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CAS 5794-88-7
2-amino-5-bromobenzoic acid
Codes: REMIB-001, DACT-010
Application context (from source-drug indications)
SedationRemimazolam BesilateAnaesthesiaRemimazolam BesilateCOVID-19DactolisibRespiratory tract infectionDactolisibBreast cancerDactolisib呼吸障碍DactolisibSolid tumourDactolisibPancreatic neuroendocrine tumourDactolisib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Remimazolam Besilate | Tier C — Watch / trade | 2030 |
| Dactolisib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-amino-5-bromobenzoic acid→2-bromopyridine→(2-amino-5-bromophenyl)(pyridin-2-yl)methanone→(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-methoxy-5-oxopentanoic acid→methyl (S)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-((4-bromo-2-picolinoylphenyl)amino)-5-oxopentanoate→methyl (S)-3-(7-bromo-2-oxo-5-(pyridin-2-yl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanoate→dimorpholinophosphinic chloride→methyl (S)-3-(7-bromo-2-((dimorpholinophosphoryl)oxy)-5-(pyridin-2-yl)-3H-benzo[e][1,4]diazepin-3-yl)propanoate→1-aminopropan-2-ol→methyl 3-((3S)-7-bromo-2-((2-hydroxypropyl)amino)-5-(pyridin-2-yl)-3H-benzo[e][1,4]diazepin-3-yl)propanoate
2-(4-nitrophenyl)acetonitrile→2-methyl-2-(4-nitrophenyl)propanenitrile→2-(4-aminophenyl)-2-methylpropanenitrile→6-bromo-4-chloro-3-nitroquinoline→2-(4-((6-bromo-3-nitroquinolin-4-yl)amino)phenyl)-2-methylpropanenitrile→2-(4-((3-amino-6-bromoquinolin-4-yl)amino)phenyl)-2-methylpropanenitrile→2-(4-(8-bromo-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile→2-(4-(8-bromo-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile→quinolin-3-ylboronic acid→2-amino-5-bromobenzoic acid→(E)-5-bromo-2-((2-nitrovinyl)amino)benzoic acid→6-bromo-3-nitroquinolin-4-ol
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