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拉坦前列素
Tier C · 观察 / 贸易Latanoprost
辉瑞
原研
1996
首批上市
-
到期年（公开口径）
$0.23B ▲
峰值销售
化学药
类型
靶点：PTGFR
商品名：MicroProst、适利达、Latoprost、Xelpros、Monoprost、Catioprost、Xalatan、Eye-D
适应症（已批准）：高眼压、开角型青光眼
各地区研发/上市状态
美国
批准上市
1996-06-05
欧盟
批准上市
2023-11-15
中国
批准上市
1999-02-13
日本
批准上市
1999-03-12
合成路线与中间体4 routes
原研路线 × 1优化路线（非专利）× 3工艺路线 × 0
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
原研Route 1步骤 8 · 总收率 0.19 g
LATA-00131752-99-5LATA-00238754-71-1LATA-00341162-19-0LATA-00441639-72-9LATA-00541639-73-0LATA-006145667-74-9LATA-007145667-75-0LATA-008352276-28-9LATA-00917814-85-6LATA-01041639-83-2LATA-01175-30-9API · 拉坦前列素
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| LATA-001 | 31752-99-5 | (3aR,4S,5R,6aS)-4-(hydroxymethyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate |
| LATA-002 | 38754-71-1 | (3aR,4R,5R,6aS)-4-formyl-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate |
| LATA-003 | 41162-19-0 | dimethyl (2-oxo-4-phenylbutyl)phosphonate |
| LATA-004 | 41639-72-9 | (3aR,4R,5R,6aS)-2-oxo-4-((E)-3-oxo-5-phenylpent-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate |
| LATA-005 | 41639-73-0 | (3aR,4R,5R,6aS)-4-((S,E)-3-hydroxy-5-phenylpent-1-en-1-yl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate |
| LATA-006 | 145667-74-9 | (3aR,4R,5R,6aS)-4-((R)-3-hydroxy-5-phenylpentyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate |
| LATA-007 | 145667-75-0 | (3aR,4R,5R,6aS)-5-hydroxy-4-((R)-3-hydroxy-5-phenylpentyl)hexahydro-2H-cyclopenta[b]furan-2-one |
| LATA-008 | 352276-28-9 | (3aR,4R,5R,6aS)-4-((R)-3-hydroxy-5-phenylpentyl)hexahydro-2H-cyclopenta[b]furan-2,5-diol |
| LATA-009 | 17814-85-6 | (4-carboxybutyl)triphenylphosphonium bromide |
| LATA-010 | 41639-83-2 | (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoic acid |
| LATA-011 | 75-30-9 | 2-iodopropane |
优化Route 2步骤 10 · 总收率 /
LATA-008352276-28-9LATA-00917814-85-6LATA-01041639-83-2LATA-01175-30-9LATA-012591-87-7LATA-013122-97-4LATA-01498088-55-2LATA-0151379822-84-0LATA-016474944-31-5LATA-017876953-73-0LATA-018110-02-1LATA-019—LATA-020—LATA-0211644539-27-4LATA-0221644539-31-0API · 拉坦前列素
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| LATA-008 | 352276-28-9 | (3aR,4R,5R,6aS)-4-((R)-3-hydroxy-5-phenylpentyl)hexahydro-2H-cyclopenta[b]furan-2,5-diol |
| LATA-009 | 17814-85-6 | (4-carboxybutyl)triphenylphosphonium bromide |
| LATA-010 | 41639-83-2 | (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoic acid |
| LATA-011 | 75-30-9 | 2-iodopropane |
| LATA-012 | 591-87-7 | allyl acetate |
| LATA-013 | 122-97-4 | 3-phenylpropan-1-ol |
| LATA-014 | 98088-55-2 | (S)-1-phenylhex-5-en-3-ol |
| LATA-015 | 1379822-84-0 | (S)-tert-butyldimethyl((1-phenylhex-5-en-3-yl)oxy)silane |
| LATA-016 | 474944-31-5 | (S)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpentan-1-ol |
| LATA-017 | 876953-73-0 | (S)-tert-butyl((1-iodo-5-phenylpentan-3-yl)oxy)dimethylsilane |
| LATA-018 | 110-02-1 | thiophene |
| LATA-019 | - | - |
| LATA-020 | - | (3aR,6aS)-2-methoxy-3,3a,6,6a-tetrahydro-2H-cyclopenta[b]furan-5-carbaldehyde |
| LATA-021 | 1644539-27-4 | tert-butyl(((3R)-1-((3aR,4R,6aS,Z)-2-methoxy-5-(((trimethylsilyl)oxy)methylene)hexahydro-2H-cyclopenta[b]furan-4-yl)-5-phenylpentan-3-yl)oxy)dimethylsilane |
| LATA-022 | 1644539-31-0 | (3aR,4R,5R,6aS)-4-((R)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpentyl)-2-methoxyhexahydro-2H-cyclopenta[b]furan-5-ol |
优化Route 3步骤 8 · 总收率 /
