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CAS 86483-52-5
cyclopropanamine
Codes: LENT-013, TRAT-002, FINA-009, TELAP-021, ABAC-008
Application context (from source-drug indications)
Renal cell carcinomaLenvatinib MesilateEndometrial cancerLenvatinib MesilateHepatocellular carcinomaLenvatinib MesilateThyroid cancerLenvatinib MesilateThyroid cancerTrametinibGliomaTrametinibHairy cell leukaemiaTrametinibAnaplastic thyroid cancerTrametinibSolid tumourTrametinibNon-small cell lung cancerTrametinibOtitis externaFinafloxacinOtitis media with effusionFinafloxacinOtitis mediaFinafloxacinUrinary tract infectionFinafloxacinPyelonephritisFinafloxacinGram-negative bacterial infectionFinafloxacinHepatitis CTelaprevirChronic hepatitis CTelaprevirHIV infectionTelaprevirHepatic function declineTelaprevirOpioid dependenceTelaprevirKidney diseaseTelaprevirHIV infectionAbacavir Sulfate艾滋病痴呆综合征Abacavir Sulfate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Lenvatinib Mesilate | Tier A — Act now | 2028 |
| Trametinib | Tier C — Watch / trade | 2029 |
| Finafloxacin | Tier C — Watch / trade | - |
| Telaprevir | Tier B — Position early | - |
| Abacavir Sulfate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-amino-2-chlorobenzonitrile→4-amino-2-methoxybenzonitrile→5-(ethoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione→4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzonitrile→7-methoxy-4-oxo-1,4-dihydroquinoline-6-carbonitrile→7-methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylic acid→4-chloro-7-methoxyquinoline-6-carbonyl chloride→4-chloro-7-methoxyquinoline-6-carboxamide→4-amino-3-chlorophenol→4-(4-amino-3-chlorophenoxy)-7-methoxyquinoline-6-carboxamide→phenyl carbonochloridate→phenyl (4-((6-carbamoyl-7-methoxyquinolin-4-yl)oxy)-2-chlorophenyl)carbamate→cyclopropanamine
2-fluoro-4-iodoaniline→cyclopropanamine→1-cyclopropyl-3-(2-fluoro-4-iodophenyl)urea→2-cyanoacetic acid→2-cyano-N-cyclopropyl-N-((2-fluoro-4-iodophenyl)carbamoyl)acetamide→6-amino-3-cyclopropyl-1-(2-fluoro-4-iodophenyl)pyrimidine-2,4(1H,3H)-dione→(E)-N'-(1-cyclopropyl-3-(2-fluoro-4-iodophenyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-N,N-dimethylformimidamide→3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione→2-methylmalonic acid→3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethylpyrido[2,3-d]pyrimidine-2,4,7(1H,3H,8H)-trione→3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl 4-methylbenzenesulfonate→N-(3-aminophenyl)acetamide→N-(3-((3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl)amino)phenyl)acetamide
1-fluoro-3,5-dimethylbenzene→2,4-dichloro-1-fluoro-3,5-dimethylbenzene→2,4-dichloro-3-(dichloromethyl)-1-fluoro-5-(trichloromethyl)benzene→2,4-dichloro-5-fluoro-3-formylbenzoic acid→(Z)-2,4-dichloro-5-fluoro-3-((hydroxyimino)methyl)benzoic acid→2,4-dichloro-3-cyano-5-fluorobenzoyl chloride→(Z)-ethyl 3-(dimethylamino)acrylate→ethyl 2-(2,4-dichloro-3-cyano-5-fluorobenzoyl)-3-(dimethylamino)acrylate→cyclopropanamine→ethyl 3-(cyclopropylamino)-2-(2,4-dichloro-3-cyano-5-fluorobenzoyl)acrylate→ethyl 7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate→7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid→(4aS,7aS)-octahydropyrrolo[3,4-b][1,4]oxazine→(E)-but-2-ene-1,4-diol→1-tosyl-2,5-dihydro-1H-pyrrole→3-tosyl-6-oxa-3-azabicyclo[3.1.0]hexane→2-aminoethan-1-ol→4-((2-hydroxyethyl)amino)-1-tosylpyrrolidin-3-ol→2-(N-(4-hydroxy-1-tosylpyrrolidin-3-yl)-4-methylphenylsulfonamido)ethyl 4-methylbenzenesulfonate→4,6-ditosyloctahydropyrrolo[3,4-b][1,4]oxazine→(4aS,7aS)-4,6-ditosyloctahydropyrrolo[3,4-b][1,4]oxazine
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Taizhou GMP-like Site | 4-Chloro-7-methoxyquinoline -6-carboxylic acid methyl ester Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 4-Chloro-7-methoxyquinoline -6-carboxamide Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | N-(2-Chloro-4-hydroxyphenyl)-N'-cyclopropyl-urea Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 4-Amino-3-chlorophenol Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.