← 返回专利悬崖列表
布地奈德/富马酸福莫特/格隆溴铵
Tier B · 提前布局Budesonide/Formoterol fumarate/Glycopyrronium Bromide
阿斯利康
原研
2019
首批上市
-
到期年（公开口径）
$1.2B ▲
峰值销售
化学药
类型
靶点：mAChRs、ADRB2、GR
商品名：Breztri Aerosphere、Breztri、Trixeo Aerosphere
适应症（已批准）：哮喘、慢性阻塞性肺疾病
各地区研发/上市状态
美国
批准上市
2020-07-23
欧盟
批准上市
2020-12-09
中国
批准上市
2019-12-18
日本
批准上市
2019-06-18
生产该 API 的工厂12
口径：平台供应网络（富通询价明细 + 产品主档）中登记生产该品种的工厂（在产口径），按报价活跃度排序；快照不含成本与客户信息。
已收录 12 家在产工厂名单，登录后可见（工厂信息不对未登录访客展示）。
登录查看工厂名单 →合成路线与中间体13 routes
原研路线 × 2优化路线（非专利）× 11工艺路线 × 0
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
原研Route 1步骤 5 · 总收率 /
Budesonide51333-22-3Budesonide-00137413-91-5Budesonide-00277017-20-0Budesonide-00391160-89-3Budesonide-00486401-80-1Budesonide-00513951-70-7Budesonide-006123-72-8API · 布地奈德/富马酸福莫特/格隆溴铵
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Budesonide | 51333-22-3 | - |
| Budesonide-001 | 37413-91-5 | 2-((8S,10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate |
| Budesonide-002 | 77017-20-0 | 2-((8S,10S,13S,14S,16R,17S)-16,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate |
| Budesonide-003 | 91160-89-3 | 2-((8S,9R,10S,11S,13S,14S,16R,17S)-9-bromo-11,16,17-trihydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate |
| Budesonide-004 | 86401-80-1 | 2-oxo-2-((8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)ethyl acetate |
| Budesonide-005 | 13951-70-7 | (8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one |
| Budesonide-006 | 123-72-8 | butyraldehyde |
原研Route 1步骤 4 · 总收率 22.7 g
GLYC-00115206-55-0GLYC-002137-43-9GLYC-00319833-96-6GLYC-004427-49-6GLYC-00513220-33-2GLYC-00613118-11-1API · 布地奈德/富马酸福莫特/格隆溴铵
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| GLYC-001 | 15206-55-0 | methyl 2-oxo-2-phenylacetate |
| GLYC-002 | 137-43-9 | bromocyclopentane |
| GLYC-003 | 19833-96-6 | methyl 2-cyclopentyl-2-hydroxy-2-phenylacetate |
| GLYC-004 | 427-49-6 | 2-cyclopentyl-2-hydroxy-2-phenylacetic acid |
| GLYC-005 | 13220-33-2 | 1-methylpyrrolidin-3-ol |
| GLYC-006 | 13118-11-1 | 1-methylpyrrolidin-3-yl 2-cyclopentyl-2-hydroxy-2-phenylacetate |
优化Route 1步骤 8 · 总收率 500mg(Formoterol Fumarate (API))
Formoterol Fumarate-001—Formoterol Fumarate-002—Formoterol Fumarate-003—Formoterol Fumarate-004—Formoterol Fumarate-0051199228-78-8Formoterol Fumarate-006—Formoterol Fumarate-007—Formoterol Fumarate-008—Formoterol Fumarate-009—Formoterol Fumarate-010—Formoterol Fumarate-011—Formoterol Fumarate-012—API · 布地奈德/富马酸福莫特/格隆溴铵
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Formoterol Fumarate-001 | - | 1-(4-Hydroxy-3-nitrophenyl)ethan-1-one |
