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CAS 27144-18-9
3-(Tritylsulfanyl)propanoic acidS-(Trityl)-mercapto propionic acid3-(tritylthio)propanoic acid
登记编号：Atosiban-021、EPTI-013
应用背景（按来源药适应症）
产科分娩（早产）阿托西班醋酸盐早产（孕37周前）阿托西班醋酸盐子宫内膜异位症阿托西班醋酸盐不稳定型心绞痛依替巴肽心肌梗塞依替巴肽缺血性卒中依替巴肽急性冠脉综合征依替巴肽镰状细胞血症依替巴肽ST段抬高型心肌梗死依替巴肽
来源药（使用该中间体的合成路线）
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
Resin bound N-[(2S,5S)-2-[(2S)-butan-2-yl]-5-(4-ethoxybenzyl)-4,7-dioxo-9-(tritylsulfanyl)nonanoyl]-O-tert-butyl-L-threonyl-N-trityl-L-asparaginyl-S-trityl-L-cysteinyl-L-prolyl-N5-(tert-butoxycarbonyl)-L-ornithylglycinamid→Resin bound N-[(2S,5R)-5-amino-2-[(2S)-butan-2-yl]-6-(4-ethoxyphenyl)-4-oxohexanoyl]-O-tert-butyl-L-threonyl-N-trityl-L-asparaginyl-S-trityl-L-cysteinyl-L-prolyl-N5-(tert-butoxycarbonyl)-L-ornithylglycinamide→3-(Tritylsulfanyl)propanoic acid→Resin bound 1-([(4R,7S,10S,13S,16S)-13-[(2S)-butan-2-yl]-10-[(1R)-1-tert-butoxyethyl]-16-(4-ethoxybenzyl)-6,9,12,15,18-pentaoxo-7-[2-oxo-2-(tritylamino)ethyl]-1,2-dithia-5,8,11-triazacycloicosan-4-yl]carbonyl)-L-prolyl-N5-(tert-butoxycarbonyl)-L-ornithylglycinamide→1-[(4R,7S,10S,13S,16S)-7-(2-Amino-2-oxoethyl)-13-[(2S)-butan-2-yl]-16-[(4-ethoxyphenyl)methyl]-10-[(1R)-1-hydroxyethyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11-triazacycloicosane-4-carbonyl]-L-prolyl-L-ornithylglycinamide<-fgf->1-(3-Mercaptopropanoic acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithineoxytocin<-fgf->1-Deamino-2-D-Tyr-(O-ethyl)-4-Thr-8-ornoxytocin
2,5-Dioxopyrrolidin-1-yl O-ethyl-N-[3-[(triphenylmethyl)sulfanyl]propanoyl]-D-tyrosyl-L-isoleucyl-O-tert-butyl-L-threoninate→1-([3-[(Triphenylmethyl)sulfanyl]propanoyl]oxy)pyrrolidine-2,5-dione→O-Ethyl-D-tyrosine hydrogen chloride→O-Ethyl-N-[3-[(triphenylmethyl)sulfanyl]propanoyl]-D-tyrosine→2,5-Dioxopyrrolidin-1-yl O-ethyl-N-[3-[(triphenylmethyl)sulfanyl]propanoyl]-D-tyrosinate→2(S)-Amino-3(S)-methylpentanoic acid→O-Ethyl-N-[3-[(triphenylmethyl)sulfanyl]propanoyl]-D-tyrosyl-L-isoleucine→2,5-Dioxopyrrolidin-1-yl O-ethyl-N-[3-[(triphenylmethyl)sulfanyl]propanoyl]-D-tyrosyl-L-isoleucinate→O-tert-Butyl-L-threonine→O-Ethyl-N-[3-[(triphenylmethyl)sulfanyl]propanoyl]-D-tyrosyl-L-isoleucyl-O-tert-butyl-L-threonine→3-(Tritylsulfanyl)propanoic acid
O-Ethyl-N-[3-[(triphenylmethyl)sulfanyl]propanoyl]-D-tyrosyl-L-isoleucyl-O-tert-butyl-L-threonyl-N-(triphenylmethyl)-L-asparaginyl-S-(acetamidomethyl)-L-cysteinyl-L-prolyl-N5-(tert-butoxycarbonyl)-L-ornithylglycine→CTC resin bound O-ethyl-N-[3-[(triphenylmethyl)sulfanyl]propanoyl]-D-tyrosyl-L-isoleucyl-O-tert-butyl-L-threonyl-N-(triphenylmethyl)-L-asparaginyl-S-(acetamidomethyl)-L-cysteinyl-L-prolyl-N5-(tert-butoxycarbonyl)-L-ornithylglycine→3-(Tritylsulfanyl)propanoic acid→CTC resin bound O-ethyl-D-tyrosyl-L-isoleucyl-O-tert-butyl-L-threonyl-N-(triphenylmethyl)-L-asparaginyl-S-(triphenylmethyl)-L-cysteinyl-L-prolyl-N5-(tert-butoxycarbonyl)-L-ornithylglycine
Methyl N-(tert-butoxycarbonyl)-L-isoleucyl-L-threoninate→L-Threonine→Methyl L-threoninate hydrogen chloride→Methyl L-isoleucyl-L-threoninate→N-(tert-Butoxycarbonyl)-O-ethyl-D-tyrosine→Methyl N-(tert-butoxycarbonyl)-O-ethyl-D-tyrosyl-L-isoleucyl-L-threoninate→Methyl O-ethyl-D-tyrosyl-L-isoleucyl-L-threoninate→Methyl O-ethyl-N-[3-[(triphenylmethyl)sulfanyl]propanoyl]-D-tyrosyl-L-isoleucyl-L-threoninate→O-Ethyl-N-[3-[(triphenylmethyl)sulfanyl]propanoyl]-D-tyrosyl-L-isoleucyl-L-threonine→S-(Trityl)-mercapto propionic acid→N-(tert-Butoxycarbonyl)-L-isoleucine
Resin bound O-ethyl-N-[3-[(triphenylmethyl)sulfanyl]propanoyl]-D-tyrosyl-L-isoleucyl-L-threonyl-L-asparaginyl-S-(triphenylmethyl)-L-cysteinyl-L-prolyl-L-ornithylglycinamide→Resin bound L-isoleucyl-L-threonyl-L-asparaginyl-S-(triphenylmethyl)-L-cysteinyl-L-prolyl-L-ornithylglycinamide→Resin bound O-ethyl-D-tyrosyl-L-isoleucyl-L-threonyl-L-asparaginyl-S-(triphenylmethyl)-L-cysteinyl-L-prolyl-L-ornithylglycinamide→S-(Trityl)-mercapto propionic acid→Resin bound L-threonyl-L-asparaginyl-S-(triphenylmethyl)-L-cysteinyl-L-prolyl-L-ornithylglycinamide→N-[[(9H-Fluoren-9-yl)methoxy]carbonyl]-L-isoleucine→O-Ethyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-tyrosine
本站可供应的对应中间体
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