CAS 269410-08-4

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

登记编号：RUXO-003

应用背景（按来源药适应症）

特应性皮炎磷酸芦可替尼白癜风磷酸芦可替尼移植物抗宿主病磷酸芦可替尼骨髓纤维化磷酸芦可替尼真性红细胞增多症磷酸芦可替尼

来源药（使用该中间体的合成路线）

品种	梯队	到期年
磷酸芦可替尼Ruxolitinib Phosphate	Tier A · 立即攻坚	2028

合成路线中的位置（上下游链）

按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。

磷酸芦可替尼原研路线步数：5总收率：171.7 mg

4-chloro-7H-pyrrolo[2,3-d]pyrimidine→4-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine→4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole→4-(1H-pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine→3-cyclopentylacrylonitrile→(R)-3-cyclopentyl-3-(4-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)propanenitrile

本站可供应的对应中间体

同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。

供应商	产品	价格区间	最小起订	货期	资质
Unibest Nantong cGMP Site	1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	-CYCLOPENTYLACRYLONITRILE Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	Cyclopentanecarbaldehyde Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	4-Chloropyrrolo[2,3-d]pyrimidine Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	4-(1H-pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	3-cyclopentyl-3-[4-(7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	(3R)-3-cyclopentyl-3-[4-(7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	(S)-3-cyclopentyl-3-hydrazinylpropanenitrile L-tartaric acid salt dihydrate Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	2-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)acetic acid Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	4-methyl-7H-pyrrolo[2,3-d]pyrimidine Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	(R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	(4-(1-(2-Cyano-1-cyclopentylethyl)-1h-pyrazol-4-yl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	4-CHLORO-7-((2-(TRIMETHYLSILYL)ETHOXY)METHYL)-7H-PYRROLO[2,3-D]PYRIMIDINE Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	1H-Pyrazole-1-propanamide, 4-bromo-β-cyclopentyl-, (βR)- Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	(R)-3-(4-broMo-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	(R)-3-cyclopentyl-3-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanenitrile Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	3-Cyclopentyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propanenitrile Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate Pharmaceutical Intermediates	询价	询价	询价	—

本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。