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CAS 90719-32-7
(S)-4-benzyloxazolidin-2-one(S)-4-Phenylmethyl-2-oxazolidinone
Codes: ABAC-011, (II)1116928-1-a
Application context (from source-drug indications)
HIV infectionAbacavir Sulfate艾滋病痴呆综合征Abacavir SulfateAtherosclerosisMuvalaplin脂类代谢紊乱MuvalaplinRenal impairmentMuvalaplin
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Abacavir Sulfate | Tier C — Watch / trade | - |
| Muvalaplin | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(S)-4-benzyloxazolidin-2-one→pent-4-enoic pivalic anhydride→(S)-4-benzyl-3-(pent-4-enoyl)oxazolidin-2-one→(S)-3-((2S,3R)-2-allyl-3-methylpent-4-enoyl)-4-benzyloxazolidin-2-one→ABAC-015→(S)-4-benzyl-3-((1R,2R)-2-hydroxycyclopentanecarbonyl)oxazolidin-2-one→(1R,5R)-5-(hydroxymethyl)cyclopent-2-enol→((1R,2R)-2-acetoxycyclopent-3-en-1-yl)methyl acetate→N6-cyclopropyl-9H-purine-2,6-diamine→((1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methyl acetate
(3R)-1-[(1,1-Dimethylethoxy)carbonyl]-3-pyrrolidineacetic acid→(S)-4-Phenylmethyl-2-oxazolidinone→(3R)-3-[2-Oxo-2-[(4S)-2-oxo-4-(phenylmethyl)-3-oxazolidinyl]ethyl]-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester→1-Bromo-3-(bromomethyl)benzene→(3R)-3-[(1S)-1-[(3-Bromophenyl)methyl]-2-oxo-2-[(4S)-2-oxo-4-(phenylmethyl)-3-oxazolidinyl]ethyl]-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester→(2S)-3-(3-Bromophenyl)-2-[(3R)-1-(tert-butoxycarbonyl)pyrrolidin-3-yl]propanoic acid→Ammonium (2S)-3-(3-bromophenyl)-2-[(3R)-1-(tert-butoxycarbonyl)pyrrolidin-3-yl]propanoate→(alphaS,3R)-alpha-[(3-Bromophenyl)methyl]-1-[(1,1-dimethylethoxy)carbonyl]-3-pyrrolidineacetic acid 1,1-dimethylethyl ester→1,1,3-Trioxo-1,2-benzothiazole-2-carbaldehyde→(alphaS,3R)-1-[(1,1-Dimethylethoxy)carbonyl]-alpha-[(3-formylphenyl)methyl]-3-pyrrolidineacetic acid 1,1-dimethylethyl ester→Amino alcohol hydrochloride→(alphaS,3R)-1-[(1,1-Dimethylethoxy)carbonyl]-alpha-[[3-[(E)-(hydroxyimino)methyl]phenyl]methyl]-3-pyrrolidineacetic acid 1,1-dimethylethyl ester→1,1-Dimethylethyl (alphaS,3R)-alpha-[[3-(aminomethyl)phenyl]methyl]-1-[(1,1-dimethylethoxy)carbonyl]-3-pyrrolidineacetate
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