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福沙那韦钙
Tier C · 观察 / 贸易Fosamprenavir Calcium
Vertex Pharmaceuticals Incorporated
原研
2003
首批上市
-
到期年（公开口径）
无销量数据
峰值销售
化学药
类型
靶点：HIV-1 protease
商品名：Telzir、Lexiva
适应症（已批准）：HIV感染
各地区研发/上市状态
美国
撤市
欧盟
撤市
中国
-
日本
批准上市
2004-12-24
合成路线与中间体5 routes
原研路线 × 1优化路线（非专利）× 4工艺路线 × 0
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
原研Route 1步骤 5 · 总收率 12.40 mg
FOSAC-001160232-08-6FOSAC-002160232-10-0FOSAC-003160232-11-1FOSAC-004138499-08-8FOSAC-005160232-12-2FOSAC-006160232-13-3FOSAC-00798-74-8FOSAC-008160231-69-6API · 福沙那韦钙
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| FOSAC-001 | 160232-08-6 | tert-butyl ((2S,3R)-3-hydroxy-4-(isobutylamino)-1-phenylbutan-2-yl)carbamate |
| FOSAC-002 | 160232-10-0 | benzyl ((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)(isobutyl)carbamate |
| FOSAC-003 | 160232-11-1 | benzyl ((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)(isobutyl)carbamate hydrochloride |
| FOSAC-004 | 138499-08-8 | (S)-2,5-dioxopyrrolidin-1-yl (tetrahydrofuran-3-yl) carbonate |
| FOSAC-005 | 160232-12-2 | benzyl ((2R,3S)-2-hydroxy-4-phenyl-3-(((((S)-tetrahydrofuran-3-yl)oxy)carbonyl)amino)butyl)(isobutyl)carbamate |
| FOSAC-006 | 160232-13-3 | (S)-tetrahydrofuran-3-yl ((2S,3R)-3-hydroxy-4-(isobutylamino)-1-phenylbutan-2-yl)carbamate |
| FOSAC-007 | 98-74-8 | 4-nitrobenzenesulfonyl chloride |
| FOSAC-008 | 160231-69-6 | (S)-tetrahydrofuran-3-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-nitrophenylsulfonamido)-1-phenylbutan-2-yl)carbamate |
优化Route 2步骤 10 · 总收率 7.52 g
FOSAC-001160232-08-6FOSAC-00798-74-8FOSAC-008160231-69-6FOSAC-00963-91-2FOSAC-010111060-64-1FOSAC-011166987-15-1FOSAC-012166987-16-2FOSAC-01398737-29-2FOSAC-014244634-31-9FOSAC-015317345-83-8FOSAC-016229495-87-8FOSAC-017229495-86-7API · 福沙那韦钙
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| FOSAC-001 | 160232-08-6 | tert-butyl ((2S,3R)-3-hydroxy-4-(isobutylamino)-1-phenylbutan-2-yl)carbamate |
| FOSAC-007 | 98-74-8 | 4-nitrobenzenesulfonyl chloride |
| FOSAC-008 | 160231-69-6 | (S)-tetrahydrofuran-3-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-nitrophenylsulfonamido)-1-phenylbutan-2-yl)carbamate |
| FOSAC-009 | 63-91-2 | L-phenylalanine |
| FOSAC-010 | 111060-64-1 | (S)-2-(dibenzylamino)-3-phenylpropanal |
| FOSAC-011 | 166987-15-1 | (2S,3S)-1-chloro-3-(dibenzylamino)-4-phenylbutan-2-ol hydrochloride |
| FOSAC-012 | 166987-16-2 | (2S,3S)-3-amino-1-chloro-4-phenylbutan-2-ol hydrochloride |
| FOSAC-013 | 98737-29-2 | tert-butyl ((S)-1-((S)-oxiran-2-yl)-2-phenylethyl)carbamate |
| FOSAC-014 | 244634-31-9 | N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutyl-4-nitrobenzenesulfonamide hydrochloride |
| FOSAC-015 | 317345-83-8 | (S)-tetrahydrofuran-3-yl 1H-imidazole-1-carboxylate |
| FOSAC-016 | 229495-87-8 | (S)-tetrahydrofuran-3-yl ((2S,3R)-4-((N-isobutyl-4-nitrophenyl)sulfonamido)-1-phenyl-3-(phosphonooxy)butan-2-yl)carbamate |
| FOSAC-017 | 229495-86-7 | (S)-tetrahydrofuran-3-yl ((2S,3R)-4-((4-amino-N-isobutylphenyl)sulfonamido)-1-phenyl-3-(phosphonooxy)butan-2-yl)carbamate |
优化Route 3步骤 4 · 总收率 25.8 kg
FOSAC-008160231-69-6FOSAC-016229495-87-8FOSAC-018229495-86-7API · 福沙那韦钙
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| FOSAC-008 | 160231-69-6 | (S)-tetrahydrofuran-3-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-nitrophenylsulfonamido)-1-phenylbutan-2-yl)carbamate |
