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CAS 76-02-8
2,2,2-trichloroacetyl chloride2,2,2-Tris(chloranyl)ethanoyl chloride
登记编号：ALEC-030、(VII)101438-47-a
应用背景（按来源药适应症）
非小细胞肺癌阿来替尼盐酸盐肺癌阿来替尼盐酸盐乳腺癌Paclitaxel/Encequidar mesylate腺癌Paclitaxel/Encequidar mesylate血管肉瘤Paclitaxel/Encequidar mesylate实体瘤Paclitaxel/Encequidar mesylate胰腺癌紫杉醇非小细胞肺癌紫杉醇霍奇金病紫杉醇精原细胞瘤紫杉醇卵巢癌紫杉醇乳腺癌紫杉醇
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 阿来替尼盐酸盐Alectinib Hydrochloride | Tier B · 提前布局 | 2030 |
| Paclitaxel/Encequidar mesylate | Tier C · 观察 / 贸易 | - |
| 紫杉醇Paclitaxel | Tier B · 提前布局 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
4-(piperidin-4-yl)morpholine→6-cyano-2-(2-(4-ethyl-3-(4-morpholinopiperidin-1-yl)phenyl)propan-2-yl)-1H-indole-3-carboxylic acid→1-(3-bromo-4-ethylphenyl)ethanone→1-(4-ethyl-3-(4-morpholinopiperidin-1-yl)phenyl)ethanone→2-(4-ethyl-3-(4-morpholinopiperidin-1-yl)phenyl)propan-2-ol→methyl 6-cyano-1H-indole-3-carboxylate→methyl 6-cyano-2-(2-(4-ethyl-3-(4-morpholinopiperidin-1-yl)phenyl)propan-2-yl)-1H-indole-3-carboxylate→1H-indole-6-carbonitrile→2,2,2-trichloroacetyl chloride
3(S)-(tert-Butoxycarbonylamino)-2(R)-hydroxy-3-phenylpropionic acid methyl ester→1-(Dimethoxymethyl)naphthalene→(2R,4S,5R)-2-(Naphthalen-1-yl)-4-phenyl-1,3-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl 5-methyl ester→(2R,4S,5R)-3-[(Tert-butoxy)carbonyl]-2-(naphthalen-1-yl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid→(IX)101438-47-a→(2alpha,5beta,7beta,10beta,13alpha)-4,10-Diacetoxy-1,13-dihydroxy-9-oxo-7-(2,2,2-trichloroacetoxy)-5,20-epoxytax-11-en-2-yl benzoate→(2alpha,5beta,7beta,10beta,13alpha)-4-(Acetyloxy)-1,7,10,13-tetrahydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate→2,2,2-Tris(chloranyl)ethanoyl chloride→Acetic acid bromide→(X)101438-47-a→alpha-Chlorobenzaldehyde→(2alpha,5beta,7beta,10beta,13alpha)-4,10-Diacetoxy-13-[[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy]-1-hydroxy-9-oxo-7-(2,2,2-trichloroacetoxy)-5,20-epoxytax-11-en-2-yl benzoate
3(S)-(tert-Butoxycarbonylamino)-2(R)-hydroxy-3-phenylpropionic acid methyl ester→1-(Dimethoxymethyl)naphthalene→(2R,4S,5R)-2-(Naphthalen-1-yl)-4-phenyl-1,3-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl 5-methyl ester→(2R,4S,5R)-3-[(Tert-butoxy)carbonyl]-2-(naphthalen-1-yl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid→(IX)101438-47-a→(2alpha,5beta,7beta,10beta,13alpha)-4,10-Diacetoxy-1,13-dihydroxy-9-oxo-7-(2,2,2-trichloroacetoxy)-5,20-epoxytax-11-en-2-yl benzoate→(2alpha,5beta,7beta,10beta,13alpha)-4-(Acetyloxy)-1,7,10,13-tetrahydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate→2,2,2-Tris(chloranyl)ethanoyl chloride→Acetic acid bromide→(X)101438-47-a→alpha-Chlorobenzaldehyde→(2alpha,5beta,7beta,10beta,13alpha)-4,10-Diacetoxy-13-[[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy]-1-hydroxy-9-oxo-7-(2,2,2-trichloroacetoxy)-5,20-epoxytax-11-en-2-yl benzoate
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | 2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | tert-butyl 6-cyano-2-(2-(4-ethyl-3-iodophenyl)propan-2-yl)-1H-indole-3-carboxylate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | tert-butyl 6-cyano-2-(2-(4-ethyl-3-iodophenyl)propan -2-yl)-1Hindole-3-carboxylate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | tert-butyl 4-(4-ethyl-3-iodophenyl)-4-methyl-3-oxopentanoate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 4-(piperidin-4-yl)morpholine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。