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CAS 62-56-6
thioureaThiocarbamideSulfoureaAminothiocarboxamide
Codes: TICA-041, AVAN-026, AVAT-003, LUSU-007, Tenofovir disoproxil phosphate-044, Ceftazidime-005, Ceftazidime-047, PIOG-007, FEBU-014, Cefoselis Sulfate-033, S-pantoprazole sodium-055, Cefcamate Pivoxil Hydrochloride-028
Application context (from source-drug indications)
StrokeTicagrelorAcute coronary syndromeTicagrelorMyocardial infarctionTicagrelorPeripheral vascular diseaseTicagrelorErectile dysfunctionAvanafilThrombocytopeniaAvatrombopag MaleateImmune thrombocytopenic purpuraAvatrombopag MaleateLiver diseaseAvatrombopag MaleateThrombocytopeniaLusutrombopagHIV infectionLamivudine/Tenofovir Disoproxil FumarateChronic hepatitis BLamivudine/Tenofovir Disoproxil FumarateHIV infectionEfavirenz/Lamivudine/Tenofovir Disoproxil FumarateCystitisAvibactam Sodium/CeftazidimeCholecystitisAvibactam Sodium/CeftazidimePeritonitisAvibactam Sodium/CeftazidimeIntra-abdominal infectionAvibactam Sodium/CeftazidimeLiver abscessAvibactam Sodium/CeftazidimeSepsisAvibactam Sodium/CeftazidimeHIV infectionEmtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil FumarateType 2 diabetesAlogliptin Benzoate/Pioglitazone HydrochlorideBacterial infectionCeftazidime/Tazobactam SodiumRespiratory tract infectionCeftazidime/Tazobactam SodiumUrinary tract infectionCeftazidime/Tazobactam SodiumHyperuricaemiaFebuxostatGoutFebuxostatIntracranial haemorrhageFebuxostatUlcerative colitisFebuxostatChronic renal impairmentFebuxostatPainFebuxostatBacterial infectionCefoselis SulfateGastro-oesophageal reflux diseaseS-pantoprazole sodiumPeptic ulcerS-pantoprazole sodiumHaemorrhageS-pantoprazole sodiumTrauma and injuryS-pantoprazole sodiumComaS-pantoprazole sodiumAspiration pneumoniaS-pantoprazole sodiumHepatitis BTenofovir disoproxil phosphateBacterial infectionCeftazidimeGram-positive bacterial infectionCeftazidimeGram-negative bacterial infectionCeftazidimeGynaecological disorderCeftazidimeIntra-abdominal infectionCeftazidimeOsteoarthritisCeftazidimeType 2 diabetesPioglitazone HydrochloridePulmonary hypertensionPioglitazone HydrochlorideBreast cancerPioglitazone HydrochlorideNon-alcoholic steatohepatitisPioglitazone HydrochlorideCocaine addictionPioglitazone HydrochlorideAlcohol abusePioglitazone HydrochlorideBacterial infectionCefcamate Pivoxil Hydrochloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Ticagrelor | Tier B — Position early | 2029 |
| Avanafil | Tier C — Watch / trade | 2028 |
| Avatrombopag Maleate | Tier C — Watch / trade | 2030 |
| Lusutrombopag | Tier C — Watch / trade | 2031 |
| Lamivudine/Tenofovir Disoproxil Fumarate | Tier C — Watch / trade | - |
| Efavirenz/Lamivudine/Tenofovir Disoproxil Fumarate | Tier C — Watch / trade | - |
| Avibactam Sodium/Ceftazidime | Tier C — Watch / trade | - |
| Emtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil Fumarate | Tier B — Position early | - |
| Alogliptin Benzoate/Pioglitazone Hydrochloride | Tier C — Watch / trade | - |
| Ceftazidime/Tazobactam Sodium | Tier C — Watch / trade | - |
| Febuxostat | Tier C — Watch / trade | - |
| Cefoselis Sulfate | Tier C — Watch / trade | - |
| S-pantoprazole sodium | Tier C — Watch / trade | - |
| Tenofovir disoproxil phosphate | Tier C — Watch / trade | - |
