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CAS 1126-09-6
ethyl piperidine-4-carboxylate
登记编号：AVAT-009、DONE-001、BALI-022
应用背景（按来源药适应症）
血小板减少马来酸阿伐曲泊帕特发性血小板减少性紫癜马来酸阿伐曲泊帕肝脏疾病马来酸阿伐曲泊帕阿尔茨海默病盐酸美金刚/盐酸多奈哌齐荨麻疹比拉斯汀过敏性鼻炎比拉斯汀皮炎比拉斯汀瘙痒症比拉斯汀湿疹比拉斯汀变应性结膜炎比拉斯汀路易氏体型失智症盐酸多奈哌齐阿尔茨海默病盐酸多奈哌齐痴呆盐酸多奈哌齐记忆障碍盐酸多奈哌齐轻度认知障碍盐酸多奈哌齐骨质疏松症盐酸多奈哌齐
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 马来酸阿伐曲泊帕Avatrombopag Maleate | Tier C · 观察 / 贸易 | 2030 |
| 盐酸美金刚/盐酸多奈哌齐Memantine Hydrochloride/Donepezil Hydrochloride | Tier C · 观察 / 贸易 | - |
| 比拉斯汀Bilastine | Tier C · 观察 / 贸易 | - |
| 盐酸多奈哌齐Donepezil Hydrochloride | Tier B · 提前布局 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
1-(4-chlorothiophen-2-yl)ethanone→2-bromo-1-(4-chlorothiophen-2-yl)ethanone→thiourea→4-(4-chlorothiophen-2-yl)thiazol-2-amine→1-cyclohexylpiperazine→4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine→5,6-dichloronicotinic acid→5,6-dichloro-N-(4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)nicotinamide→ethyl piperidine-4-carboxylate→ethyl 1-(3-chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylate→maleic acid
2-(4-bromophenyl)ethan-1-ol→((1-ethoxy-2-methylprop-1-en-1-yl)oxy)trimethylsilane→ethyl 2-(4-(2-hydroxyethyl)phenyl)-2-methylpropanoate→4-bromophenethyl methanesulfonate→ethyl piperidine-4-carboxylate→ethyl 1-(2-(4-bromophenyl)-2-oxoethyl)piperidine-4-carboxylate fumarate→N1-(2-ethoxyethyl)benzene-1,2-diamine→2-(1-(4-bromophenethyl)piperidin-4-yl)-1-(2-ethoxyethyl)-1H-benzo[d]imidazole
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | 4-(4-chloro-2-thienyl)-2-ThiazolaMine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 1-Cyclohexylpiperazine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 5,6-Dichloronicotinic acid Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 2-Piperidin-4-yl-1H-benzoimidazole Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | tert-butyl 4-(1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 1-(2-Ethoxy-ethyl)-2-piperidin-4-yl-1H-benzimidazole Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 4-(2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)propan-2-yl)phenethyl 4-methylbenzenesulfonate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。