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CAS 2987-16-8
3,3-Dimethylbutanal3,3-dimethylbutanal
Codes: (Ib)409139-5-a, IDAS-015
Application context (from source-drug indications)
Transthyretin amyloidosisTafamidisHeart diseaseTafamidisSolid tumourIdasanutlinAcute myeloid leukaemiaIdasanutlinPolycythaemia veraIdasanutlinLeukaemiaIdasanutlinAcute lymphoblastic leukaemiaIdasanutlinNeuroblastomaIdasanutlin
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Tafamidis | Tier C — Watch / trade | - |
| Idasanutlin | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3-Methylbutanal→3,3-Dimethylbutanal→2-(Hydroxymethyl)-2-(propan-2-yl)propane-1,3-diol→2-tert-Butyl-2-(hydroxymethyl)propane-1,3-diol→3,5-Dichlorobenzoic acid→1-(3,5-Dichlorophenyl)-4-(propan-2-yl)-2,6,7-trioxabicyclo[2.2.2]octane→4-tert-Butyl-1-(3,5-dichlorophenyl)-2,6,7-trioxabicyclo[2.2.2]octane→(4-Carboxy-2-hydroxyphenyl)amine→2-(3,5-Dichlorophenyl)benzo[d]oxazole-6-carboxylic acid
(Z)-2-(4-chloro-2-fluoro-6-methylphenyl)-3-(3-chloro-2-fluorophenyl)acrylonitrile→4-amino-3-methoxybenzoic acid→ethyl 4-amino-3-methoxybenzoate→2-chloroacetyl chloride→ethyl 4-(2-aminoacetamido)-3-methoxybenzoate hydrochloride→ethyl 4-(2-aminoacetamido)-3-methoxybenzoate hydrochloride→3,3-dimethylbutanal→ethyl (E)-4-(2-((3,3-dimethylbutylidene)amino)acetamido)-3-methoxybenzoate→ethyl 4-((2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamido)-3-methoxybenzoate
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