| Ceftazidime | Tier C — Watch / trade | - |
| Pioglitazone Hydrochloride | Tier B — Position early | - |
| Cefcamate Pivoxil Hydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4,6-dichloro-2-(propylthio)pyrimidin-5-amine→diethyl 2-acetamidomalonate→thiourea→sodium 5-acetamido-4,6-dihydroxypyrimidine-2-thiolate→N-(4,6-dihydroxy-2-mercaptopyrimidin-5-yl)acetamide→1-bromopropane→N-(4,6-dihydroxy-2-(propylthio)pyrimidin-5-yl)acetamide→5-amino-2-(propylthio)pyrimidine-4,6-diol hydrochloride
diethyl 2-(ethoxymethylene)malonate→(3-chloro-4-methoxyphenyl)methanamine hydrochloride→(S)-pyrrolidin-2-ylmethanol→pyrimidin-2-ylmethanamine→thiourea→AVAN-027→AVAN-028→AVAN-029→AVAN-030→AVAN-031→AVAN-032→AVAN-033
1-(4-chlorothiophen-2-yl)ethanone→2-bromo-1-(4-chlorothiophen-2-yl)ethanone→thiourea→4-(4-chlorothiophen-2-yl)thiazol-2-amine→1-cyclohexylpiperazine→4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine→5,6-dichloronicotinic acid→5,6-dichloro-N-(4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)nicotinamide→ethyl piperidine-4-carboxylate→ethyl 1-(3-chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylate→maleic acid
1-(3-bromo-2-methoxyphenyl)ethanone→(S)-1-(3-bromo-2-methoxyphenyl)ethanol→1-iodohexane→(S)-1-bromo-3-(1-(hexyloxy)ethyl)-2-methoxybenzene→2-chloro-N-methoxy-N-methylacetamide→(S)-2-chloro-1-(3-(1-(hexyloxy)ethyl)-2-methoxyphenyl)ethanone→thiourea→(S)-4-(3-(1-(hexyloxy)ethyl)-2-methoxyphenyl)thiazol-2-amine→(E)-3,5-dichloro-4-(3-ethoxy-2-methyl-3-oxoprop-1-en-1-yl)benzoic acid→(S,E)-ethyl 3-(2,6-dichloro-4-((4-(3-(1-(hexyloxy)ethyl)-2-methoxyphenyl)thiazol-2-yl)carbamoyl)phenyl)-2-methylacrylate→3,5-dichloro-4-formylbenzoic acid→ethyl 2-(diethoxyphosphoryl)propanoate
(R)-1-(6-Amino-9H-purin-9-yl)propan-2-ol→(Diethoxyphosphoryl)methyl 4-methylbenzene-1-sulfonate→(R)-9-[2-(Diethylphosphonomethoxy)propyl] adenine→Carbamide→Thiocarbamide→Guanidine→Ethoxy(imino)methanaminium ethyl ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate→(Ethylsulfanyl)(imino)methanaminium ethyl ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate→(Ethylamino)(imino)methanaminium ethyl ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | 4-(4-chloro-2-thienyl)-2-ThiazolaMine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 1-Cyclohexylpiperazine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 5,6-Dichloronicotinic acid Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 4,6-Dichloro-2-(propylthio)pyrimidin -5-amine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 2-((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro -3aH-cyclopenta[d][1,3]dioxol -4-yloxy)ethanol L-tataric acid Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanaminium(2R)hydroxy(phenyl)ethanoate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | Ethanol, 2-[[(3aR,4S,6R,6aS)-6-[[5-aMino-6-chloro-2-(propylthio)-4-pyriMidinyl]aMino]tetrahydro-2,2-diMethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]- Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | Cyclopropanamine,2-(3,4-difluorophenyl)-(1R,2S) -(2R,3R)-2,3-dihydroxybutanedioate (1:1) Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 2-[[(3aS,4R,6S,6aR)-4-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-6-yl]oxy]ethanol Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.