| FOSAC-016 | 229495-87-8 | (S)-tetrahydrofuran-3-yl ((2S,3R)-4-((N-isobutyl-4-nitrophenyl)sulfonamido)-1-phenyl-3-(phosphonooxy)butan-2-yl)carbamate |
| FOSAC-018 | 229495-86-7 | (S)-tetrahydrofuran-3-yl ((2S,3R)-4-((4-amino-N-isobutylphenyl)sulfonamido)-1-phenyl-3-(phosphonooxy)butan-2-yl)carbamate |
优化Route 4步骤 6 · 总收率 5.00 g
FOSAC-001160232-08-6FOSAC-01398737-29-2FOSAC-015317345-83-8FOSAC-017229495-86-7FOSAC-0194435-59-0FOSAC-0201333313-44-2FOSAC-021190444-93-0FOSAC-0221333313-45-3API · 福沙那韦钙
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| FOSAC-001 | 160232-08-6 | tert-butyl ((2S,3R)-3-hydroxy-4-(isobutylamino)-1-phenylbutan-2-yl)carbamate |
| FOSAC-013 | 98737-29-2 | tert-butyl ((S)-1-((S)-oxiran-2-yl)-2-phenylethyl)carbamate |
| FOSAC-015 | 317345-83-8 | (S)-tetrahydrofuran-3-yl 1H-imidazole-1-carboxylate |
| FOSAC-017 | 229495-86-7 | (S)-tetrahydrofuran-3-yl ((2S,3R)-4-((4-amino-N-isobutylphenyl)sulfonamido)-1-phenyl-3-(phosphonooxy)butan-2-yl)carbamate |
| FOSAC-019 | 4435-59-0 | 4-(1,3-dioxoisoindolin-2-yl)benzenesulfonyl chloride |
| FOSAC-020 | 1333313-44-2 | N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-4-(1,3-dioxoisoindolin-2-yl)-N-isobutylbenzenesulfonamide hydrochloride |
| FOSAC-021 | 190444-93-0 | (S)-tetrahydrofuran-3-yl ((2S,3R)-4-((4-(1,3-dioxoisoindolin-2-yl)-N-isobutylphenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate |
| FOSAC-022 | 1333313-45-3 | (S)-tetrahydrofuran-3-yl ((2S,3R)-4-((4-(1,3-dioxoisoindolin-2-yl)-N-isobutylphenyl)sulfonamido)-1-phenyl-3-(phosphonooxy)butan-2-yl)carbamate |
优化Route 5步骤 8 · 总收率 0.04 g
FOSAC-00798-74-8FOSAC-008160231-69-6FOSAC-02342238-15-3FOSAC-02485531-71-1FOSAC-0251824396-02-2FOSAC-0261824298-01-2FOSAC-027188264-84-8FOSAC-028136465-89-9FOSAC-029206361-96-8FOSAC-0301394027-31-6FOSAC-031187946-12-9FOSAC-032—API · 福沙那韦钙
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| FOSAC-007 | 98-74-8 | 4-nitrobenzenesulfonyl chloride |
| FOSAC-008 | 160231-69-6 | (S)-tetrahydrofuran-3-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-nitrophenylsulfonamido)-1-phenylbutan-2-yl)carbamate |
| FOSAC-023 | 42238-15-3 | (E)-4-phenylbut-2-en-1-ol |
| FOSAC-024 | 85531-71-1 | (3-benzyloxiran-2-yl)methanol |
| FOSAC-025 | 1824396-02-2 | 3-azido-4-phenylbutane-1,2-diol |
| FOSAC-026 | 1824298-01-2 | 2-(1-azido-2-phenylethyl)oxirane |
| FOSAC-027 | 188264-84-8 | Cobalt, [[2,2'-[(1S,2S)-1,2-cyclohexanediylbis[(nitrilo-kN)methylidyne]]bis[4,6-bis(1,1-dimethylethyl)phenolato-kO]](2-)]-, (SP-4-2)- |
| FOSAC-028 | 136465-89-9 | (S)-2-((S)-1-azido-2-phenylethyl)oxirane |
| FOSAC-029 | 206361-96-8 | (2R,3S)-3-azido-1-(isobutylamino)-4-phenylbutan-2-ol |
| FOSAC-030 | 1394027-31-6 | N-((2R,3S)-3-azido-2-hydroxy-4-phenylbutyl)-N-isobutyl-4-nitrobenzenesulfonamide |
| FOSAC-031 | 187946-12-9 | (S)-tetrahydrofuran-3-yl 2,5-dioxopyrrolidine-1-carboxylate |
| FOSAC-032 | - | (S)-tetrahydrofuran-3-yl ((2S,3R)-4-((4-amino-N-isobutylphenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate |
常见问题（FAQ）
福沙那韦钙的适应症有哪些？
已批准的适应症包括：HIV感染。
福沙那韦钙的专利什么时候到期？
福沙那韦钙的专利到期年暂无公开口径，本页会在数据管道核实后更新。
福沙那韦钙有几条合成路线？
本站收录 5 条合成路线，最短路线 4 步、总收率 25.8 kg。每条路线的中间体均带登记编号与 CAS 号。
福沙那韦钙的关键中间体在哪里可以采购？
福沙那韦钙路线中的中间体均已建立 CAS 档案，可直接按 CAS 发起询价，需求会进入供应网络撮合池。
如何获取福沙那韦钙中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-22