LATA-00341162-19-0LATA-00917814-85-6LATA-01041639-83-2LATA-02364091-14-1LATA-0241240483-13-9LATA-0251240483-14-0LATA-0261240483-20-8LATA-0271240483-21-9LATA-0281240483-22-0LATA-0291240483-23-1LATA-03067-63-0API · 拉坦前列素
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| LATA-003 | 41162-19-0 | dimethyl (2-oxo-4-phenylbutyl)phosphonate |
| LATA-009 | 17814-85-6 | (4-carboxybutyl)triphenylphosphonium bromide |
| LATA-010 | 41639-83-2 | (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoic acid |
| LATA-023 | 64091-14-1 | (3aR,4R,5R,6aS)-5-((tert-butyldimethylsilyl)oxy)-2-oxohexahydro-2H-cyclopenta[b]furan-4-carbaldehyde |
| LATA-024 | 1240483-13-9 | (3aR,4R,5R,6aS)-5-((tert-butyldimethylsilyl)oxy)-4-((E)-3-oxo-5-phenylpent-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one |
| LATA-025 | 1240483-14-0 | (3aR,4R,5R,6aS)-5-((tert-butyldimethylsilyl)oxy)-4-((S,E)-3-hydroxy-5-phenylpent-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one |
| LATA-026 | 1240483-20-8 | (3aR,4R,5R,6aS)-5-((tert-butyldimethylsilyl)oxy)-4-((R)-3-hydroxy-5-phenylpentyl)hexahydro-2H-cyclopenta[b]furan-2-one |
| LATA-027 | 1240483-21-9 | (3aR,4R,5R,6aS)-5-((tert-butyldimethylsilyl)oxy)-4-((R)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpentyl)hexahydro-2H-cyclopenta[b]furan-2-one |
| LATA-028 | 1240483-22-0 | (3aR,4R,5R,6aS)-5-((tert-butyldimethylsilyl)oxy)-4-((R)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpentyl)hexahydro-2H-cyclopenta[b]furan-2-ol |
| LATA-029 | 1240483-23-1 | (Z)-7-((1R,2R,3R,5S)-3-((tert-butyldimethylsilyl)oxy)-2-((R)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpentyl)-5-hydroxycyclopentyl)hept-5-enoic acid |
| LATA-030 | 67-63-0 | propan-2-ol |
优化Route 4步骤 7 · 总收率 0.7 g
LATA-007145667-75-0LATA-00917814-85-6LATA-01041639-83-2LATA-01175-30-9LATA-03161263-22-7LATA-032856453-29-7LATA-033141074-03-5LATA-0341652582-57-4LATA-0351261926-71-9API · 拉坦前列素
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| LATA-007 | 145667-75-0 | (3aR,4R,5R,6aS)-5-hydroxy-4-((R)-3-hydroxy-5-phenylpentyl)hexahydro-2H-cyclopenta[b]furan-2-one |
| LATA-009 | 17814-85-6 | (4-carboxybutyl)triphenylphosphonium bromide |
| LATA-010 | 41639-83-2 | (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoic acid |
| LATA-011 | 75-30-9 | 2-iodopropane |
| LATA-031 | 61263-22-7 | (3aR,4R,5R,6aS)-4-((3R)-5-phenyl-3-((tetrahydro-2H-pyran-2-yl)oxy)pentyl)-5-((tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-cyclopenta[b]furan-2-one |
| LATA-032 | 856453-29-7 | (3aR,4R,5R,6aS)-4-((3R)-5-phenyl-3-((tetrahydro-2H-pyran-2-yl)oxy)pentyl)-5-((tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-cyclopenta[b]furan-2-ol |
| LATA-033 | 141074-03-5 | (Z)-7-((1R,2R,3R,5S)-5-hydroxy-2-((3R)-5-phenyl-3-((tetrahydro-2H-pyran-2-yl)oxy)pentyl)-3-((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)hept-5-enoic acid |
| LATA-034 | 1652582-57-4 | (8aR,9R,10R,11aS,Z)-9-((3R)-5-phenyl-3-((tetrahydro-2H-pyran-2-yl)oxy)pentyl)-10-((tetrahydro-2H-pyran-2-yl)oxy)-4,5,8,8a,9,10,11,11a-octahydrocyclopenta[b]oxecin-2(3H)-one |
| LATA-035 | 1261926-71-9 | (8aR,9R,10R,11aS,Z)-10-hydroxy-9-((R)-3-hydroxy-5-phenylpentyl)-4,5,8,8a,9,10,11,11a-octahydrocyclopenta[b]oxecin-2(3H)-one |
常见问题（FAQ）
拉坦前列素的适应症有哪些？
已批准的适应症包括：高眼压、开角型青光眼。
拉坦前列素的专利什么时候到期？
拉坦前列素的专利到期年暂无公开口径，本页会在数据管道核实后更新。
拉坦前列素有几条合成路线？
本站收录 4 条合成路线，最短路线 7 步、总收率 0.7 g。每条路线的中间体均带登记编号与 CAS 号。
拉坦前列素的关键中间体在哪里可以采购？
拉坦前列素路线中的中间体均已建立 CAS 档案，可直接按 CAS 发起询价，需求会进入供应网络撮合池。
如何获取拉坦前列素中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-22