亚胺培南

Tier C · 观察 / 贸易

Imipenem

深圳市海滨制药有限公司

原研

1985

首批上市

到期年（公开口径）

无销量数据

峰值销售

化学药

类型

靶点：PBPs

适应症（已批准）：细菌感染、淋病、炭疽杆菌感染

各地区研发/上市状态

美国

欧盟

中国

批准上市

2005-12-01

日本

生产该 API 的工厂1

口径：平台供应网络（富通询价明细 + 产品主档）中登记生产该品种的工厂（在产口径），按报价活跃度排序；快照不含成本与客户信息。

已收录 1 家在产工厂名单，登录后可见（工厂信息不对未登录访客展示）。

登录查看工厂名单 →

合成路线与中间体7 routes

原研路线 × 0优化路线（非专利）× 7工艺路线 × 0

路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。

优化Route 1步骤 1 · 总收率 /

Imipenem-00159995-64-1Imipenem-002—API · 亚胺培南

编号	CAS 号	中间体名称
Imipenem-001	59995-64-1	(5R,6S)-3-[(2-aminoethyl)sulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
Imipenem-002	-	methyl methanecarboximidate

优化Route 2步骤 7 · 总收率 /

Imipenem-00159995-64-1Imipenem-002—API · 亚胺培南

编号	CAS 号	中间体名称
Imipenem-001	59995-64-1	(5R,6S)-3-[(2-aminoethyl)sulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
Imipenem-002	-	methyl methanecarboximidate

优化Route 3步骤 9 · 总收率 /

Imipenem-015104-94-9Imipenem-016371-40-4Imipenem-017106-40-1Imipenem-018156-43-4Imipenem-01970-11-1Imipenem-02078-95-5Imipenem-02118276-97-6Imipenem-0225469-26-1Imipenem-0235883-82-9Imipenem-024214285-87-7Imipenem-0251426146-10-2Imipenem-0261426146-05-5Imipenem-0271426146-15-7Imipenem-028—Imipenem-029—Imipenem-030—Imipenem-031—Imipenem-032—Imipenem-03386561-72-0Imipenem-03472-19-5Imipenem-03594944-06-6Imipenem-036104421-31-0Imipenem-0371426146-11-3Imipenem-0381426146-06-6Imipenem-0391426146-16-8Imipenem-040—Imipenem-041—Imipenem-042—Imipenem-043—Imipenem-044—Imipenem-0452211955-41-6Imipenem-046141781-29-5Imipenem-047203252-14-6Imipenem-0481426146-14-6Imipenem-0491426146-09-9Imipenem-0501426146-19-1Imipenem-051106399-63-7Imipenem-00376855-69-1API · 亚胺培南