| Formoterol Fumarate-002 | - | 1-(4-(Benzyloxy)-3-nitrophenyl)ethanone |
| Formoterol Fumarate-003 | - | 1-(4-(Benzyloxy)-3-nitrophenyl)-2-bromoethanone |
| Formoterol Fumarate-004 | - | (2R*)-N-Benzyl-1-(4-methoxyphenyl)propan-2-amine |
| Formoterol Fumarate-005 | 1199228-78-8 | (2R)-N-Benzyl-1-(4-methoxyphenyl)propan-2-amine hydrogen chloride |
| Formoterol Fumarate-006 | - | 2-[Benzyl[(2R*)-1-(4-methoxyphenyl)propan-2-yl]amino]-1-[4-(benzyloxy)-3-nitrophenyl]ethanone |
| Formoterol Fumarate-007 | - | (1R*)-2-[Benzyl[(2R*)-1-(4-methoxyphenyl)propan-2-yl]amino]-1-[4-(benzyloxy)-3-nitrophenyl]ethanol |
| Formoterol Fumarate-008 | - | (1R*)-1-[3-Amino-4-(benzyloxy)phenyl]-2-[benzyl[(2R*)-1-(4-methoxyphenyl)propan-2-yl]amino]ethanol |
| Formoterol Fumarate-009 | - | Acido formico |
| Formoterol Fumarate-010 | - | Amide c1 |
| Formoterol Fumarate-011 | - | N-[5-[(1R*)-2-[Benzyl[(2R*)-1-(4-methoxyphenyl)propan-2-yl]amino]-1-hydroxyethyl]-2-(benzyloxy)phenyl]formamide |
| Formoterol Fumarate-012 | - | N-[2-Hydroxy-5-[1(R*)-hydroxy-2-[1(R*)-methyl-2-(4-methoxyphenyl)ethylamino]ethyl]phenyl]formamide |
优化Route 2步骤 1 · 总收率 /
Formoterol Fumarate-013960303-94-0Formoterol Fumarate-014—Formoterol Fumarate-015—API · 布地奈德/富马酸福莫特/格隆溴铵
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Formoterol Fumarate-013 | 960303-94-0 | N-{5-[(1R)-2-amino-1-hydroxyethyl]-2-hydroxyphenyl}formamide |
| Formoterol Fumarate-014 | - | 1-(4-Methoxyphenyl)-2-propanone |
| Formoterol Fumarate-015 | - | 1,2-Ethylenedicarboxylic acid |
优化Route 3步骤 1 · 总收率 150mg(Formoterol Fumarate-017)
Formoterol Fumarate-016345288-55-3Formoterol Fumarate-017126587-93-7API · 布地奈德/富马酸福莫特/格隆溴铵
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Formoterol Fumarate-016 | 345288-55-3 | 1-[4-(Benzyloxy)-3-nitrophenyl]-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethanol |
| Formoterol Fumarate-017 | 126587-93-7 | N-[2-(Benzyloxy)-5-[1-hydroxy-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethyl]phenyl]formamide |
优化Route 4步骤 8 · 总收率 3.84g(Formoterol Fumarate (API))
Formoterol Fumarate-01843229-66-9Formoterol Fumarate-01943229-67-0Formoterol Fumarate-020—Formoterol Fumarate-021—Formoterol Fumarate-008—Formoterol Fumarate-007—Formoterol Fumarate-009—Formoterol Fumarate-011—Formoterol Fumarate-012—API · 布地奈德/富马酸福莫特/格隆溴铵
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Formoterol Fumarate-018 | 43229-66-9 | 2-[Benzyl[1-(4-methoxyphenyl)propan-2-yl]amino]-1-[4-(benzyloxy)-3-nitrophenyl]ethanone |
