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咪康唑/甲硝唑/利多卡因
Tier C · 观察 / 贸易Miconazole/Metronidazole/Lidocaine
Exeltis
原研
2010
首批上市
-
到期年（公开口径）
无销量数据
峰值销售
化学药
类型
靶点：CYP51A1、Sodium channels
商品名：Neo-Penotran Forte L
适应症（已批准）：滴虫感染、念珠菌病、阴道炎
各地区研发/上市状态
美国
-
欧盟
-
中国
终止
2008-06-13
日本
-
生产该 API 的工厂13
口径：平台供应网络（富通询价明细 + 产品主档）中登记生产该品种的工厂（在产口径），按报价活跃度排序；快照不含成本与客户信息。
已收录 13 家在产工厂名单，登录后可见（工厂信息不对未登录访客展示）。
登录查看工厂名单 →合成路线与中间体5 routes
原研路线 × 0优化路线（非专利）× 3工艺路线 × 2
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
优化Route 3步骤 2 · 总收率 /
Lidocaine Hydrochloride-023—Lidocaine Hydrochloride-024—Lidocaine Hydrochloride-025—Lidocaine Hydrochloride-010—API · 咪康唑/甲硝唑/利多卡因
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Lidocaine Hydrochloride-023 | - | N-Formyldiethylamine |
| Lidocaine Hydrochloride-024 | - | N-Ethyl-N-[(tributylstannyl)methyl]ethanamine |
| Lidocaine Hydrochloride-025 | - | 2-Isocyanato-1,3-dimethylbenzene |
| Lidocaine Hydrochloride-010 | - | 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide |
优化Route 1步骤 6 · 总收率 8.5g(Metronidazole (Free))
Metronidazole hydrochloride-001107-22-2Metronidazole hydrochloride-00275-07-0Metronidazole hydrochloride-003693-98-1Metronidazole hydrochloride-004696-23-1Metronidazole hydrochloride-005107-07-3Metronidazole hydrochloride-00675-05-8Metronidazole hydrochloride-007—Metronidazole hydrochloride-00822483-09-6Metronidazole hydrochloride-009—API · 咪康唑/甲硝唑/利多卡因
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Metronidazole hydrochloride-001 | 107-22-2在售 | Glyoxal |
| Metronidazole hydrochloride-002 | 75-07-0 | Ethanal |
| Metronidazole hydrochloride-003 | 693-98-1 | 2-Methylglyoxaline |
| Metronidazole hydrochloride-004 | 696-23-1 | 2-Methyl-4(5)-nitroimidazole |
| Metronidazole hydrochloride-005 | 107-07-3 | Ethylene chlorohydrin |
| Metronidazole hydrochloride-006 | 75-05-8 | Ethyl nitrile |
| Metronidazole hydrochloride-007 | - | Methyl ethanimidoate hydrochloride |
| Metronidazole hydrochloride-008 | 22483-09-6 | 2,2-Dimethoxyethanamine |
| Metronidazole hydrochloride-009 | - | N-(2,2-Dimethoxyethyl)ethanimidamide |
优化Route 1步骤 1 · 总收率 34 g
MICO-00113692-14-3MICO-00294-99-5MICO-003288-32-4Miconazole Nitrate22916-47-8API · 咪康唑/甲硝唑/利多卡因
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| MICO-001 | 13692-14-3 | 2-chloro-1-(2,4-dichlorophenyl)ethan-1-ol |
| MICO-002 | 94-99-5 | 2,4-dichloro-1-(chloromethyl)benzene |
| MICO-003 | 288-32-4 | 1H-imidazole |
| Miconazole Nitrate | 22916-47-8 | 1-(2-((2,4-dichlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole |
工艺Route 1步骤 8 · 总收率 93.4kg(Lidocaine Hydrochloride (API))
Lidocaine Hydrochloride-001—Lidocaine Hydrochloride-002—Lidocaine Hydrochloride-003—Lidocaine Hydrochloride-004—Lidocaine Hydrochloride-005—Lidocaine Hydrochloride-006—Lidocaine Hydrochloride-007—Lidocaine Hydrochloride-008—Lidocaine Hydrochloride-009—Lidocaine Hydrochloride-010—Lidocaine Hydrochloride-011—Lidocaine Hydrochloride-01259858-41-2Lidocaine Hydrochloride-013—Lidocaine Hydrochloride-014—Lidocaine Hydrochloride-015—Lidocaine Hydrochloride-016—Lidocaine Hydrochloride-017—API · 咪康唑/甲硝唑/利多卡因