编号	CAS 号	中间体名称
Imipenem-015	104-94-9	4-Methoxyphenylamine
Imipenem-016	371-40-4 在售	1-Amino-4-fluorobenzene
Imipenem-017	106-40-1 在售	4-Bromophenylamine
Imipenem-018	156-43-4	4-Ethoxyphenylamine
Imipenem-019	70-11-1	omega-Bromoacetophenone
Imipenem-020	78-95-5	Chloroacetyl chloride
Imipenem-021	18276-97-6	2-Iodo-1-(3-methoxyphenyl)ethanone
Imipenem-022	5469-26-1	1-Bromo-3,3-dimethylbutan-2-one<-fgf->
Imipenem-023	5883-82-9	2-[(4-Methoxyphenyl)amino]-1-phenylethanone
Imipenem-024	214285-87-7	1-[(4-Methoxyphenyl)amino]acetone
Imipenem-025	1426146-10-2	1-[(4-Fluorophenyl)amino]acetone
Imipenem-026	1426146-05-5	2-[(4-Bromophenyl)amino]-1-(3-methoxyphenyl)ethanone
Imipenem-027	1426146-15-7	1-[(4-Ethoxyphenyl)amino]-3,3-dimethylbutan-2-one
Imipenem-028	-	(3S)-4-Benzoyl-3-[(1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl]-1-(4-methoxyphenyl)azetidin-2-one
Imipenem-029	-	(3S)-4-Acetyl-3-[(1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl]-1-(4-methoxyphenyl)azetidin-2-one
Imipenem-030	-	(3S)-4-Acetyl-3-[(1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl]-1-(4-fluorophenyl)azetidin-2-one
Imipenem-031	-	(3S)-1-(4-Bromophenyl)-3-[(1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl]-4-(3-methoxybenzoyl)azetidin-2-one
Imipenem-032	-	(3S)-3-[(1R)-1-[[tert-Butyl(dimethyl)silyl]oxy]ethyl]-4-(2,2-dimethylpropanoyl)-1-(4-ethoxyphenyl)azetidin-2-one
Imipenem-033	86561-72-0	(2R,3R)-3-Methyloxirane-2-carboxylic acid
Imipenem-034	72-19-5	L-Threonine
Imipenem-035	94944-06-6	(2R,3R)-N-(4-Methoxyphenyl)-3-methyl-N-(2-oxo-2-phenylethyl)oxirane-2-carboxamide
Imipenem-036	104421-31-0	(2R,3R)-N-(4-Methoxyphenyl)-3-methyl-N-(2-oxopropyl)oxirane-2-carboxamide
Imipenem-037	1426146-11-3	(2R,3R)-N-(4-Fluorophenyl)-3-methyl-N-(2-oxopropyl)oxirane-2-carboxamide
Imipenem-038	1426146-06-6	(2R,3R)-N-(4-Bromophenyl)-N-[2-(3-methoxyphenyl)-2-oxoethyl]-3-methyloxirane-2-carboxamide
Imipenem-039	1426146-16-8	(2R,3R)-N-(3,3-Dimethyl-2-oxobutyl)-N-(4-ethoxyphenyl)-3-methyloxirane-2-carboxamide
Imipenem-040	-	(3S)-4-Benzoyl-3-[(1R)-1-hydroxyethyl]-1-(4-methoxyphenyl)azetidin-2-one
Imipenem-041	-	(3S)-4-Acetyl-3-[(1R)-1-hydroxyethyl]-1-(4-methoxyphenyl)azetidin-2-one
Imipenem-042	-	(3S)-4-Acetyl-1-(4-fluorophenyl)-3-[(1R)-1-hydroxyethyl]azetidin-2-one
Imipenem-043	-	(3S)-1-(4-Bromophenyl)-3-[(1R)-1-hydroxyethyl]-4-(3-methoxybenzoyl)azetidin-2-one
Imipenem-044	-	(3S)-4-(2,2-Dimethylpropanoyl)-1-(4-ethoxyphenyl)-3-[(1R)-1-hydroxyethyl]azetidin-2-one
Imipenem-045	2211955-41-6	(1E)-1-[(4-Methoxyphenyl)imino]acetone
Imipenem-046	141781-29-5	S-Pyridin-2-yl (3R)-3-[[tert-butyl(dimethyl)silyl]oxy]butanethioate
Imipenem-047	203252-14-6	(2R,3R)-3-[(1R)-1-[[tert-Butyl(dimethyl)silyl]oxy]ethyl]-1-(4-methoxyphenyl)-4-oxoazetidin-2-yl acetate
Imipenem-048	1426146-14-6	(2R,3R)-3-[(1R)-1-[[tert-Butyl(dimethyl)silyl]oxy]ethyl]-1-(4-fluorophenyl)-4-oxoazetidin-2-yl acetate
Imipenem-049	1426146-09-9	(2R,3R)-1-(4-Bromophenyl)-3-[(1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl]-4-oxoazetidin-2-yl acetate
Imipenem-050	1426146-19-1	(2R,3R)-3-[(1R)-1-[[tert-Butyl(dimethyl)silyl]oxy]ethyl]-1-(4-ethoxyphenyl)-4-oxoazetidin-2-yl acetate
Imipenem-051	106399-63-7	(2S,3S)-3-[(1R)-1-[[tert-Butyl(dimethyl)silyl]oxy]ethyl]-1-(4-methoxyphenyl)-4-oxoazetidine-2-carboxylic acid
Imipenem-003	76855-69-1	(2R,3R)-3-[(1R)-1-[[tert-Butyl(dimethyl)silyl]oxy]ethyl]-4-oxoazetidin-2-yl acetate

优化Route 4步骤 4 · 总收率 /

Imipenem-052854684-54-1Imipenem-053854684-53-0Imipenem-054442847-69-0Imipenem-055—Imipenem-0562249962-68-1Imipenem-0572249962-67-0Imipenem-058854684-55-2Imipenem-00874288-40-7Imipenem-0092524-64-3Imipenem-01075321-08-3Imipenem-01160-23-1,156-57-0Imipenem-01285737-65-1Imipenem-014127608-39-3API · 亚胺培南