| Formoterol Fumarate-019 | 43229-67-0 | 2-[Benzyl[1-(4-methoxyphenyl)propan-2-yl]amino]-1-[4-(benzyloxy)-3-nitrophenyl]ethanol |
| Formoterol Fumarate-020 | - | 1-(4-Methoxyphenyl)-2-benzylaminopropane |
| Formoterol Fumarate-021 | - | 2-[4-(Benzyloxy)-3-nitrophenyl]oxirane |
| Formoterol Fumarate-008 | - | (1R*)-1-[3-Amino-4-(benzyloxy)phenyl]-2-[benzyl[(2R*)-1-(4-methoxyphenyl)propan-2-yl]amino]ethanol |
| Formoterol Fumarate-007 | - | (1R*)-2-[Benzyl[(2R*)-1-(4-methoxyphenyl)propan-2-yl]amino]-1-[4-(benzyloxy)-3-nitrophenyl]ethanol |
| Formoterol Fumarate-009 | - | Acido formico |
| Formoterol Fumarate-011 | - | N-[5-[(1R*)-2-[Benzyl[(2R*)-1-(4-methoxyphenyl)propan-2-yl]amino]-1-hydroxyethyl]-2-(benzyloxy)phenyl]formamide |
| Formoterol Fumarate-012 | - | N-[2-Hydroxy-5-[1(R*)-hydroxy-2-[1(R*)-methyl-2-(4-methoxyphenyl)ethylamino]ethyl]phenyl]formamide |
优化Route 5步骤 3 · 总收率 /
Formoterol Fumarate-022—Formoterol Fumarate-023—Formoterol Fumarate-024—Formoterol Fumarate-025—API · 布地奈德/富马酸福莫特/格隆溴铵
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Formoterol Fumarate-022 | - | - |
| Formoterol Fumarate-023 | - | - |
| Formoterol Fumarate-024 | - | - |
| Formoterol Fumarate-025 | - | - |
优化Route 6步骤 1 · 总收率 /
Formoterol Fumarate-026—Formoterol Fumarate-027—API · 布地奈德/富马酸福莫特/格隆溴铵
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Formoterol Fumarate-026 | - | Anisole |
| Formoterol Fumarate-027 | - | 1-Chloro-4-methoxybenzene |
优化Route 2步骤 3 · 总收率 361 g
GLYC-004427-49-6GLYC-00513220-33-2GLYC-0073140-73-6GLYC-0081392109-02-2GLYC-00613118-11-1API · 布地奈德/富马酸福莫特/格隆溴铵
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| GLYC-004 | 427-49-6 | 2-cyclopentyl-2-hydroxy-2-phenylacetic acid |
| GLYC-005 | 13220-33-2 | 1-methylpyrrolidin-3-ol |
| GLYC-007 | 3140-73-6 | 2-chloro-4,6-dimethoxy-1,3,5-triazine |
| GLYC-008 | 1392109-02-2 | 4,6-dimethoxy-1,3,5-triazin-2-yl 2-cyclopentyl-2-hydroxy-2-phenylacetate |
| GLYC-006 | 13118-11-1 | 1-methylpyrrolidin-3-yl 2-cyclopentyl-2-hydroxy-2-phenylacetate |
优化Route 3步骤 5 · 总收率 1.6 g
GLYC-002137-43-9GLYC-00917199-29-0GLYC-01081036-97-7GLYC-011937179-77-6GLYC-01264471-43-8GLYC-013860644-54-8GLYC-014104641-60-3GLYC-015937179-78-7API · 布地奈德/富马酸福莫特/格隆溴铵
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| GLYC-002 | 137-43-9 | bromocyclopentane |
| GLYC-009 | 17199-29-0在售 | (S)-2-hydroxy-2-phenylacetic acid |
| GLYC-010 | 81036-97-7 | (2S,5S)-2-(tert-butyl)-5-phenyl-1,3-dioxolan-4-one |
