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盐酸头孢卡品酯
Tier C · 观察 / 贸易Cefcamate Pivoxil Hydrochloride
盐野义制药株式会社
原研
1997
首批上市
-
到期年（公开口径）
无销量数据
峰值销售
化学药
类型
靶点：PBPs
商品名：Flomox、Flumax
适应症（已批准）：细菌感染
各地区研发/上市状态
美国
-
欧盟
-
中国
批准上市
2010-12-31
日本
批准上市
1997-06-01
合成路线与中间体7 routes
原研路线 × 0优化路线（非专利）× 7工艺路线 × 0
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
优化Route 1步骤 7 · 总收率 120.1g(Cefcamate Pivoxil Hydrochloride (API))
Cefcamate Pivoxil Hydrochloride-001943222-09-1Cefcamate Pivoxil Hydrochloride-002—Cefcamate Pivoxil Hydrochloride-003158743-37-4Cefcamate Pivoxil Hydrochloride-00486978-24-7Cefcamate Pivoxil Hydrochloride-00515690-38-7Cefcamate Pivoxil Hydrochloride-006—Cefcamate Pivoxil Hydrochloride-007153012-25-0Cefcamate Pivoxil Hydrochloride-0081189-71-5Cefcamate Pivoxil Hydrochloride-0093019-71-4Cefcamate Pivoxil Hydrochloride-010153012-37-4Cefcamate Pivoxil Hydrochloride-011—Cefcamate Pivoxil Hydrochloride-012105890-10-6Cefcamate Pivoxil Hydrochloride-013135889-00-8Cefcamate Pivoxil Hydrochloride-0142227302-44-3Cefcamate Pivoxil Hydrochloride-01553064-79-2Cefcamate Pivoxil Hydrochloride-016105889-45-0API · 盐酸头孢卡品酯
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Cefcamate Pivoxil Hydrochloride-001 | 943222-09-1 | Ethyl2-(bromoacetyl)pent-2-enoate |
| Cefcamate Pivoxil Hydrochloride-002 | - | tert-Butylcarbamothioylcarbamatehydrobromide |
| Cefcamate Pivoxil Hydrochloride-003 | 158743-37-4 | Ethyl(2Z)-2-[2-[(tert-butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoate |
| Cefcamate Pivoxil Hydrochloride-004 | 86978-24-7 | 2-[2(Z)-2-Boc-amino-1,3-thiazol-4-yl]pent-2-enoicacid |
| Cefcamate Pivoxil Hydrochloride-005 | 15690-38-7 | (6R,7R)-7-Amino-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid |
| Cefcamate Pivoxil Hydrochloride-006 | - | (6R,7R)-7-[[(2Z)-2-[2-[(tert-Butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoyl]amino]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacidN,N,N',N'-tetramethylguanidine(11) |
| Cefcamate Pivoxil Hydrochloride-007 | 153012-25-0 | (6R,7R)-7-[[(2Z)-2-[2-[(tert-Butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoyl]amino]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid |
| Cefcamate Pivoxil Hydrochloride-008 | 1189-71-5 | Chlorosulfonicacidisocyanate |
| Cefcamate Pivoxil Hydrochloride-009 | 3019-71-4 | Trichloroacetylisocyanate |
| Cefcamate Pivoxil Hydrochloride-010 | 153012-37-4 | (6R,7R)-7-[[(2Z)-2-[2-[(tert-Butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoyl]amino]-3-[(carbamoyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacidN-(propan-2-yl)propan-2-amine |
| Cefcamate Pivoxil Hydrochloride-011 | - | Sodium(6R,7R)-7-[[(2Z)-2-[2-[(tert-butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoyl]amino]-3-[(carbamoyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| Cefcamate Pivoxil Hydrochloride-012 | 105890-10-6 | (6R,7R)-7-[[(2Z)-2-[2-[(tert-Butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoyl]amino]-3-[(carbamoyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid |
| Cefcamate Pivoxil Hydrochloride-013 | 135889-00-8 | (6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-pentenoylamino]-3-(carbamoyloxymethyl)-3-cephem-4-carboxylicacid |
| Cefcamate Pivoxil Hydrochloride-014 | 2227302-44-3 | (6R,7R)-7-[[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)pent-2-enoyl]amino]-3-[(carbamoyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacidhydrogenchloride |
| Cefcamate Pivoxil Hydrochloride-015 | 53064-79-2在售 | Iodomethylpivalate |
| Cefcamate Pivoxil Hydrochloride-016 | 105889-45-0 | [(2,2-Dimethylpropanoyl)oxy]methyl(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)pent-2-enoyl]amino]-3-[(carbamoyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
优化Route 2步骤 5 · 总收率 23.5g(Cefcamate Pivoxil Hydrochloride-013)
Cefcamate Pivoxil Hydrochloride-00515690-38-7Cefcamate Pivoxil Hydrochloride-0081189-71-5Cefcamate Pivoxil Hydrochloride-013135889-00-8Cefcamate Pivoxil Hydrochloride-017267881-71-0Cefcamate Pivoxil Hydrochloride-018—Cefcamate Pivoxil Hydrochloride-019—Cefcamate Pivoxil Hydrochloride-020—Cefcamate Pivoxil Hydrochloride-021—API · 盐酸头孢卡品酯
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Cefcamate Pivoxil Hydrochloride-005 | 15690-38-7 | (6R,7R)-7-Amino-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid |
| Cefcamate Pivoxil Hydrochloride-008 | 1189-71-5 | Chlorosulfonicacidisocyanate |
| Cefcamate Pivoxil Hydrochloride-013 | 135889-00-8 | (6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-pentenoylamino]-3-(carbamoyloxymethyl)-3-cephem-4-carboxylicacid |
| Cefcamate Pivoxil Hydrochloride-017 | 267881-71-0 | Methyl(2Z)-2-(2-amino-1,3-thiazol-4-yl)pent-2-enoate |
| Cefcamate Pivoxil Hydrochloride-018 | - | Methyl(2Z)-2-[2-(2-phenylacetamido)-1,3-thiazol-4-yl]pent-2-enoate |
| Cefcamate Pivoxil Hydrochloride-019 | - | (2Z)-2-[2-(2-Phenylacetamido)-1,3-thiazol-4-yl]pent-2-enoicacid |
| Cefcamate Pivoxil Hydrochloride-020 | - | (6R)-3-[(Carbamoyloxy)methyl]-8-oxo-7-([(2Z)-2-[2-(2-phenylacetamido)-1,3-thiazol-4-yl]pent-2-enoyl]amino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid--N-(propan-2-yl)propan-2-amine(11) |
| Cefcamate Pivoxil Hydrochloride-021 | - | Sodium(6R)-3-[(carbamoyloxy)methyl]-8-oxo-7-([(2Z)-2-[2-(2-phenylacetamido)-1,3-thiazol-4-yl]pent-2-enoyl]amino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
优化Route 3步骤 7 · 总收率 6.375g(Cefcamate Pivoxil Hydrochloride (API))
Cefcamate Pivoxil Hydrochloride-001943222-09-1Cefcamate Pivoxil Hydrochloride-002—Cefcamate Pivoxil Hydrochloride-003158743-37-4Cefcamate Pivoxil Hydrochloride-00486978-24-7Cefcamate Pivoxil Hydrochloride-00515690-38-7Cefcamate Pivoxil Hydrochloride-007153012-25-0Cefcamate Pivoxil Hydrochloride-011—Cefcamate Pivoxil Hydrochloride-012105890-10-6Cefcamate Pivoxil Hydrochloride-013135889-00-8Cefcamate Pivoxil Hydrochloride-0142227302-44-3Cefcamate Pivoxil Hydrochloride-01553064-79-2Cefcamate Pivoxil Hydrochloride-016105889-45-0API · 盐酸头孢卡品酯
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Cefcamate Pivoxil Hydrochloride-001 | 943222-09-1 | Ethyl2-(bromoacetyl)pent-2-enoate |
| Cefcamate Pivoxil Hydrochloride-002 | - | tert-Butylcarbamothioylcarbamatehydrobromide |
| Cefcamate Pivoxil Hydrochloride-003 | 158743-37-4 | Ethyl(2Z)-2-[2-[(tert-butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoate |
| Cefcamate Pivoxil Hydrochloride-004 | 86978-24-7 | 2-[2(Z)-2-Boc-amino-1,3-thiazol-4-yl]pent-2-enoicacid |
| Cefcamate Pivoxil Hydrochloride-005 | 15690-38-7 | (6R,7R)-7-Amino-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid |
| Cefcamate Pivoxil Hydrochloride-007 | 153012-25-0 | (6R,7R)-7-[[(2Z)-2-[2-[(tert-Butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoyl]amino]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid |
| Cefcamate Pivoxil Hydrochloride-011 | - | Sodium(6R,7R)-7-[[(2Z)-2-[2-[(tert-butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoyl]amino]-3-[(carbamoyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| Cefcamate Pivoxil Hydrochloride-012 | 105890-10-6 | (6R,7R)-7-[[(2Z)-2-[2-[(tert-Butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoyl]amino]-3-[(carbamoyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid |
| Cefcamate Pivoxil Hydrochloride-013 | 135889-00-8 | (6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-pentenoylamino]-3-(carbamoyloxymethyl)-3-cephem-4-carboxylicacid |
| Cefcamate Pivoxil Hydrochloride-014 | 2227302-44-3 | (6R,7R)-7-[[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)pent-2-enoyl]amino]-3-[(carbamoyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacidhydrogenchloride |
| Cefcamate Pivoxil Hydrochloride-015 | 53064-79-2在售 | Iodomethylpivalate |
| Cefcamate Pivoxil Hydrochloride-016 | 105889-45-0 | [(2,2-Dimethylpropanoyl)oxy]methyl(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)pent-2-enoyl]amino]-3-[(carbamoyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
优化Route 4步骤 8 · 总收率 14.6g(Cefcamate Pivoxil Hydrochloride (API))
Cefcamate Pivoxil Hydrochloride-00486978-24-7Cefcamate Pivoxil Hydrochloride-022153012-24-9Cefcamate Pivoxil Hydrochloride-023—Cefcamate Pivoxil Hydrochloride-024957-68-6Cefcamate Pivoxil Hydrochloride-025107185-27-3Cefcamate Pivoxil Hydrochloride-007153012-25-0Cefcamate Pivoxil Hydrochloride-00515690-38-7Cefcamate Pivoxil Hydrochloride-0081189-71-5Cefcamate Pivoxil Hydrochloride-010153012-37-4Cefcamate Pivoxil Hydrochloride-01553064-79-2Cefcamate Pivoxil Hydrochloride-026105889-80-3API · 盐酸头孢卡品酯
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Cefcamate Pivoxil Hydrochloride-004 | 86978-24-7 | 2-[2(Z)-2-Boc-amino-1,3-thiazol-4-yl]pent-2-enoicacid |
| Cefcamate Pivoxil Hydrochloride-022 | 153012-24-9 | tert-Butyl[4-[(2Z)-1-oxo-1-[(methylsulfonyl)oxy]pent-2-en-2-yl]-1,3-thiazol-2-yl]carbamate |
| Cefcamate Pivoxil Hydrochloride-023 | - | Methyl(2Z)-2-[2-[(tert-butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoatehydrogenchloride |
| Cefcamate Pivoxil Hydrochloride-024 | 957-68-6 | (6R,7R)-3-(Acetoxymethyl)-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| Cefcamate Pivoxil Hydrochloride-025 | 107185-27-3 | (6R,7R)-3-[(Acetyloxy)methyl]-7-[[(2Z)-2-[2-[(tert-butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid |
| Cefcamate Pivoxil Hydrochloride-007 | 153012-25-0 | (6R,7R)-7-[[(2Z)-2-[2-[(tert-Butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoyl]amino]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid |
| Cefcamate Pivoxil Hydrochloride-005 | 15690-38-7 | Hydroxymethyl-7-aminocephalosporanicacid |
| Cefcamate Pivoxil Hydrochloride-008 | 1189-71-5 | N-Carbonylsulfamylchloride |
| Cefcamate Pivoxil Hydrochloride-010 | 153012-37-4 | (6R,7R)-7-[[(2Z)-2-[2-[(tert-Butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoyl]amino]-3-[(carbamoyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacidN-(propan-2-yl)propan-2-amine |
| Cefcamate Pivoxil Hydrochloride-015 | 53064-79-2在售 | Iodomethylpivalate |
| Cefcamate Pivoxil Hydrochloride-026 | 105889-80-3 | Boc-cefcapenepivoxil |
