CAS 771-99-3

4-Phenylpiperidine4-phenylpiperidine

Codes: (XX)859946-1-b, (V)663167-2-a, ADX-71149-006

Application context (from source-drug indications)

Biliary tract cancerTasurgratinibBile duct cancerTasurgratinibSolid tumourTasurgratinibCholangiocarcinomaTasurgratinibBreast cancerTasurgratinibHepatic function declineTasurgratinibSeizureADX-71149Major depressive disorderADX-71149SchizophreniaADX-71149意识错乱ADX-71149知觉障碍ADX-71149

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Tasurgratinib	Tier C — Watch / trade	-
ADX-71149	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

TasurgratinibOptimised routesteps: 4total yield: /

4-[1-(tert-Butoxycarbonyl)piperidin-4-yl]benzoic acid→4-Phenylpiperidine→1-(4-Phenylpiperidin-1-yl)ethan-1-one→4-(1-Acetylpiperidin-4-yl)benzoic acid→4-(Piperidin-4-yl)benzoic acid hydrogen chloride→N-Boc-4-(4-bromophenyl)piperidine

TasurgratinibOptimised routesteps: 3total yield: /

1-(Phenylmethyl)-4-piperidinone→Bromo(phenyl)magnesium→1-Benzyl-4-phenylpiperidin-4-ol→1-Benzyl-4-phenyl-1,2,3,6-tetrahydropyridine→4-Phenylpiperidine

ADX-71149Originator routesteps: 5total yield: 0.39 g

1-butyl-3-chloro-4-(4-phenylpiperidin-1-yl)pyridin-2(1H)-one→4-(benzyloxy)pyridin-2(1H)-one→1-bromobutane→4-(benzyloxy)-1-butylpyridin-2(1H)-one→1-butyl-4-hydroxypyridin-2(1H)-one→4-bromo-1-butylpyridin-2(1H)-one→4-phenylpiperidine→1-butyl-4-(4-phenylpiperidin-1-yl)pyridin-2(1H)-one

Intermediates available on this site

No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.