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CAS 4746-97-8
1,4 Cyclohexanedione ethylene ketal1,4-dioxaspiro[4.5]decan-8-one1,4-Dioxaspiro[4.5]decan-8-one
登记编号：(I)1024528-1-a,(I)1024528-1-d、(XI)1024528-3-b、CEBR-001、DEXP-001
应用背景（按来源药适应症）
非小细胞肺癌普拉替尼甲状腺瘤普拉替尼甲状腺髓样癌普拉替尼疼痛Cebranopadol hemicitrate急性疼痛Cebranopadol hemicitrate神经痛Cebranopadol hemicitrate腰痛Cebranopadol hemicitrate物质相关性障碍Cebranopadol hemicitrate慢性疼痛Cebranopadol hemicitrate肺嗜酸粒细胞增多盐酸右旋普拉克索哮喘盐酸右旋普拉克索慢性阻塞性肺疾病盐酸右旋普拉克索高嗜酸性粒细胞综合征盐酸右旋普拉克索肌萎缩性侧索硬化盐酸右旋普拉克索嗜酸粒细胞性哮喘盐酸右旋普拉克索
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 普拉替尼Pralsetinib | Tier C · 观察 / 贸易 | 2031 |
| Cebranopadol hemicitrate | Tier C · 观察 / 贸易 | - |
| 盐酸右旋普拉克索Dexpramipexole Dihydrochloride | Tier C · 观察 / 贸易 | - |
| 氢溴酸依他佐辛Eptazocine hydrobromide | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
1,4 Cyclohexanedione ethylene ketal→Methyl 8-methoxy-1,4-dioxaspiro[4.5]decane-8-carboxylate→Methyl 1-methoxy-4-oxocyclohexane-1-carboxylate→Methyl 4-hydroxy-1-methoxycyclohexane-1-carboxylate→Methyl 4-iodo-1-methoxycyclohexane-1-carboxylate→2-Chloro-4-methyl-6-(methylsulfanyl)pyrimidine→2,4-Dichloro-6-methylpyrimidine→Methyl 1-methoxy-4-[4-methyl-6-(methylsulfanyl)pyrimidin-2-yl]cyclohexane-1-carboxylate→Methyl 4-[4-(methanesulfonyl)-6-methylpyrimidin-2-yl]-1-methoxycyclohexane-1-carboxylate→Methyl 1-methoxy-4-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)cyclohexane-1-carboxylate→Methyl 4-(4-chloro-6-methylpyrimidin-2-yl)-1-methoxycyclohexane-1-carboxylate
1,4 Cyclohexanedione ethylene ketal→Methyl 1-methoxy-4-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)cyclohexane-1-carboxylate→1,4-Dioxaspiro[4.5]decane-8-carbonitrile→N-Hydroxy-1,4-dioxaspiro[4.5]decane-8-carboximidamide→1,4-Dioxaspiro[4.5]decane-8-carboximidamide→1-Ethoxybutane-1,3-dione→2-(1,4-Dioxaspiro[4.5]decan-8-yl)-6-methylpyrimidin-4-ol→4-(4-Hydroxy-6-methylpyrimidin-2-yl)cyclohexan-1-one
Methyl 4-cyano-1-methoxycyclohexane-1-carboxylate→(1S)-1-[6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethan-1-amine hydrogen chloride→1,4 Cyclohexanedione ethylene ketal→Methyl 8-methoxy-1,4-dioxaspiro[4.5]decane-8-carboxylate→Methyl 1-methoxy-4-oxocyclohexane-1-carboxylate→1,4-Dioxaspiro[4.5]decane-8-carbonitrile→4-Oxocyclohexane-1-carbonitrile
1,4-dioxaspiro[4.5]decan-8-one→N-methyl-1,4-dioxaspiro[4.5]decan-8-imine→4-(methylamino)-4-phenylcyclohexan-1-one→4-(dimethylamino)-4-phenylcyclohexan-1-one→2-(5-fluoro-1H-indol-3-yl)ethan-1-ol→(1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indol]-4-amine→(4-fluorophenyl)hydrazine hydrochloride→2,3-dihydrofuran
1,4-dioxaspiro[4.5]decan-8-one→(1,4-dioxaspiro[4.5]dec-7-en-8-yloxy)trimethylsilane→5,7-dihydro-4H-spiro[benzo[d]thiazole-6,2'-[1,3]dioxolan]-2-amine→2-amino-4,5-dihydrobenzo[d]thiazol-6(7H)-one→N-(6-oxo-4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)acetamide→(R)-N-(6-hydroxy-4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)acetamide→(S)-2-acetamido-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl benzoate→(S)-N-(6-hydroxy-4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)acetamide→(S)-2-acetamido-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl 4-methylbenzenesulfonate→(R)-N-(6-azido-4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)acetamide→(R)-N-(6-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)acetamide→(R)-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine→propyl 4-methylbenzenesulfonate
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