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CAS 39684-80-5
2-(Boc-Amino)ethyl bromidetert-butyl (2-bromoethyl)carbamate
Codes: Tamsulosin Hydrochloride-113, Tani-010
Application context (from source-drug indications)
Erectile dysfunctionTadalafil/TamsulosinBenign prostatic hyperplasiaTadalafil/TamsulosinLower urinary tract symptomsSolifenacin Succinate/Tamsulosin HydrochlorideBenign prostatic hyperplasiaSolifenacin Succinate/Tamsulosin HydrochlorideOveractive bladderSolifenacin Succinate/Tamsulosin HydrochlorideDrug-related adverse effects and reactionsSolifenacin Succinate/Tamsulosin HydrochlorideBladder neck obstructionSolifenacin Succinate/Tamsulosin HydrochlorideBenign prostatic hyperplasiaDutasteride/Tamsulosin HydrochlorideBenign prostatic hyperplasiaTamsulosin HydrochlorideUrinary tract infectionTamsulosin HydrochlorideUrinary retentionTamsulosin HydrochlorideInguinal herniaTamsulosin HydrochlorideVoiding dysfunctionTamsulosin HydrochlorideLower urinary tract symptomsTamsulosin HydrochlorideUrinary tract infectionTaniborbactamPyelonephritisTaniborbactam
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Tadalafil/Tamsulosin | Tier C — Watch / trade | - |
| Solifenacin Succinate/Tamsulosin Hydrochloride | Tier C — Watch / trade | - |
| Dutasteride/Tamsulosin Hydrochloride | Tier C — Watch / trade | - |
| Tamsulosin Hydrochloride | Tier C — Watch / trade | - |
| Taniborbactam | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-(Boc-Amino)ethyl bromide→tert-Butyl (2-chloroethyl)carbamate→1-Hydroxy-2-ethoxybenzene→N-Boc-2-(2-ethoxyphenoxy)ethanamine→2-(2-Ethoxyphenoxy)ethylamine→(2S)-1-(4-Methoxy-3-sulfamoylphenyl)propan-2-yl methanesulfonate→(2S)-1-(4-Methoxy-3-sulfamoylphenyl)propan-2-yl trifluoroacetate→5-[(2S)-2-Hydroxypropyl]-2-methoxybenzene-1-sulfonamide
Solifenacin Succinate/Tamsulosin HydrochlorideProcess routesteps: 4total yield: 25.51kg(Tamsulosin Hydrochloride (API))
2-(Boc-Amino)ethyl bromide→tert-Butyl (2-chloroethyl)carbamate→1-Hydroxy-2-ethoxybenzene→N-Boc-2-(2-ethoxyphenoxy)ethanamine→2-(2-Ethoxyphenoxy)ethylamine→(2S)-1-(4-Methoxy-3-sulfamoylphenyl)propan-2-yl methanesulfonate→(2S)-1-(4-Methoxy-3-sulfamoylphenyl)propan-2-yl trifluoroacetate→5-[(2S)-2-Hydroxypropyl]-2-methoxybenzene-1-sulfonamide
Dutasteride/Tamsulosin HydrochlorideProcess routesteps: 4total yield: 25.51kg(Tamsulosin Hydrochloride (API))
2-(Boc-Amino)ethyl bromide→tert-Butyl (2-chloroethyl)carbamate→1-Hydroxy-2-ethoxybenzene→N-Boc-2-(2-ethoxyphenoxy)ethanamine→2-(2-Ethoxyphenoxy)ethylamine→(2S)-1-(4-Methoxy-3-sulfamoylphenyl)propan-2-yl methanesulfonate→(2S)-1-(4-Methoxy-3-sulfamoylphenyl)propan-2-yl trifluoroacetate→5-[(2S)-2-Hydroxypropyl]-2-methoxybenzene-1-sulfonamide
2-(Boc-Amino)ethyl bromide→tert-Butyl (2-chloroethyl)carbamate→1-Hydroxy-2-ethoxybenzene→N-Boc-2-(2-ethoxyphenoxy)ethanamine→2-(2-Ethoxyphenoxy)ethylamine→(2S)-1-(4-Methoxy-3-sulfamoylphenyl)propan-2-yl methanesulfonate→(2S)-1-(4-Methoxy-3-sulfamoylphenyl)propan-2-yl trifluoroacetate→5-[(2S)-2-Hydroxypropyl]-2-methoxybenzene-1-sulfonamide
2-methoxy-3-methylbenzoic acid→tert-butyl 2-methoxy-3-methylbenzoate→tert-butyl 3-(bromomethyl)-2-methoxybenzoate→Benzoic acid, 3-[[(3aR,4R,6R,7aS)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]methyl]-2-methoxy-, 1,1-dimethylethyl ester→Benzoic acid, 3-[(2S )-2-chloro-2-[(3aR ,4R ,6R ,7aS )-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]ethyl]-2-
methoxy-, 1,1-dimethylethyl ester→Benzoic acid, 3-[(2R )-2-amino-2-[(3aR ,4R ,6R ,7aS )-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]ethyl]-2-
methoxy-, 1,1-dimethylethyl ester→2-((1r,4r)-4-(tert-butoxycarbonyl(2-(tert-butoxycarbonylamino)ethyl)amino)cyclohexyl)acetic acid→tert-butyl 3-((R)-2-(2-((1r,4R)-4-((tert-butoxycarbonyl)(2-((tert-butoxycarbonyl)amino)ethyl)amino)cyclohexyl)acetamido)-2-((3aR,4R,6R,7aS)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)ethyl)-2-methoxybenzoate→ethyl 2-((1r,4r)-4-aminocyclohexyl)acetate→tert-butyl (2-bromoethyl)carbamate→ethyl 2-((1r,4r)-4-(2-(tert-butoxycarbonylamino)ethylamino)cyclohexyl)acetate→ethyl 2-((1r,4r)-4-(tert-butoxycarbonyl(2-(tert-butoxycarbonylamino)ethyl)amino)cyclohexyl)acetate
Intermediates available on this site
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This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.