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CAS 141699-59-4
tert-butyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate
登记编号：CRIT-017、LONA-019、SAPI-002
应用背景（按来源药适应症）
原发性皮肤间变性大细胞淋巴瘤克唑替尼间变大细胞淋巴瘤克唑替尼非小细胞肺癌克唑替尼神经鞘瘤克唑替尼神经纤维瘤病II型克唑替尼多发性骨髓瘤克唑替尼早衰综合征氯那法尼丁型肝炎氯那法尼幕上肿瘤氯那法尼神经胶质肉瘤氯那法尼慢性丁型肝炎氯那法尼非小细胞肺癌氯那法尼非小细胞肺癌Sapitinib转移性乳腺癌Sapitinib肿瘤Sapitinib乳腺癌Sapitinib食道癌Sapitinib胃癌Sapitinib
来源药（使用该中间体的合成路线）
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→tert-butyl (R)-4-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate→tert-butyl 4-hydroxypiperidine-1-carboxylate→tert-butyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate→4-iodo-1H-pyrazole→tert-butyl 4-(4-iodo-1H-pyrazol-1-yl)piperidine-1-carboxylate→tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate
2-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid→tert-butyl (R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxylate→(R)-1-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-(piperidin-4-yl)ethan-1-one→3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine→3-bromo-8-chloro-7-nitro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine→3-bromo-8-chloro-9-nitro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine→3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-7-amine→3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-9-amine→3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-7-amine→3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-9-amine→3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine→tert-butyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate→tert-butyl (R)-4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidine-1-carboxylate→tert-butyl (R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxylate acetyl-L-phenylalaninate
3-hydroxy-4-methoxybenzonitrile→tert-butyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate→tert-butyl 4-(5-cyano-2-methoxyphenoxy)piperidine-1-carboxylate→4-methoxy-3-(piperidin-4-yloxy)benzonitrile hydrochloride→2-(4-(5-cyano-2-methoxyphenoxy)piperidin-1-yl)-N-methylacetamide→2-(4-(5-cyano-2-methoxy-4-nitrophenoxy)piperidin-1-yl)-N-methylacetamide→2-(4-(4-amino-5-cyano-2-methoxyphenoxy)piperidin-1-yl)-N-methylacetamide→(E)-N,N'-bis(3-chloro-2-fluorophenyl)formimidamide→3-chloro-2-fluoroaniline→triethoxymethane→2-(4-((4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)-N-methylacetamide
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H- pyrazol-1-yl]piperidine-1-carboxylate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | [5-Bromo-3-[(1R)-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin -2- yl]amine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 2-amino-5-bromopyridin-3-ol Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。