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CAS 110-89-4
HexahydropyridineAzacyclohexane
登记编号：Eperisone Hydrochloride-003、(IV)320339-3-a,(IV)320339-3-b、(XIV)471701-1-b
应用背景（按来源药适应症）
背痛双氯芬酸钠/盐酸乙哌立松肌痉挛盐酸乙哌立松背痛盐酸乙哌立松腰痛盐酸乙哌立松C型尼曼匹克病柠檬酸阿利罗莫包涵体肌炎柠檬酸阿利罗莫III 型戈谢病柠檬酸阿利罗莫I 型戈谢病柠檬酸阿利罗莫肌萎缩性侧索硬化柠檬酸阿利罗莫流感病毒感染Norketotifen变应性结膜炎Norketotifen过敏性鼻炎Norketotifen
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 双氯芬酸钠/盐酸乙哌立松Diclofenac Sodium/Eperisone Hydrochloride | Tier C · 观察 / 贸易 | - |
| 盐酸乙哌立松Eperisone Hydrochloride | Tier C · 观察 / 贸易 | - |
| 柠檬酸阿利罗莫Arimoclomol Citrate | Tier C · 观察 / 贸易 | - |
| Norketotifen | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
1-(4-ethylphenyl)propan-1-one→Piperidine hydrochloride→Hexahydropyridine→3-chloro-1-(4-ethylphenyl)-2-methylpropan-1-one→3-amino-1-(4-ethylphenyl)-2-methylpropan-1-one→1,5-Dibromopentane→Ethylbenzene→2-methyl-3-(piperidin-1-yl)propanoyl chloride→1-(4-ethylphenyl)-2-methylprop-2-en-1-one
1-(4-ethylphenyl)propan-1-one→Piperidine hydrochloride→Hexahydropyridine→3-chloro-1-(4-ethylphenyl)-2-methylpropan-1-one→3-amino-1-(4-ethylphenyl)-2-methylpropan-1-one→1,5-Dibromopentane→Ethylbenzene→2-methyl-3-(piperidin-1-yl)propanoyl chloride→1-(4-ethylphenyl)-2-methylprop-2-en-1-one
Benzophenone oxime→(R)-(-)-Glycidyl m-nitrobenzenesulfonate→N-[[(2R)-Oxiran-2-yl]methoxy]-1,1-diphenylmethanimine→Azacyclohexane→N-[(2R)-2-Hydroxy-3-(piperidin-1-yl)propoxy]-1-oxo-1lambda5-pyridine-3-carboximidoyl chloride→(2R)-1-[[(Diphenylmethylidene)amino]oxy]-3-(piperidin-1-yl)propan-2-ol→(2R)-1-(Aminooxy)-3-(piperidin-1-yl)propan-2-ol--hydrogen chloride (1/1)→3-cyano-1-oxidopyridin-1-ium→N'-[(2R)-2-Hydroxy-3-(piperidin-1-yl)propoxy]-1-oxo-1lambda5-pyridine-3-carboximidamide
(R)-(-)-Glycidyl m-nitrobenzenesulfonate→Azacyclohexane→N-[(2R)-2-Hydroxy-3-(piperidin-1-yl)propoxy]-1-oxo-1lambda5-pyridine-3-carboximidoyl chloride→N'-hydroxypyridine-3-carboximidamide→N'-[[(2R)-Oxiran-2-yl]methoxy]pyridine-3-carboximidamide→N'-[(2R)-2-Hydroxy-3-(piperidin-1-yl)propoxy]pyridine-3-carboximidamide→N-[(2R)-2-hydroxy-3-(piperidin-1-yl)propoxy]pyridine-3-carbonimidoyl chloride
8,9-Dibromo-6-thiatricyclo[8.4.0.0(3,7)]tetradeca-1(10),3(7),4,11,13-pentaen-2-one→1-Methylpiperidn-4-ylmagnesium chloride→4-(1-Methyl-4-piperidinylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one→6-thiatricyclo[8.4.0.0(3,7)]tetradeca-1(10),3(7),4,11,13-pentaen-2-one→8-bromo-6-thiatricyclo[8.4.0.0(3,7)]tetradeca-1(10),3(7),4,8,11,13-hexaen-2-one→8-bromo-2-(1-methylpiperidin-4-yl)-6-thiatricyclo[8.4.0.0(3,7)]tetradeca-1(10),3(7),4,8,11,13-hexaen-2-ol→4-{8-bromo-6-thiatricyclo[8.4.0.0(3,7)]tetradeca-1(10),3(7),4,8,11,13-hexaen-2-ylidene}-1-methylpiperidine→Azacyclohexane→1-Methyl-4-[9-(piperidin-1-yl)-6-thiatricyclo[8.4.0.0(3,7)]tetradeca-1(14),3(7),4,8,10,12-hexaen-2-ylidene]piperidine→1-methyl-4-[8-(piperidin-1-yl)-6-thiatricyclo[8.4.0.0(3,7)]tetradeca-1(10),3(7),4,8,11,13-hexaen-2-ylidene]piperidine→2-(1-Methylpiperidin-4-ylidene)-6-thiatricyclo[8.4.0.0(3,7)]tetradeca-1(14),3(7),4,10,12-pentaen-9-one
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