编号	CAS 号	中间体名称
Imipenem-052	854684-54-1	(4-Methoxyphenyl)methyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylate
Imipenem-053	854684-53-0	(4-Methoxyphenyl)methyl (5R,6S)-3-[(diphenoxyphosphoryl)oxy]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
Imipenem-054	442847-69-0	4-Nitrobenzyl (5R,6S)-3-[(2-aminoethyl)sulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate hydrochloride
Imipenem-055	-	(4-Methoxyphenyl)methyl (5R,6S)-3-[(2-aminoethyl)sulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate--hydrogen chloride (1/1)
Imipenem-056	2249962-68-1	(4-Methoxyphenyl)methyl methanimidate
Imipenem-057	2249962-67-0	(4-Nitrophenyl)methyl methanimidate
Imipenem-058	854684-55-2	(4-Methoxyphenyl)methyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-3-([2-[(iminomethyl)amino]ethyl]sulfanyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
Imipenem-008	74288-40-7	(5R,6S)-6-[1(R)-Hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4-nitrobenzyl ester
Imipenem-009	2524-64-3	Diphenyl chlorophosphate
Imipenem-010	75321-08-3	4-Nitrobenzyl (5R,6S)-3-[(diphenoxyphosphoryl)oxy]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
Imipenem-011	60-23-1,156-57-0	Cysteaminium chloride
Imipenem-012	85737-65-1	Benzyl imidoformate
Imipenem-014	127608-39-3	(5R,6S)-6-[1(R)-Hydroxyethyl]-3-[2-(iminomethylamino)ethylsulfanyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitrobenzyl ester

优化Route 5步骤 6 · 总收率 /

Imipenem-059126579-20-2Imipenem-0602043074-82-2Imipenem-0612043074-46-8Imipenem-062156-57-0,60-23-1Imipenem-0632043074-48-0Imipenem-00376855-69-1Imipenem-00493788-47-7Imipenem-00593861-39-3Imipenem-01360099-09-4API · 亚胺培南

编号	CAS 号	中间体名称
Imipenem-059	126579-20-2	4-Nitrobenzyl (5R,6S)-6-[(1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylate
Imipenem-060	2043074-82-2	4-Nitrobenzyl (5R,6S)-6-[(1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl]-3-([2-[(iminomethyl)amino]ethyl]sulfanyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate hydrogen chloride
Imipenem-061	2043074-46-8	4-Nitrobenzyl (5R,6S)-6-[(1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl]-3-[(diphenoxyphosphoryl)oxy]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
Imipenem-062	156-57-0,60-23-1	2-Mercaptoethylamine hydrochloride
Imipenem-063	2043074-48-0	4-Nitrobenzyl (5R,6S)-3-[(2-aminoethyl)sulfanyl]-6-[(1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate hydrogen chloride
Imipenem-003	76855-69-1	2(R)-Acetoxy-3(R)-[O-TBDMS-1(R)-hydroxyethyl]-4-azetidinone
Imipenem-004	93788-47-7	(4-Nitrophenyl)methyl 2-diazo-3-[(trimethylsilyl)oxy]but-3-enoate
Imipenem-005	93861-39-3	4-[3(S)-[1(R)-[tert-Butyl(dimethyl)silyloxy]ethyl]-4-oxoazetidin-2(R)-yl]-2-diazo-3-oxobutyric acid 4-nitrobenzyl ester
Imipenem-013	60099-09-4	Benzyl imidoformate hydrogen chloride

优化Route 6步骤 3 · 总收率 /

Imipenem-064124-68-5Imipenem-065503-38-8Imipenem-06626654-39-7Imipenem-067563-76-8Imipenem-068114341-88-7API · 亚胺培南

编号	CAS 号	中间体名称
Imipenem-064	124-68-5 在售	2,2-Dimethylaminoethanol
Imipenem-065	503-38-8	Chloridocarbonic acid trichloromethyl ester
Imipenem-066	26654-39-7	4,4-Dimethyl-1,3-oxazolidin-2-one
Imipenem-067	563-76-8	2-Bromopropanoyl bromide
Imipenem-068	114341-88-7	3-(2-Bromopropanoyl)-4,4-dimethyl-1,3-oxazolidin-2-one

优化Route 7步骤 2 · 总收率 /

Imipenem-069—Imipenem-070442847-70-3Imipenem-01360099-09-4API · 亚胺培南

编号	CAS 号	中间体名称
Imipenem-069	-	(4-Nitrophenyl)methyl (5R,6S)-3-[(2-aminoethyl)sulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate 1-methylpyrrolidin-2-one hydrogen chloride
Imipenem-070	442847-70-3	(4-Nitrophenyl)methyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-3-([2-[(iminomethyl)amino]ethyl]sulfanyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate hydrogen chloride
Imipenem-013	60099-09-4	Benzyl imidoformate hydrogen chloride

常见问题（FAQ）

亚胺培南的适应症有哪些？

已批准的适应症包括：细菌感染、淋病、炭疽杆菌感染。

亚胺培南的专利什么时候到期？

亚胺培南的专利到期年暂无公开口径，本页会在数据管道核实后更新。

亚胺培南有几条合成路线？

本站收录 7 条合成路线，最短路线 1 步、总收率 /。每条路线的中间体均带登记编号与 CAS 号。

亚胺培南的关键中间体在哪里可以采购？

亚胺培南的多条路线中间体已挂接 CAS 档案，其中 3 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。

如何获取亚胺培南中间体的报价？

在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。

数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-22