← 返回专利悬崖列表
CAS 102029-44-7
(R)-4-(Phenylmethyl)-2-oxazolidinone(R)-4-benzyloxazolidin-2-one
登记编号：(I)638294-21-a、MITI-015、IPAT-002、RIMI-003
应用背景（按来源药适应症）
收缩性心力衰竭非奈利酮舒张期心力衰竭非奈利酮心脏衰竭非奈利酮慢性肾功能不全非奈利酮糖尿病肾病非奈利酮二型糖尿病非奈利酮二型糖尿病米格列奈钙糖尿病米格列奈钙乳腺癌帕他色替三阴性乳腺癌帕他色替去势抵抗性前列腺肿瘤帕他色替前列腺癌帕他色替腹膜癌帕他色替卵巢癌帕他色替大B细胞淋巴瘤Rimiducid霍奇金病Rimiducid非霍奇金淋巴瘤Rimiducid骨硬化症Rimiducid血红蛋白病Rimiducid血细胞减少症Rimiducid
来源药（使用该中间体的合成路线）
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(R)-4-(Phenylmethyl)-2-oxazolidinone→3-Hydroxy 3-butenoic acid beta-lactone→1-[(4R)-4-Benzyl-2-oxo-1,3-oxazolidin-3-yl]butane-1,3-dione→2-Methoxy-4-cyanobenzaldehyde→4-[2-[(4R)-4-Benzyl-2-oxo-1,3-oxazolidine-3-carbonyl]-3-oxobut-1-en-1-yl]-3-methoxybenzonitrile→4-Amino-5-methylpyridin-2(1H)-one→4-[3-[(4R)-4-Benzyl-2-oxo-1,3-oxazolidine-3-carbonyl]-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridin-4-yl]-3-methoxybenzonitrile→4-[(4S)-3-[(4R)-4-Benzyl-2-oxo-1,3-oxazolidine-3-carbonyl]-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridin-4-yl]-3-methoxybenzonitrile→1,1,1-Triethoxyethane→4-[(4S)-3-[(4R)-4-Benzyl-2-oxo-1,3-oxazolidine-3-carbonyl]-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-4-yl]-3-methoxybenzonitrile
(3aR,7aS)-octahydro-1H-isoindole→(S)-2-benzyl-4-((3aR,7aS)-octahydro-2H-isoindol-2-yl)-4-oxobutanoic acid→3-phenylpropanoic acid→(R)-4-benzyloxazolidin-2-one→(R)-4-benzyl-3-(3-phenylpropanoyl)oxazolidin-2-one→tert-butyl 2-bromoacetate→tert-butyl (S)-3-benzyl-4-((R)-4-benzyl-2-oxooxazolidin-3-yl)-4-oxobutanoate→(S)-3-benzyl-4-((R)-4-benzyl-2-oxooxazolidin-3-yl)-4-oxobutanoic acid→(S)-2-benzyl-1-((R)-4-benzyl-2-oxooxazolidin-3-yl)-4-((3aR,7aS)-octahydro-2H-isoindol-2-yl)butane-1,4-dione
2-(4-chlorophenyl)acetyl chloride→(R)-4-benzyloxazolidin-2-one→(R)-4-benzyl-3-(2-(4-chlorophenyl)acetyl)oxazolidin-2-one→tert-butyl isopropyl(methoxymethyl)carbamate→tert-butyl ((S)-3-((R)-4-benzyl-2-oxooxazolidin-3-yl)-2-(4-chlorophenyl)-3-oxopropyl)(isopropyl)carbamate→(S)-3-((tert-butoxycarbonyl)(isopropyl)amino)-2-(4-chlorophenyl)propanoic acid→(5R,7R)-5-methyl-4-(piperazin-1-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-7-ol dihydrochloride→tert-butyl ((S)-2-(4-chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)(isopropyl)carbamate→(S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one dihydrochloride
2-(3,4,5-trimethoxyphenyl)acetic acid→2-(3,4,5-trimethoxyphenyl)butanoic acid→(R)-4-benzyloxazolidin-2-one→(4R)-4-benzyl-3-(2-(3,4,5-trimethoxyphenyl)butanoyl)oxazolidin-2-one→(S)-2-(3,4,5-trimethoxyphenyl)butanoic acid→methyl (S)-piperidine-2-carboxylate→(S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylic acid→tert-butyl (R)-2-(3-(3-(3,4-dimethoxyphenyl)-1-hydroxypropyl)phenoxy)acetate→(R)-1-(3-(2-(tert-butoxy)-2-oxoethoxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate→3,4-dimethoxybenzaldehyde→1-(3-hydroxyphenyl)ethan-1-one→(E)-3-(3,4-dimethoxyphenyl)-1-(3-hydroxyphenyl)prop-2-en-1-one→3-(3,4-dimethoxyphenyl)-1-(3-hydroxyphenyl)propan-1-one→tert-butyl 2-(3-(3-(3,4-dimethoxyphenyl)propanoyl)phenoxy)acetate
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | (R)-4-Benzyl-2-oxazolidinone Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。