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CAS 5451-40-1
2,6-dichloro-9H-purine
登记编号：REGA-012、ABAC-032、NAMOD-011
应用背景（按来源药适应症）
心血管造影剂瑞加诺生诊断剂瑞加诺生造影检查瑞加诺生冠状动脉病变瑞加诺生缺血性心脏病瑞加诺生肺炎瑞加诺生HIV感染硫酸阿巴卡韦艾滋病痴呆综合征硫酸阿巴卡韦肝细胞癌Namodenoson肝硬化Namodenoson非酒精性脂肪性肝炎Namodenoson胰腺癌Namodenoson慢性丙型肝炎Namodenoson
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 瑞加诺生Regadenoson Hydrate | Tier C · 观察 / 贸易 | - |
| 硫酸阿巴卡韦Abacavir Sulfate | Tier C · 观察 / 贸易 | - |
| Namodenoson | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
2,6-dichloro-9H-purine→(2S,3R,4R,5R)-2-acetoxy-5-((benzoyloxy)methyl)tetrahydrofuran-3,4-diyl dibenzoate→(2R,3R,4R,5R)-2-((benzoyloxy)methyl)-5-(2,6-dichloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl dibenzoate→(2R,3R,4S,5R)-2-(6-amino-2-chloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol→N-methyl-1H-pyrazole-4-carboxamide
6-azabicyclo[3.2.0]hept-3-en-7-one→(1S,5R)-6-azabicyclo[3.2.0]hept-3-en-7-one→(1S,5R)-6-tosyl-6-azabicyclo[3.2.0]hept-3-en-7-one→2,6-dichloro-9H-purine→(1S,4R)-4-(2,6-dichloro-9H-purin-9-yl)-N-tosylcyclopent-2-enecarboxamide→(1S,4R)-4-(2,6-dichloro-9H-purin-9-yl)-N-methyl-N-tosylcyclopent-2-enecarboxamide→((1S,4R)-4-(2-chloro-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol
(2R,3S,4R)-2-(hydroxymethyl)-5-methoxytetrahydrofuran-3,4-diol→(2R,3S,4R)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-5-methoxytetrahydrofuran-3,4-diol→(2R,3R,4R)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-5-methoxytetrahydrofuran-3,4-diyl dibenzoate→(2R,3R,4R)-2-(hydroxymethyl)-5-methoxytetrahydrofuran-3,4-diyl dibenzoate→(2S,3S,4R)-3,4-bis(benzoyloxy)-5-methoxytetrahydrofuran-2-carboxylic acid→(3R,4S,5S)-2-methoxy-5-(methoxycarbonyl)tetrahydrofuran-3,4-diyl dibenzoate→(3R,4S,5S)-2-methoxy-5-(methylcarbamoyl)tetrahydrofuran-3,4-diyl dibenzoate→(3R,4S,5S)-2-acetoxy-5-(methylcarbamoyl)tetrahydrofuran-3,4-diyl dibenzoate→2-chloro-N-(3-iodobenzyl)-9H-purin-6-amine→(2R,3R,4S,5S)-2-(2-chloro-6-((3-iodobenzyl)amino)-9H-purin-9-yl)-5-(methylcarbamoyl)tetrahydrofuran-3,4-diyl dibenzoate→2,6-dichloro-9H-purine→(3-iodophenyl)methanamine hydrochloride→Namodenoson
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