优化Route 5步骤 1 · 总收率 184g(Cefcamate Pivoxil Hydrochloride-004)
Cefcamate Pivoxil Hydrochloride-027105-36-2Cefcamate Pivoxil Hydrochloride-02862-56-6Cefcamate Pivoxil Hydrochloride-029123-38-6Cefcamate Pivoxil Hydrochloride-00486978-24-7API · 盐酸头孢卡品酯
优化Route 6步骤 3 · 总收率 48.6g(Cefcamate Pivoxil Hydrochloride-004)
Cefcamate Pivoxil Hydrochloride-00486978-24-7Cefcamate Pivoxil Hydrochloride-030674-82-8Cefcamate Pivoxil Hydrochloride-03117790-81-7Cefcamate Pivoxil Hydrochloride-029123-38-6Cefcamate Pivoxil Hydrochloride-02862-56-6Cefcamate Pivoxil Hydrochloride-017267881-71-0Cefcamate Pivoxil Hydrochloride-03224424-99-5API · 盐酸头孢卡品酯
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Cefcamate Pivoxil Hydrochloride-004 | 86978-24-7 | 2-[2(Z)-2-Boc-amino-1,3-thiazol-4-yl]pent-2-enoicacid |
| Cefcamate Pivoxil Hydrochloride-030 | 674-82-8在售 | 4-Methyleneoxetan-2-one |
| Cefcamate Pivoxil Hydrochloride-031 | 17790-81-7 | Methyl4-bromo-3-oxobutanoate |
| Cefcamate Pivoxil Hydrochloride-029 | 123-38-6在售 | Propanal |
| Cefcamate Pivoxil Hydrochloride-028 | 62-56-6在售 | Thiocarbamide |
| Cefcamate Pivoxil Hydrochloride-017 | 267881-71-0 | Methyl(2Z)-2-(2-amino-1,3-thiazol-4-yl)pent-2-enoate |
| Cefcamate Pivoxil Hydrochloride-032 | 24424-99-5 | Di(tert-butyl)dicarbonate |
优化Route 7步骤 6 · 总收率 65-70g(Cefcamate Pivoxil Hydrochloride (API))
Cefcamate Pivoxil Hydrochloride-00515690-38-7Cefcamate Pivoxil Hydrochloride-033101182-24-5Cefcamate Pivoxil Hydrochloride-00486978-24-7Cefcamate Pivoxil Hydrochloride-0341093349-61-1Cefcamate Pivoxil Hydrochloride-0081189-71-5Cefcamate Pivoxil Hydrochloride-011—Cefcamate Pivoxil Hydrochloride-01553064-79-2Cefcamate Pivoxil Hydrochloride-03518997-19-8Cefcamate Pivoxil Hydrochloride-026105889-80-3API · 盐酸头孢卡品酯
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Cefcamate Pivoxil Hydrochloride-005 | 15690-38-7 | (6R,7R)-7-Amino-3-(hydroxymethyl)-3-cephem-4-carboxylicacid |
| Cefcamate Pivoxil Hydrochloride-033 | 101182-24-5 | Trimethylsilyl(6R,7R)-7-amino-8-oxo-3-[[(trimethylsilyl)oxy]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| Cefcamate Pivoxil Hydrochloride-004 | 86978-24-7 | 2-[2(Z)-2-Boc-amino-1,3-thiazol-4-yl]pent-2-enoicacid |
| Cefcamate Pivoxil Hydrochloride-034 | 1093349-61-1 | Trimethylsilyl(6R,7R)-7-[[2-[2-[(tert-butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoyl]amino]-8-oxo-3-[[(trimethylsilyl)oxy]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| Cefcamate Pivoxil Hydrochloride-008 | 1189-71-5 | Chlorosulfonicacidisocyanate |
| Cefcamate Pivoxil Hydrochloride-011 | - | Sodium(6R,7R)-7-[[(2Z)-2-[2-[(tert-butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoyl]amino]-3-[(carbamoyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| Cefcamate Pivoxil Hydrochloride-015 | 53064-79-2在售 | Iodomethylpivalate |
| Cefcamate Pivoxil Hydrochloride-035 | 18997-19-8 | Chloromethylpivalate |
| Cefcamate Pivoxil Hydrochloride-026 | 105889-80-3 | Boc-cefcapenepivoxil |
常见问题（FAQ）
盐酸头孢卡品酯的适应症有哪些？
已批准的适应症包括：细菌感染。
盐酸头孢卡品酯的专利什么时候到期？
盐酸头孢卡品酯的专利到期年暂无公开口径，本页会在数据管道核实后更新。
盐酸头孢卡品酯有几条合成路线？
本站收录 7 条合成路线，最短路线 1 步、总收率 184g(Cefcamate Pivoxil Hydrochloride-004)。每条路线的中间体均带登记编号与 CAS 号。
盐酸头孢卡品酯的关键中间体在哪里可以采购？
盐酸头孢卡品酯的多条路线中间体已挂接 CAS 档案，其中 5 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。
如何获取盐酸头孢卡品酯中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-22