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索磷布韦/维帕他韦
Tier B · 提前布局Sofosbuvir/Velpatasvir
Gilead Inc
原研
2016
首批上市
-
到期年（公开口径）
$3.51B ▲
峰值销售
化学药
类型
靶点：NS5B、NS5A
商品名：Epclusa、丙通沙
适应症（已批准）：丙型肝炎、慢性丙型肝炎
各地区研发/上市状态
美国
批准上市
2016-06-28
欧盟
批准上市
2016-07-06
中国
批准上市
2018-05-23
日本
批准上市
2019-01-08
生产该 API 的工厂9
口径：平台供应网络（富通询价明细 + 产品主档）中登记生产该品种的工厂（在产口径），按报价活跃度排序；快照不含成本与客户信息。
已收录 9 家在产工厂名单，登录后可见（工厂信息不对未登录访客展示）。
登录查看工厂名单 →合成路线与中间体3 routes
原研路线 × 1优化路线（非专利）× 2工艺路线 × 0
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
原研Route 2步骤 6 · 总收率 57 mg
SOFO-004863329-66-2SOFO-00862062-65-1SOFO-0091160557-97-0SOFO-01040608-06-8SOFO-0111256490-32-0SOFO-0121256490-53-5SOFO-0131256490-49-9SOFO-0141256490-33-1SOFO-015108-95-2SOFO-016777-52-6API · 索磷布韦/维帕他韦
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| SOFO-004 | 863329-66-2在售 | 1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione |
| SOFO-008 | 62062-65-1在售 | (S)-isopropyl 2-aminopropanoate hydrochloride |
| SOFO-009 | 1160557-97-0在售 | 1-((2R,3R,4R,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3-fluoro-4-hydroxy-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione |
| SOFO-010 | 40608-06-8在售 | 4-oxopentanoic anhydride |
| SOFO-011 | 1256490-32-0在售 | (2R,3R,4R,5R)-2-(((tert-butyldimethylsilyl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-4-methyltetrahydrofuran-3-yl 4-oxopentanoate |
| SOFO-012 | 1256490-53-5在售 | (2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-yl 4-oxopentanoate |
| SOFO-013 | 1256490-49-9在售 | (S)-isopropyl 2-(((R)-(4-nitrophenoxy)(phenoxy)phosphoryl)amino)propanoate |
| SOFO-014 | 1256490-33-1在售 | (2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-((((S)-(((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)-4-methyltetrahydrofuran-3-yl 4-oxopentanoate |
| SOFO-015 | 108-95-2在售 | phenol |
| SOFO-016 | 777-52-6在售 | 4-nitrophenyl phosphorodichloridate |
优化Route 1步骤 6 · 总收率 10.5 g
SOFO-001817204-33-4SOFO-002817204-32-3SOFO-003863329-65-1SOFO-004863329-66-2SOFO-005261909-49-3SOFO-0061190307-88-0SOFO-007770-12-7SOFO-00862062-65-1API · 索磷布韦/维帕他韦
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| SOFO-001 | 817204-33-4在售 | 4-amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidin-2(1H)-one |
| SOFO-002 | 817204-32-3在售 | (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate |
| SOFO-003 | 863329-65-1在售 | ((2R,3R,4R,5R)-3-(benzoyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate |
| SOFO-004 | 863329-66-2在售 | 1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione |
| SOFO-005 | 261909-49-3在售 | (2S)-isopropyl 2-((chloro(phenoxy)phosphoryl)amino)propanoate |
| SOFO-006 | 1190307-88-0在售 | (2S)-isopropyl 2-(((((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate |
| SOFO-007 | 770-12-7在售 | phenyl phosphorodichloridate |
| SOFO-008 | 62062-65-1在售 | (S)-isopropyl 2-aminopropanoate hydrochloride |
优化Route 3步骤 11 · 总收率 6.9 g
SOFO-002817204-32-3SOFO-003863329-65-1SOFO-004863329-66-2SOFO-007770-12-7SOFO-00862062-65-1SOFO-01715186-48-8SOFO-0185717-37-3SOFO-01981997-76-4SOFO-02093635-76-8SOFO-0211033394-83-0SOFO-022879551-04-9SOFO-023874638-80-9SOFO-0241199809-23-8SOFO-02526661-13-2SOFO-0261334513-02-8API · 索磷布韦/维帕他韦
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| SOFO-002 | 817204-32-3在售 | (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate |
| SOFO-003 | 863329-65-1在售 | ((2R,3R,4R,5R)-3-(benzoyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate |
| SOFO-004 | 863329-66-2在售 | 1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione |
| SOFO-007 | 770-12-7在售 | phenyl phosphorodichloridate |
| SOFO-008 | 62062-65-1在售 | (S)-isopropyl 2-aminopropanoate hydrochloride |
| SOFO-017 | 15186-48-8在售 | (R)-2,2-dimethyl-1,3-dioxolane-4-carbaldehyde |
| SOFO-018 | 5717-37-3在售 | ethyl 2-(triphenylphosphoranylidene)propanoate |
| SOFO-019 | 81997-76-4在售 | (S,E)-ethyl 3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-methylacrylate |
| SOFO-020 | 93635-76-8在售 | (2S,3R)-ethyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,3-dihydroxy-2-methylpropanoate |
| SOFO-021 | 1033394-83-0在售 | (2R,3R)-ethyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-fluoro-3-hydroxy-2-methylpropanoate |
| SOFO-022 | 879551-04-9在售 | (3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyldihydrofuran-2(3H)-one |
| SOFO-023 | 874638-80-9在售 | ((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate |
| SOFO-024 | 1199809-23-8在售 | ((2R,3R,4R)-3-(benzoyloxy)-5-chloro-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate |
| SOFO-025 | 26661-13-2在售 | N-(2-oxo-1,2-dihydropyrimidin-4-yl)benzamide |
| SOFO-026 | 1334513-02-8在售 | (S)-isopropyl 2-(((S)-(perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate |
常见问题（FAQ）
索磷布韦/维帕他韦的适应症有哪些？
已批准的适应症包括：丙型肝炎、慢性丙型肝炎。
索磷布韦/维帕他韦的专利什么时候到期？
索磷布韦/维帕他韦的专利到期年暂无公开口径，本页会在数据管道核实后更新。
索磷布韦/维帕他韦有几条合成路线？
本站收录 3 条合成路线，最短路线 6 步、总收率 10.5 g。每条路线的中间体均带登记编号与 CAS 号。
索磷布韦/维帕他韦的关键中间体在哪里可以采购？
索磷布韦/维帕他韦的多条路线中间体已挂接 CAS 档案，其中 26 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。
如何获取索磷布韦/维帕他韦中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-22