CAS 87-62-7

2-Amino-1,3-dimethylbenzene2,6-dimethylaniline

Codes: (III)91311-1-a, (IV)91311-2-a, (I)91311-3-a, RANO-002, Vazegepant-009

Application context (from source-drug indications)

PainBupivacaine Hydrochloride/Fentanyl CitrateAngina pectorisRanolazineMyocardial infarctionRanolazineAmyotrophic lateral sclerosisRanolazineStable anginaRanolazineCrohn's diseaseRanolazineInflammatory bowel diseaseRanolazineSubacromial impingement syndromeBupivacainePostoperative painBupivacaineStomatitisBupivacaineHead and neck cancerBupivacaineHypotensionBupivacaineMitral regurgitationBupivacaineMigraineZavegepantMigraine without auraZavegepant有先兆的偏头痛ZavegepantCluster headacheZavegepantAsthmaZavegepantCOVID-19Zavegepant

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Bupivacaine Hydrochloride/Fentanyl Citrate	Tier C — Watch / trade	-
Ranolazine	Tier C — Watch / trade	-
Bupivacaine	Tier C — Watch / trade	-
Zavegepant	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Bupivacaine Hydrochloride/Fentanyl CitrateOptimised routesteps: 3total yield: /

(+/-)-Piperidine-2-carboxylic acid→1-[(Benzyloxy)carbonyl]piperidine-2-carboxylic acid→2-Amino-1,3-dimethylbenzene→Phenyl 2-[(2,6-dimethylphenyl)carbamoyl]piperidine-1-carboxylate→(RS)-N-(2,6-Dimethylphenyl)piperidine-2-carboxamide→1-Bromobutane

Bupivacaine Hydrochloride/Fentanyl CitrateOptimised routesteps: 4total yield: /

(+/-)-Piperidine-2-carboxylic acid→DL-Pipecolic acid hydrochloride→Piperidine-2-carbonyl chloride hydrogen chloride→2-Amino-1,3-dimethylbenzene→(RS)-N-(2,6-Dimethylphenyl)piperidine-2-carboxamide→1-Bromobutane

Bupivacaine Hydrochloride/Fentanyl CitrateOptimised routesteps: 1total yield: /

2-Amino-1,3-dimethylbenzene→1-Butylpiperidine-2-carbaldehyde→1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide

RanolazineProcess routesteps: 3total yield: 5.9 kg

2-chloroacetyl chloride→2,6-dimethylaniline→2-chloro-N-(2,6-dimethylphenyl)acetamide→piperazine→N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide→2-((2-methoxyphenoxy)methyl)oxirane

RanolazineOptimised routesteps: 6total yield: 4.35 g

2-chloroacetyl chloride→2,6-dimethylaniline→2-chloro-N-(2,6-dimethylphenyl)acetamide→2-((2-methoxyphenoxy)methyl)oxirane→2-methoxyphenol→2-(chloromethyl)oxirane→2,2'-azanediylbis(ethan-1-ol)→2-(bis(2-hydroxyethyl)amino)-N-(2,6-dimethylphenyl)acetamide→2-(bis(2-chloroethyl)amino)-N-(2,6-dimethylphenyl)acetamide→1-amino-3-(2-methoxyphenoxy)propan-2-ol

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications
Qualified Partner — East China API Works	(R)-METHYL 2-(((BENZYLOXY)CARBONYL)AMINO)-3-(7-METHYL-1H-INDAZOL-5-YL)PROPANOATE Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	3-(piperidin-4-yl)quinolin-2(1h)-one hydrochloride Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	3-(piperidin-4-yl)quinolin-2(1h)-one Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	1-(1-Methyl-4-piperidinyl)piperazine Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	methyl (2R)-2-amino-3-(7-methyl-1H-indazol-5-yl)propanoate dihydrochloride Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	1H-Indazole-5-propanoic acid,α-amino-7-methyl-,methyl ester, (αR)- Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	1-(1-METHYLPIPERIDIN-4-YL)PIPERAZINE 3HCL Pharmaceutical Intermediates	On request	On request	On request	—

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.