CAS 123-62-6

propionic anhydrideMethylacetic anhydride

登记编号：PARE-005、(IIc)471701-2-a、EMOX-002

应用背景（按来源药适应症）

术后疼痛帕瑞昔布钠神经疾病帕瑞昔布钠肩部疼痛帕瑞昔布钠流感病毒感染Norketotifen变应性结膜炎Norketotifen过敏性鼻炎Norketotifen缺血性卒中Ethylmethylhydroxypyridine Succinate开角型青光眼Ethylmethylhydroxypyridine Succinate焦虑症Ethylmethylhydroxypyridine Succinate注意力缺陷障碍伴多动Ethylmethylhydroxypyridine Succinate脑缺血Ethylmethylhydroxypyridine Succinate

来源药（使用该中间体的合成路线）

品种	梯队	到期年
帕瑞昔布钠Parecoxib Sodium	Tier C · 观察 / 贸易	-
Norketotifen	Tier C · 观察 / 贸易	-
Ethylmethylhydroxypyridine Succinate	Tier C · 观察 / 贸易	-

合成路线中的位置（上下游链）

按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。

帕瑞昔布钠原研路线步数：5总收率：12.2 g

1,2-diphenylethan-1-one→(E)-1,2-diphenylethan-1-one oxime→5-methyl-3,4-diphenyl-4,5-dihydroisoxazol-5-ol→4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide→propionic anhydride→N-((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)propionamide

帕瑞昔布钠优化路线步数：7总收率：9.11 g

1,2-diphenylethan-1-one→5-methyl-3,4-diphenyl-4,5-dihydroisoxazol-5-ol→4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide→propionic anhydride→N-((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)propionamide→(Z)-1-(1,2-diphenylvinyl)pyrrolidine→(Z)-3,4-diphenyl-4-(pyrrolidin-1-yl)but-3-en-2-one→5-methyl-3,4-diphenylisoxazole

帕瑞昔布钠优化路线步数：5总收率：11.9 g

1,2-diphenylethan-1-one→4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide→propionic anhydride→4-(2-oxo-2-phenylethyl)benzenesulfonic acid→4-(1,3-dioxo-1-phenylbutan-2-yl)benzenesulfonic acid→4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonic acid

Norketotifen优化路线步数：2总收率：/

4-(1-Methyl-4-piperidinylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one→Acetic acid acetic anhydride→Dicarbonic acid diethyl diester→Methylacetic anhydride→Benzoic acid anhydride→Dibenzyl dicarbonate→Butanoic acid 1-oxobutyl ester→4-(1-Acetylpiperidin-4-ylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one→4-[8-Oxo-6-thiatricyclo[8.4.0.0(3,7)]tetradeca-1(14),3(7),4,10,12-pentaen-2-ylidene]piperidine-1-carboxylic acid ethyl ester→4-(1-Propanoylpiperidin-4-ylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one→4-(1-Benzoylpiperidin-4-ylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one→Benzyl 4-(10-oxo-9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)piperidine-1-carboxylate→4-(1-Butanoylpiperidin-4-ylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one

Ethylmethylhydroxypyridine Succinate原研路线步数：2总收率：30 g

2-methylfuran→propionic anhydride→1-(5-methylfuran-2-yl)propan-1-one

本站可供应的对应中间体

同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。

供应商	产品	价格区间	最小起订	货期	资质	操作
Unibest Nantong cGMP Site	5-Methyl-3,4-diphenylisoxazole Pharmaceutical Intermediates	询价	询价	询价	—

本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。