苯磺酸氨氯地平/奥美沙坦酯

Tier C · 观察 / 贸易

Amlodipine Besylate/Olmesartan Medoxomil

韩美药品株式会社

原研

2007

首批上市

到期年（公开口径）

无销量数据

峰值销售

化学药

类型

靶点：AT1、VDCCs

商品名：Azor

适应症（已批准）：原发性高血压、高血压

各地区研发/上市状态

美国

批准上市

2007-09-26

欧盟

中国

批准上市

2018-07-12

日本

生产该 API 的工厂14

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合成路线与中间体5 routes

原研路线 × 1优化路线（非专利）× 4工艺路线 × 0

路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。

原研Route 1步骤 7 · 总收率 16.6 g

OLME-0011187-42-4OLME-00243083-12-1OLME-00351802-42-7OLME-004144689-94-1OLME-005144689-93-0OLME-006124750-51-2OLME-007144690-33-5OLME-0081114761-92-0OLME-00980841-78-7OLME-010144690-92-6API · 苯磺酸氨氯地平/奥美沙坦酯

编号	CAS 号	中间体名称
OLME-001	1187-42-4	(2R,3R,4R,5S)-2-((benzoyloxy)methyl)-5-bromotetrahydrofuran-3,4-diyl dibenzoate
OLME-002	43083-12-1	1,1,1-trimethoxybutane
OLME-003	51802-42-7	2-propyl-1H-imidazole-4,5-dicarbonitrile
OLME-004	144689-94-1	diethyl 2-propyl-1H-imidazole-4,5-dicarboxylate
OLME-005	144689-93-0	ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
OLME-006	124750-51-2	5-(4'-(bromomethyl)-[1,1'-biphenyl]-2-yl)-1-trityl-1H-tetrazole
OLME-007	144690-33-5	ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate
OLME-008	1114761-92-0	lithium 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate
OLME-009	80841-78-7	4-(chloromethyl)-5-methyl-1,3-dioxol-2-one
OLME-010	144690-92-6	(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate

优化Route 2步骤 5 · 总收率 /

OLME-004144689-94-1OLME-005144689-93-0OLME-00980841-78-7OLME-010144690-92-6OLME-011114772-54-2OLME-012144690-96-0OLME-013144689-24-7API · 苯磺酸氨氯地平/奥美沙坦酯

编号	CAS 号	中间体名称
OLME-004	144689-94-1	diethyl 2-propyl-1H-imidazole-4,5-dicarboxylate
OLME-005	144689-93-0	ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
OLME-009	80841-78-7	4-(chloromethyl)-5-methyl-1,3-dioxol-2-one
OLME-010	144690-92-6	(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate
OLME-011	114772-54-2	4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile
OLME-012	144690-96-0	ethyl 1-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
OLME-013	144689-24-7	1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid

优化Route 3步骤 3 · 总收率 /

OLME-005144689-93-0OLME-006124750-51-2OLME-00980841-78-7OLME-010144690-92-6OLME-014144690-04-0OLME-015—API · 苯磺酸氨氯地平/奥美沙坦酯

编号	CAS 号	中间体名称
OLME-005	144689-93-0	ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
OLME-006	124750-51-2	5-(4'-(bromomethyl)-[1,1'-biphenyl]-2-yl)-1-trityl-1H-tetrazole
OLME-009	80841-78-7	4-(chloromethyl)-5-methyl-1,3-dioxol-2-one
OLME-010	144690-92-6	(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate
OLME-014	144690-04-0	4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid
OLME-015	-	(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

优化Route 4步骤 5 · 总收率 40 mg

OLME-005144689-93-0OLME-00980841-78-7OLME-016589-15-1OLME-017685091-51-4OLME-018—OLME-019—OLME-020—OLME-021—API · 苯磺酸氨氯地平/奥美沙坦酯

编号	CAS 号	中间体名称
OLME-005	144689-93-0	ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
OLME-009	80841-78-7	4-(chloromethyl)-5-methyl-1,3-dioxol-2-one
OLME-016	589-15-1	1-bromo-4-(bromomethyl)benzene
OLME-017	685091-51-4	ethyl 1-(4-bromobenzyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
OLME-018	-	(2-(1-(2-phenylpropan-2-yl)-1H-tetrazol-5-yl)phenyl)boronic acid
OLME-019	-	ethyl 4-(2-hydroxypropan-2-yl)-1-((2'-(1-(2-phenylpropan-2-yl)-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-propyl-1H-imidazole-5-carboxylate
OLME-020	-	4-(2-hydroxypropan-2-yl)-1-((2'-(1-(2-phenylpropan-2-yl)-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-propyl-1H-imidazole-5-carboxylic acid
OLME-021	-	(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-1-((2'-(1-(2-phenylpropan-2-yl)-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-propyl-1H-imidazole-5-carboxylate

优化Route 5步骤 5 · 总收率 /

OLME-00980841-78-7OLME-011114772-54-2OLME-022—OLME-023—OLME-0241309566-95-7OLME-0251199807-52-7OLME-0261993494-83-9API · 苯磺酸氨氯地平/奥美沙坦酯

编号	CAS 号	中间体名称
OLME-009	80841-78-7	4-(chloromethyl)-5-methyl-1,3-dioxol-2-one
OLME-011	114772-54-2	4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile
OLME-022	-	4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carbonitrile
OLME-023	-	4,4-dimethyl-2-propyl-4,6-dihydro-1H-furo[3,4-d]imidazol-6-ol
OLME-024	1309566-95-7	4'-((6-hydroxy-4,4-dimethyl-2-propyl-4,6-dihydro-1H-furo[3,4-d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile
OLME-025	1199807-52-7	1-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid
OLME-026	1993494-83-9	(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

常见问题（FAQ）

苯磺酸氨氯地平/奥美沙坦酯的适应症有哪些？

已批准的适应症包括：原发性高血压、高血压。

苯磺酸氨氯地平/奥美沙坦酯的专利什么时候到期？

苯磺酸氨氯地平/奥美沙坦酯的专利到期年暂无公开口径，本页会在数据管道核实后更新。

苯磺酸氨氯地平/奥美沙坦酯有几条合成路线？

本站收录 5 条合成路线，最短路线 3 步、总收率 /。每条路线的中间体均带登记编号与 CAS 号。

苯磺酸氨氯地平/奥美沙坦酯的关键中间体在哪里可以采购？

苯磺酸氨氯地平/奥美沙坦酯路线中的中间体均已建立 CAS 档案，可直接按 CAS 发起询价，需求会进入供应网络撮合池。

如何获取苯磺酸氨氯地平/奥美沙坦酯中间体的报价？

在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。

数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-22