← Back to patent-cliff list
CAS 616-30-8
3-aminopropane-1,2-diol
Codes: DOLU-029, PXS-4728-001
Application context (from source-drug indications)
HIV infectionDolutegravir SodiumLabour and deliveryDolutegravir SodiumMycobacterium tuberculosis infectionDolutegravir SodiumHepatitisDolutegravir SodiumHerpesvirus infectionDolutegravir SodiumHepatic function declineDolutegravir SodiumREM睡眠行为障碍PXS-4728Diabetic retinopathyPXS-4728Non-alcoholic steatohepatitisPXS-4728Renal impairmentPXS-4728
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Dolutegravir Sodium | Tier B — Position early | - |
| PXS-4728 | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3-hydroxy-2-methyl-4H-pyran-4-one→3-(benzyloxy)-2-methyl-4H-pyran-4-one→(2,4-difluorophenyl)methanamine→(R)-3-aminobutan-1-ol→(4R,12aS)-7-(benzyloxy)-N-(2,4-difluorobenzyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide→3-(benzyloxy)-2-(2-hydroxy-2-phenylethyl)-4H-pyran-4-one→(E)-3-(benzyloxy)-2-styryl-4H-pyran-4-one→3-(benzyloxy)-4-oxo-4H-pyran-2-carboxylic acid→3-aminopropane-1,2-diol→3-(benzyloxy)-1-(2,3-dihydroxypropyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid→methyl 3-(benzyloxy)-1-(2,3-dihydroxypropyl)-4-oxo-1,4-dihydropyridine-2-carboxylate→methyl 3-(benzyloxy)-1-(2,2-dihydroxyethyl)-4-oxo-1,4-dihydropyridine-2-carboxylate→(4R,12aS)-7-(benzyloxy)-4-methyl-3,4,12,12a-tetrahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-6,8-dione→(4R,12aS)-7-(benzyloxy)-9-bromo-4-methyl-3,4,12,12a-tetrahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-6,8-dione
PXS-4728→3-aminopropane-1,2-diol→tert-butyl (3-((tert-butyldimethylsilyl)oxy)-2-hydroxypropyl)carbamate→tert-butyl (3-((tert-butyldimethylsilyl)oxy)-2-oxopropyl)carbamate→tert-butyl (2-(((tert-butyldimethylsilyl)oxy)methyl)-3-fluoroallyl)carbamate→(E)-tert-butyl (3-fluoro-2-(hydroxymethyl)allyl)carbamate→(E)-tert-butyl (2-(bromomethyl)-3-fluoroallyl)carbamate→N-(tert-butyl)-4-hydroxybenzamide→(E)-tert-butyl (2-((4-(tert-butylcarbamoyl)phenoxy)methyl)-3-fluoroallyl)carbamate
Intermediates available on this site
No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.