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CAS 866607-35-4
(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate
登记编号：CANA-015
应用背景（按来源药适应症）
终末期肾脏病卡格列净/盐酸二甲双胍心脏和血管疾病卡格列净/盐酸二甲双胍腹主动脉瘤卡格列净/盐酸二甲双胍二型糖尿病卡格列净/盐酸二甲双胍二型糖尿病卡格列净糖尿病肾病卡格列净冠状动脉病变卡格列净糖尿病卡格列净心脏衰竭卡格列净终末期肾脏病卡格列净
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 卡格列净/盐酸二甲双胍Canagliflozin/Metformin Hydrochloride | Tier B · 提前布局 | 2029 |
| 卡格列净Canagliflozin Hemihydrate | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
2-(4-fluorophenyl)thiophene→2-bromothiophene→1-bromo-4-fluorobenzene→5-iodo-2-methylbenzoyl chloride→2-(4-fluorophenyl)-5-(5-iodo-2-methylbenzyl)thiophene→(2R,3R,4S,5R)-2-(acetoxymethyl)-6-oxotetrahydro-2H-pyran-3,4,5-triyl triacetate→(3R,4S,5R,6R)-6-(acetoxymethyl)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-2-hydroxytetrahydro-2H-pyran-3,4,5-triyl triacetate→(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate
2-(4-fluorophenyl)thiophene→2-bromothiophene→1-bromo-4-fluorobenzene→5-iodo-2-methylbenzoyl chloride→2-(4-fluorophenyl)-5-(5-iodo-2-methylbenzyl)thiophene→(2R,3R,4S,5R)-2-(acetoxymethyl)-6-oxotetrahydro-2H-pyran-3,4,5-triyl triacetate→(3R,4S,5R,6R)-6-(acetoxymethyl)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-2-hydroxytetrahydro-2H-pyran-3,4,5-triyl triacetate→(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | (1S)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4methylphenyl]-D-glucitol tetraacetate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。