert-butoxycarbonyl)amino)methyl)cyclohexane-1-carboxylic acid→tert-butyl (((1r,4r)-4-carbamoylcyclohexyl)methyl)carbamate→tert-butyl (((1r,4r)-4-cyanocyclohexyl)methyl)carbamate→tert-butyl (((1r,4r)-4-(aminomethyl)cyclohexyl)methyl)carbamate→2,6-dichloropyrimidin-4-amine→tert-butyl (((1r,4r)-4-(((4-amino-6-chloropyrimidin-2-yl)amino)methyl)cyclohexyl)methyl)carbamate→tert-butyl cyclohexyl(3-oxopropyl)carbamate→tert-butyl (3-((((1r,4r)-4-(((4-amino-6-chloropyrimidin-2-yl)amino)methyl)cyclohexyl)methyl)amino)propyl)(cyclohexyl)carbamate→tert-butyl (((1r,4r)-4-(((4-amino-6-chloropyrimidin-2-yl)amino)methyl)cyclohexyl)methyl)(3-((tert-butoxycarbonyl)(cyclohexyl)amino)propyl)carbamate→tert-butyl (((1r,4r)-4-(((4-amino-6-(piperazin-1-yl)pyrimidin-2-yl)amino)methyl)cyclohexyl)methyl)(3-((tert-butoxycarbonyl)(cyclohexyl)amino)propyl)carbamate→diethyl vinylphosphonate→tert-butyl (((1r,4r)-4-(((4-amino-6-(4-(2-(diethoxyphosphoryl)ethyl)piperazin-1-yl)pyrimidin-2-yl)amino)methyl)cyclohexyl)methyl)(3-((tert-butoxycarbonyl)(cyclohexyl)amino)propyl)carbamate→Burixafor Hydrobromide→(1r,4r)-4-(aminomethyl)cyclohexanecarboxylic acid
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