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CAS 288-13-1
1,2-Diazole1H-pyrazole
登记编号：(XXIX)1024528-1-c、CRIT-021、PALOV-010、TASE-025、ITACI-018
应用背景（按来源药适应症）
非小细胞肺癌普拉替尼甲状腺瘤普拉替尼甲状腺髓样癌普拉替尼原发性皮肤间变性大细胞淋巴瘤克唑替尼间变大细胞淋巴瘤克唑替尼非小细胞肺癌克唑替尼神经鞘瘤克唑替尼神经纤维瘤病II型克唑替尼多发性骨髓瘤克唑替尼进行性肌肉骨化症Palovarotene肝功能衰退Palovarotene异位骨化Palovarotene遗传性多发性外生骨疣Palovarotene干眼综合征Palovarotene气肿Palovarotene乳腺癌Taselisib膀胱癌Taselisib多发性骨髓瘤Taselisib肺癌Taselisib肝癌Taselisib宫颈癌Taselisib弥漫性大B-细胞淋巴瘤Itacitinib骨髓增生性疾病Itacitinib急性淋巴细胞白血病Itacitinib急性髓细胞样白血病Itacitinib慢性骨髓单核细胞性白血病Itacitinib骨髓增生异常-骨髓增生性疾病Itacitinib
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 普拉替尼Pralsetinib | Tier C · 观察 / 贸易 | 2031 |
| 克唑替尼Crizotinib | Tier C · 观察 / 贸易 | - |
| Palovarotene | Tier C · 观察 / 贸易 | - |
| Taselisib | Tier C · 观察 / 贸易 | - |
| Itacitinib | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
1-[6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethan-1-one→4-Fluoro-1H-pyrazole→2,2,3,3-Tetrafluoropropan-1-ol→4-(2,2,3,3-Tetrafluoropropyl)morpholine→4-Methyl-4-(2,2,3,3-tetrafluoropropyl)morpholin-4-ium mesylate→1,2-Diazole→4-Methyl-4-[(1Z)-2,3,3-trifluoroprop-1-en-1-yl]morpholin-4-ium methanesulfonate→(2Z)-2-Fluoro-3-(morpholin-4-yl)prop-2-enal→Hydrazine dihydrochloride→4-Fluoro-1H-pyrazole hydrogen chloride→5-Bromo-2-chloropyridine→Acetic acid acetic anhydride→1-(6-Chloropyridin-3-yl)ethanone
2,5-dimethylhexane-2,5-diol→2,5-dichloro-2,5-dimethylhexane→1-bromo-2-methylbenzene→6-bromo-1,1,4,4,7-pentamethyl-1,2,3,4-tetrahydronaphthalene→3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalene-2-carbonitrile→3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalene-2-carbaldehyde→methyl 4-((dimethoxyphosphoryl)methyl)benzoate→(E)-methyl 4-(2-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoate→(E)-methyl 4-(2-(3-(bromomethyl)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoate→1H-pyrazole→(E)-methyl 4-(2-(3-((1H-pyrazol-1-yl)methyl)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoate
9-bromo-2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine→4-bromo-2-fluorobenzonitrile→4-bromo-2-fluoro-N-hydroxybenzimidamide→ethyl propiolate→ethyl 3-((4-bromo-2-fluorobenzimidamido)oxy)acrylate→ethyl 2-(4-bromo-2-fluorophenyl)-1H-imidazole-4-carboxylate→1,3-dioxolan-2-one→ethyl 2-(4-bromo-2-fluorophenyl)-1-(2-hydroxyethyl)-1H-imidazole-4-carboxylate→9-bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxylic acid→9-bromo-N-(1-iminoethyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide→ethyl 2-methyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanoate→ethyl 2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanoate→2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanoic acid→ethyl 2-bromo-2-methylpropanoate→1H-pyrazole→ethyl 2-methyl-2-(1H-pyrazol-1-yl)propanoate→2,5-dibromo-4,4-dimethylcyclopentane-1,3-dione→ethyl 2-(4-bromo-1H-pyrazol-1-yl)-2-methylpropanoate→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)
diphenylmethanamine→2-(chloromethyl)oxirane→1-benzhydrylazetidin-3-ol hydrochloride→tert-butyl 3-hydroxyazetidine-1-carboxylate→tert-butyl 3-oxoazetidine-1-carboxylate→diethyl (cyanomethyl)phosphonate→tert-butyl 3-(cyanomethylene)azetidine-1-carboxylate→4-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)-1H-pyrazole→tert-butyl 3-(cyanomethyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate→4-chloro-7H-pyrrolo[2,3-d]pyrimidine→tert-butyl 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-(cyanomethyl)azetidine-1-carboxylate→2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile dihydrochloride→1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl)piperidin-4-one→1,4-dioxa-8-azaspiro[4.5]decane hydrochloride→1,4-dioxa-8-azaspiro[4.5]decane→3-fluoro-2-(trifluoromethyl)isonicotinic acid→(3-fluoro-2-(trifluoromethyl)pyridin-4-yl)(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methanone→1H-pyrazole→4-iodo-1H-pyrazole→4-iodo-1-(trimethylsilyl)-1H-pyrazole→2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane→2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl)piperidin-4-yl)azetidin-3-yl)acetonitrile→2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl)piperidin-4-yl)azetidin-3-yl)acetonitrile adipate
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H- pyrazol-1-yl]piperidine-1-carboxylate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | [5-Bromo-3-[(1R)-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin -2- yl]amine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 2-amino-5-bromopyridin-3-ol Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。