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CAS 1375257-24-1
(4S)-3-Acetyl-1-[(1R)-1-phenylethyl]-4-(propan-2-yl)imidazolidin-2-one(S)-3-acetyl-4-isopropyl-1-((R)-1-phenylethyl)imidazolidin-2-one
Codes: Atorvastatin-112, R-fluoxetine-008
Application context (from source-drug indications)
Cardiac and vascular disordersAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHypertensionAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHyperlipidaemiaAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHeart diseaseAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHyperlipidaemiaAtorvastatin strontiumSubarachnoid haemorrhageAtorvastatin strontiumHypertensionAtorvastatin strontium分离性焦虑R-fluoxetineAnxietyR-fluoxetineAnxiety disorderR-fluoxetine
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Atorvastatin/Hydrochlorothiazide/Aspirin/Enalapril | Tier C — Watch / trade | - |
| Atorvastatin strontium | Tier C — Watch / trade | - |
| R-fluoxetine | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(4S)-1-[(1R)-1-Phenylethyl]-4-(propan-2-yl)imidazolidin-2-one→Acetic acid chloride→(4S)-3-Acetyl-1-[(1R)-1-phenylethyl]-4-(propan-2-yl)imidazolidin-2-one→3-Benzyloxy-1-propanal→(3R)-5-(Benzyloxy)-3-[[tert-butyl(dimethyl)silyl]oxy]pentanoic acid→(4S)-3-[(3R)-5-(Benzyloxy)-3-hydroxypentanoyl]-4-isopropyl-1-[(1R)-1-phenylethyl]imidazolidin-2-one→(3R)-5-(Benzyloxy)-3-hydroxypentanoic acid→Methyl (3R)-5-(benzyloxy)-3-hydroxypentanoate→Methyl (3R)-5-(benzyloxy)-3-[[tert-butyl(dimethyl)silyl]oxy]pentanoate→(4S)-3-[(3R,5R)-7-(Benzyloxy)-5-[[tert-butyl(dimethyl)silyl]oxy]-3-hydroxyheptanoyl]-4-isopropyl-1-[(1R)-1-phenylethyl]imidazolidin-2-one→(3R,5R)-7-(Benzyloxy)-5-[[tert-butyl(dimethyl)silyl]oxy]-3-hydroxyheptanoic acid→Methyl (3R,5R)-7-(benzyloxy)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]heptanoate→Methyl (3R,5R)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]-7-hydroxyheptanoate→Methyl (3R,5R)-7-azido-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]heptanoate
(4S)-1-[(1R)-1-Phenylethyl]-4-(propan-2-yl)imidazolidin-2-one→Acetic acid chloride→(4S)-3-Acetyl-1-[(1R)-1-phenylethyl]-4-(propan-2-yl)imidazolidin-2-one→3-Benzyloxy-1-propanal→(3R)-5-(Benzyloxy)-3-[[tert-butyl(dimethyl)silyl]oxy]pentanoic acid→(4S)-3-[(3R)-5-(Benzyloxy)-3-hydroxypentanoyl]-4-isopropyl-1-[(1R)-1-phenylethyl]imidazolidin-2-one→(3R)-5-(Benzyloxy)-3-hydroxypentanoic acid→Methyl (3R)-5-(benzyloxy)-3-hydroxypentanoate→Methyl (3R)-5-(benzyloxy)-3-[[tert-butyl(dimethyl)silyl]oxy]pentanoate→(4S)-3-[(3R,5R)-7-(Benzyloxy)-5-[[tert-butyl(dimethyl)silyl]oxy]-3-hydroxyheptanoyl]-4-isopropyl-1-[(1R)-1-phenylethyl]imidazolidin-2-one→(3R,5R)-7-(Benzyloxy)-5-[[tert-butyl(dimethyl)silyl]oxy]-3-hydroxyheptanoic acid→Methyl (3R,5R)-7-(benzyloxy)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]heptanoate→Methyl (3R,5R)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]-7-hydroxyheptanoate→Methyl (3R,5R)-7-azido-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]heptanoate
(S)-2-amino-3-methylbutanoic acid→(tert-butoxycarbonyl)-L-valine→(R)-1-phenylethan-1-amine→tert-butyl ((S)-3-methyl-1-oxo-1-(((R)-1-phenylethyl)amino)butan-2-yl)carbamate→(S)-2-amino-3-methyl-N-((R)-1-phenylethyl)butanamide→(S)-3-methyl-N1-((R)-1-phenylethyl)butane-1,2-diamine→(S)-4-isopropyl-1-((R)-1-phenylethyl)imidazolidin-2-one→(S)-3-acetyl-4-isopropyl-1-((R)-1-phenylethyl)imidazolidin-2-one→(S)-3-((R)-3-hydroxy-3-phenylpropanoyl)-4-isopropyl-1-((R)-1-phenylethyl)imidazolidin-2-one→(R)-3-hydroxy-N-methyl-3-phenylpropanamide→(R)-3-(methylamino)-1-phenylpropan-1-ol→1-fluoro-4-(trifluoromethyl)benzene→R-fluoxetine
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