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Lidocaine Hydrochloride-001 | - | 1,3-Dimethyl-2-nitrobenzene |
| Lidocaine Hydrochloride-002 | - | 2-Amino-1,3-dimethylbenzene |
| Lidocaine Hydrochloride-003 | - | 2-Bromanylethanoic acid |
| Lidocaine Hydrochloride-004 | - | 2-Chloroacetic acid |
| Lidocaine Hydrochloride-005 | - | 2-Chloranylethanoyl chloride |
| Lidocaine Hydrochloride-006 | - | 2-Chloroacetic acid methyl ester |
| Lidocaine Hydrochloride-007 | - | 2-Bromo-N-(2,6-dimethylphenyl)acetamide |
| Lidocaine Hydrochloride-008 | - | 1-Chloroacetylamino-2,6-dimethylbenzene |
| Lidocaine Hydrochloride-009 | - | N-Ethylethanamine |
| Lidocaine Hydrochloride-010 | - | 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide |
| Lidocaine Hydrochloride-011 | - | 2-(Diethylamino)acetic acid |
| Lidocaine Hydrochloride-012 | 59858-41-2 | 2-(Diethylamino)acetyl chloride |
| Lidocaine Hydrochloride-013 | - | Methyl 2-(diethylamino)acetate |
| Lidocaine Hydrochloride-014 | - | 3-(2-Methoxyphenyl)-1H-pyrazole |
| Lidocaine Hydrochloride-015 | - | 2-(Chloromethyl)pyridine hydrochloride |
| Lidocaine Hydrochloride-016 | - | - |
| Lidocaine Hydrochloride-017 | - | Dichloridomanganese 2-[[3-(2-methoxyphenyl)-1H-pyrazol-1-yl]methyl]pyridine |
工艺Route 2步骤 2 · 总收率 441.0666g(Lidocaine (Free))
Lidocaine Hydrochloride-002—Lidocaine Hydrochloride-01844978-98-5Lidocaine Hydrochloride-01927794-54-3Lidocaine Hydrochloride-020134756-56-2Lidocaine Hydrochloride-0211546682-40-9Lidocaine Hydrochloride-010—Lidocaine Hydrochloride-009—Lidocaine Hydrochloride-022—API · 咪康唑/甲硝唑/利多卡因
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Lidocaine Hydrochloride-002 | - | 2-Amino-1,3-dimethylbenzene |
| Lidocaine Hydrochloride-018 | 44978-98-5 | N2,N2-Diethyl-N,N-dimethylglycinamide |
| Lidocaine Hydrochloride-019 | 27794-54-3 | N,N,N2,N2-Tetraethylglycinamide |
| Lidocaine Hydrochloride-020 | 134756-56-2 | N2,N2-Diethyl-N,N-dipropan-2-ylglycinamide |
| Lidocaine Hydrochloride-021 | 1546682-40-9 | N2,N2-Diethyl-N,N-dipropylglycinamide |
| Lidocaine Hydrochloride-010 | - | 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide |
| Lidocaine Hydrochloride-009 | - | N-Ethylethanamine |
| Lidocaine Hydrochloride-022 | - | N-(2,6-Dimethylphenyl)-2-hydroxyacetamide |
常见问题（FAQ）
咪康唑/甲硝唑/利多卡因的适应症有哪些？
已批准的适应症包括：滴虫感染、念珠菌病、阴道炎。
咪康唑/甲硝唑/利多卡因的专利什么时候到期？
咪康唑/甲硝唑/利多卡因的专利到期年暂无公开口径，本页会在数据管道核实后更新。
咪康唑/甲硝唑/利多卡因有几条合成路线？
本站收录 5 条合成路线，最短路线 1 步、总收率 34 g。每条路线的中间体均带登记编号与 CAS 号。
咪康唑/甲硝唑/利多卡因的关键中间体在哪里可以采购？
咪康唑/甲硝唑/利多卡因的多条路线中间体已挂接 CAS 档案，其中 1 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。
如何获取咪康唑/甲硝唑/利多卡因中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-22