[(Ethenyl)oxy]ethane（CAS 109-92-2）中间体

应用背景（按来源药适应症）

乳腺癌Paclitaxel/Encequidar mesylate腺癌Paclitaxel/Encequidar mesylate血管肉瘤Paclitaxel/Encequidar mesylate实体瘤Paclitaxel/Encequidar mesylate避孕屈螺酮口腔炎，口疮屈螺酮经前焦虑性障碍屈螺酮经前期综合征屈螺酮痛经屈螺酮抑郁屈螺酮胰腺癌紫杉醇非小细胞肺癌紫杉醇霍奇金病紫杉醇精原细胞瘤紫杉醇卵巢癌紫杉醇乳腺癌紫杉醇Sjtoegren综合征西维美林口腔干燥西维美林辐射损伤西维美林口腔疾病西维美林头颈癌西维美林

来源药（使用该中间体的合成路线）

品种	梯队	到期年
Paclitaxel/Encequidar mesylate	Tier C · 观察 / 贸易	-
屈螺酮Drospirenone	Tier C · 观察 / 贸易	-
紫杉醇Paclitaxel	Tier B · 提前布局	-
西维美林Cevimeline Hydrochloride Hydrate	Tier C · 观察 / 贸易	-

合成路线中的位置（上下游链）

按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。

Paclitaxel/Encequidar mesylate优化路线步数：9总收率：/

(NZ)-4-Methoxy-N-(phenylmethylidene)aniline→(2-Chloranyl-2-oxidanylideneethyl) ethanoate→cis-1-(4-Methoxyphenyl)-2-oxo-4-phenylazetidin-3-yl acetate→cis-2-Oxo-4-phenylazetidin-3-yl acetate→alpha-Chlorobenzaldehyde→(3R,4S)-3-hydroxy-4-phenylazetidin-2-one→[(Ethenyl)oxy]ethane→(3R,4S)-3-(1-Ethoxyethoxy)-4-phenylazetidin-2-one→1-Benzoyl-3(R)-(1-ethoxyethoxy)-4(S)-phenylazetidin-2-one→3(S)-(Benzamido)-2(R)-(1-ethoxyethoxy)-3-phenylpropionic acid→(4S,5R)-5-(1-ethoxyethoxy)-2,4-diphenyl-5,6-dihydro-4H-1,3-oxazin-6-one→(2alpha,5beta,7beta,10beta,13alpha)-4-(Acetyloxy)-1,7,10,13-tetrahydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate→(1S,2S,3R,4S,7R,9R,10S,12R,15S)-4,12-bis(acetyloxy)-1,15-dihydroxy-10,14,17,17-tetramethyl-11-oxo-9-[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate

屈螺酮优化路线步数：5总收率：/

(1aR,1bR,5aR,5bS,7aS,8aS,9aS,9bS,9cR,9dR)-1b,3-Dihydroxy-5a,7a-dimethylperhydrocyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthren-8-one→[(Ethenyl)oxy]ethane→(1aR,5aR,5bS,7aS,8aS,9aS,9bS,9cR,9dR)-3-(1-Ethoxyethoxy)-1b-hydroxy-5a,7a-dimethylperhydrocyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthren-8-one→3-[(1aR,1bR,5aR,5bS,7aS,8R,8aS,9aS,9bS,9cR,9dR)-3-(1-Ethoxyethoxy)-1b,8-dihydroxy-5a,7a-dimethyloperhydrocyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthren-8-yl]propanenitrile→3-(5beta,17alpha-Dihydroxy-3-oxo-6beta,7beta:15beta,16beta-dimethyleneandrostan-17-yl)propanenitrile

紫杉醇优化路线步数：9总收率：/

(NZ)-4-Methoxy-N-(phenylmethylidene)aniline→(2-Chloranyl-2-oxidanylideneethyl) ethanoate→cis-1-(4-Methoxyphenyl)-2-oxo-4-phenylazetidin-3-yl acetate→cis-2-Oxo-4-phenylazetidin-3-yl acetate→alpha-Chlorobenzaldehyde→(3R,4S)-3-hydroxy-4-phenylazetidin-2-one→[(Ethenyl)oxy]ethane→(3R,4S)-3-(1-Ethoxyethoxy)-4-phenylazetidin-2-one→1-Benzoyl-3(R)-(1-ethoxyethoxy)-4(S)-phenylazetidin-2-one→3(S)-(Benzamido)-2(R)-(1-ethoxyethoxy)-3-phenylpropionic acid→(4S,5R)-5-(1-ethoxyethoxy)-2,4-diphenyl-5,6-dihydro-4H-1,3-oxazin-6-one→(2alpha,5beta,7beta,10beta,13alpha)-4-(Acetyloxy)-1,7,10,13-tetrahydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate→(1S,2S,3R,4S,7R,9R,10S,12R,15S)-4,12-bis(acetyloxy)-1,15-dihydroxy-10,14,17,17-tetramethyl-11-oxo-9-[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate

西维美林优化路线步数：5总收率：6.70 g

4-azaspiro[bicyclo[2.2.2]octane-2,2'-oxirane]→quinuclidin-3-one hydrochloride→S-(1-ethoxyethyl) ethanethioate→3-(((1-ethoxyethyl)thio)methyl)quinuclidin-3-ol→3-(((1-ethoxyethyl)thio)methyl)quinuclidin-3-ol benzoate→ethanethioic S-acid→ethoxyethene

本站可供应的对应中间体

目录暂未收录该靶点的在售中间体 —— 可直接发起询价，需求会进入撮合池。