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CAS 58-61-7
(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
登记编号：CANG-001、(I)70439-2-a、CORD-001
应用背景（按来源药适应症）
冠状动脉血栓坎格雷洛四钠盐心肌梗塞坎格雷洛四钠盐血栓形成坎格雷洛四钠盐急性冠脉综合征坎格雷洛四钠盐冠状动脉病变坎格雷洛四钠盐动脉粥样硬化坎格雷洛四钠盐巨细胞病毒感染单磷酸阿糖腺苷疱疹病毒感染单磷酸阿糖腺苷淋巴细胞减少症Cordycepin实体瘤Cordycepin淋巴细胞性白血病Cordycepin白血病Cordycepin
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 坎格雷洛四钠盐Cangrelor Tetrasodium | Tier C · 观察 / 贸易 | - |
| 单磷酸阿糖腺苷Vidarabine Monophosphate | Tier C · 观察 / 贸易 | - |
| Cordycepin | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(2R,3R,4R,5R)-2-(6-acetamido-2-((3,3,3-trifluoropropyl)thio)-9H-purin-9-yl)-5-(acetoxymethyl)tetrahydrofuran-3,4-diyl diacetate→(2-chloroethyl)(methyl)sulfane→(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(6-(N-(2-(methylthio)ethyl)acetamido)-2-((3,3,3-trifluoropropyl)thio)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate→(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-((2-(methylthio)ethyl)amino)-2-((3,3,3-trifluoropropyl)thio)-9H-purin-9-yl)tetrahydrofuran-3,4-diol→((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-((2-(methylthio)ethyl)amino)-2-((3,3,3-trifluoropropyl)thio)-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl dihydrogen phosphate→tributylamine (dichloromethylene)bis(phosphonate)→CANG-013→(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol→6-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purine 1-oxide→(Z)-5-amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-N'-hydroxy-1H-imidazole-4-carboximidamide→(2R,3R,4S,5R)-2-(6-amino-2-mercapto-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol hydrate→3-chloro-1,1,1-trifluoropropane→(2R,3R,4S,5R)-2-(6-amino-2-((3,3,3-trifluoropropyl)thio)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol→2'-O-(4-Nitrobenzene-1-sulfonyl)adenosine→2'-O-(3,5-Dinitrobenzene-1-sulfonyl)adenosine→9-(2-O-Acetyl-beta-D-arabinofuranosyl)-9H-purin-6-amine
(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol→1-bromo-3-methyl-1-oxobutan-2-yl acetate→(2R,3S,4S,5R)-2-(6-amino-9H-purin-9-yl)-4-bromo-5-(((2,4,4-trimethyl-5-oxo-1,3-dioxolan-2-yl)oxy)methyl)tetrahydrofuran-3-yl acetate→(2R,3S,4R,5R)-2-(6-amino-9H-purin-9-yl)-4-bromo-5-(hydroxymethyl)tetrahydrofuran-3-ol
(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol→1,1,1-triethoxyethane→((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2-ethoxy-2-methyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol→((2R,3S,4S,5R)-4-acetoxy-5-(6-amino-9H-purin-9-yl)-3-bromotetrahydrofuran-2-yl)methyl acetate→((2S,4R,5R)-4-acetoxy-5-(6-amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl acetate
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Unibest Taizhou GMP-like Site | (2R,3S,4R,5R)-2-(hydroxyMethyl)-5-(6-((2-(Methylthio)ethyl)aMino)-2-((3,3,3-trifluoropropyl)thio)-9H-purin-9-yl)tetrahydrofuran-3,4-diol Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | Phosphonic acid, P,P'-(dichloromethylene)bis-, compd. with N,N-dibutyl-1-butanamine (1:1) Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。