| GLYC-011 | 937179-77-6 | (2S,5S)-2-(tert-butyl)-5-cyclopentyl-5-phenyl-1,3-dioxolan-4-one |
| GLYC-012 | 64471-43-8 | (S)-2-cyclopentyl-2-hydroxy-2-phenylacetic acid |
| GLYC-013 | 860644-54-8 | methyl (S)-2-cyclopentyl-2-hydroxy-2-phenylacetate |
| GLYC-014 | 104641-60-3 | (R)-1-methylpyrrolidin-3-ol |
| GLYC-015 | 937179-78-7 | (R)-1-methylpyrrolidin-3-yl (S)-2-cyclopentyl-2-hydroxy-2-phenylacetate |
优化Route 4步骤 3 · 总收率 /
GLYC-00513220-33-2GLYC-00613118-11-1GLYC-0165763-56-4GLYC-0172243594-57-0GLYC-018108-86-1API · 布地奈德/富马酸福莫特/格隆溴铵
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| GLYC-005 | 13220-33-2 | 1-methylpyrrolidin-3-ol |
| GLYC-006 | 13118-11-1 | 1-methylpyrrolidin-3-yl 2-cyclopentyl-2-hydroxy-2-phenylacetate |
| GLYC-016 | 5763-56-4 | 2-cyclopentyl-2-oxoacetic acid |
| GLYC-017 | 2243594-57-0 | 1-methylpyrrolidin-3-yl 2-cyclopentyl-2-oxoacetate |
| GLYC-018 | 108-86-1 | bromobenzene |
优化Route 5步骤 4 · 总收率 144 g (Glycopyrronium Bromide)
GLYC-004427-49-6GLYC-00513220-33-2GLYC-00613118-11-1GLYC-019106650-00-4GLYC-0202220140-66-7API · 布地奈德/富马酸福莫特/格隆溴铵
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| GLYC-004 | 427-49-6 | 2-cyclopentyl-2-hydroxy-2-phenylacetic acid |
| GLYC-005 | 13220-33-2 | 1-methylpyrrolidin-3-ol |
| GLYC-006 | 13118-11-1 | 1-methylpyrrolidin-3-yl 2-cyclopentyl-2-hydroxy-2-phenylacetate |
| GLYC-019 | 106650-00-4 | 2-(benzyloxy)-2-cyclopentyl-2-phenylacetic acid |
| GLYC-020 | 2220140-66-7 | 1-methylpyrrolidin-3-yl 2-(benzyloxy)-2-cyclopentyl-2-phenylacetate |
优化Route 6步骤 4 · 总收率 3.9 g (Glycopyrronium Bromide)
GLYC-002137-43-9GLYC-00319833-96-6GLYC-004427-49-6GLYC-00513220-33-2GLYC-00613118-11-1GLYC-022611-73-4API · 布地奈德/富马酸福莫特/格隆溴铵
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| GLYC-002 | 137-43-9 | bromocyclopentane |
| GLYC-003 | 19833-96-6 | methyl 2-cyclopentyl-2-hydroxy-2-phenylacetate |
| GLYC-004 | 427-49-6 | 2-cyclopentyl-2-hydroxy-2-phenylacetic acid |
| GLYC-005 | 13220-33-2 | 1-methylpyrrolidin-3-ol |
| GLYC-006 | 13118-11-1 | 1-methylpyrrolidin-3-yl 2-cyclopentyl-2-hydroxy-2-phenylacetate |
| GLYC-022 | 611-73-4 | 2-oxo-2-phenylacetic acid |
常见问题（FAQ）
布地奈德/富马酸福莫特/格隆溴铵的适应症有哪些？
已批准的适应症包括：哮喘、慢性阻塞性肺疾病。
布地奈德/富马酸福莫特/格隆溴铵的专利什么时候到期？
布地奈德/富马酸福莫特/格隆溴铵的专利到期年暂无公开口径，本页会在数据管道核实后更新。
布地奈德/富马酸福莫特/格隆溴铵有几条合成路线？
本站收录 13 条合成路线，最短路线 1 步、总收率 /。每条路线的中间体均带登记编号与 CAS 号。
布地奈德/富马酸福莫特/格隆溴铵的关键中间体在哪里可以采购？
布地奈德/富马酸福莫特/格隆溴铵的多条路线中间体已挂接 CAS 档案，其中 1 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。
如何获取布地奈德/富马酸福莫特/格隆溴铵中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-22