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CAS 777-52-6
4-nitrophenyl phosphorodichloridate
Codes: SOFO-016, MB07133-005
Application context (from source-drug indications)
Hepatitis CSofosbuvir/VelpatasvirChronic hepatitis CSofosbuvir/VelpatasvirEnd-stage renal diseaseSofosbuvir/VelpatasvirLiver transplant rejectionSofosbuvir/VelpatasvirKidney transplant rejectionSofosbuvir/VelpatasvirHeart failureSofosbuvir/VelpatasvirChronic hepatitis CSofosbuvirHepatitis CSofosbuvirChronic hepatitis BSofosbuvirHepatitis E virus infectionSofosbuvirLiver cirrhosisSofosbuvirPortal hypertensionSofosbuvirLiver cancerPracytarabineHepatocellular carcinomaPracytarabine线粒体疾病PracytarabineCholangiocarcinomaPracytarabine
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Sofosbuvir/Velpatasvir | Tier B — Position early | - |
| Sofosbuvir | Tier B — Position early | - |
| Pracytarabine | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione→(S)-isopropyl 2-aminopropanoate hydrochloride→1-((2R,3R,4R,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3-fluoro-4-hydroxy-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione→4-oxopentanoic anhydride→(2R,3R,4R,5R)-2-(((tert-butyldimethylsilyl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-4-methyltetrahydrofuran-3-yl 4-oxopentanoate→(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-yl 4-oxopentanoate→(S)-isopropyl 2-(((R)-(4-nitrophenoxy)(phenoxy)phosphoryl)amino)propanoate→(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-((((S)-(((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)-4-methyltetrahydrofuran-3-yl 4-oxopentanoate→phenol→4-nitrophenyl phosphorodichloridate
1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione→(S)-isopropyl 2-aminopropanoate hydrochloride→1-((2R,3R,4R,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3-fluoro-4-hydroxy-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione→4-oxopentanoic anhydride→(2R,3R,4R,5R)-2-(((tert-butyldimethylsilyl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-4-methyltetrahydrofuran-3-yl 4-oxopentanoate→(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-yl 4-oxopentanoate→(S)-isopropyl 2-(((R)-(4-nitrophenoxy)(phenoxy)phosphoryl)amino)propanoate→(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-((((S)-(((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)-4-methyltetrahydrofuran-3-yl 4-oxopentanoate→phenol→4-nitrophenyl phosphorodichloridate
(E)-N'-(1-((2R,3S,4R,5R)-3,4-bis((tert-butyldimethylsilyl)oxy)-5-((((2R,4S)-2-oxido-4-(pyridin-4-yl)-1,3,2-dioxaphosphinan-2-yl)oxy)methyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-N,N-dimethylformimidamide→ethyl 3-hydroxy-3-(pyridin-4-yl)propanoate→N,N-dimethyl-L-phenylalanine→(S)-3-ethoxy-3-oxo-1-(pyridin-4-yl)propyl dimethyl-L-phenylalaninate→(S)-1-(pyridin-4-yl)propane-1,3-diol→4-nitrophenyl phosphorodichloridate→(2S,4S)-2-(4-nitrophenoxy)-4-(pyridin-4-yl)-1,3,2-dioxaphosphinane 2-oxide→(E)-N'-(1-((2R,3S,4R,5R)-3,4-bis((tert-butyldimethylsilyl)oxy)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-N,N-dimethylformimidamide
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Taizhou GMP-like Site | 2'-Deoxy-2'-fluoro-2'- Methyl-N-(phenylcarbonyl) cytidine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 2'-deoxy-2'-fluoro-2'-C-methyluridine Pharmaceutical Intermediates | On request | On request | On request | — |
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