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CAS 87199-17-5
(4-formylphenyl)boronic acid
登记编号：RUCA-023、ATAZ-012
应用背景（按来源药适应症）
前列腺癌芦卡帕利腹膜癌芦卡帕利卵巢上皮癌芦卡帕利输卵管癌芦卡帕利卵巢癌芦卡帕利去势抵抗性前列腺肿瘤芦卡帕利HIV感染硫酸阿扎那韦/考比司他HIV感染硫酸阿扎那韦获得性免疫缺损综合征硫酸阿扎那韦结核分枝杆菌感染硫酸阿扎那韦一型糖尿病硫酸阿扎那韦
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 芦卡帕利Rucaparib Camsylate | Tier C · 观察 / 贸易 | - |
| 硫酸阿扎那韦/考比司他Atazanavir Sulfate/Cobicistat | Tier C · 观察 / 贸易 | - |
| 硫酸阿扎那韦Atazanavir Sulfate | Tier B · 提前布局 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
2-(2,2-diethoxyethyl)isoindoline-1,3-dione→2-(1,3-dioxoisoindolin-2-yl)acetaldehyde→methyl 6-fluoro-1H-indole-4-carboxylate→methyl 3-(2-(1,3-dioxoisoindolin-2-yl)ethyl)-6-fluoro-1H-indole-4-carboxylate→RUCA-021→RUCA-022→(4-formylphenyl)boronic acid→4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-2-yl)benzaldehyde→(E)-8-fluoro-2-(4-((methylimino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one
2-bromopyridine→4-(pyridin-2-yl)benzaldehyde→tert-butyl hydrazinecarboxylate→tert-butyl (E)-2-(4-(pyridin-2-yl)benzylidene)hydrazine-1-carboxylate→tert-butyl 2-(4-(pyridin-2-yl)benzyl)hydrazine-1-carboxylate→tert-butyl ((S)-1-((R)-oxiran-2-yl)-2-phenylethyl)carbamate→tert-butyl 2-((2S,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazine-1-carboxylate→(2S,3S)-3-amino-4-phenyl-1-(1-(4-(pyridin-2-yl)benzyl)hydrazinyl)butan-2-ol→(S)-2-((methoxycarbonyl)amino)-3,3-dimethylbutanoic acid→(4-formylphenyl)boronic acid→tert-butyl ((2S,3R)-3,4-dihydroxy-1-phenylbutan-2-yl)carbamate→(6R,7S)-7-benzyl-2,2,3,3,11,11-hexamethyl-9-oxo-4,10-dioxa-8-aza-3-siladodecan-6-yl methanesulfonate→(2R,3S)-3-((tert-butoxycarbonyl)amino)-1-hydroxy-4-phenylbutan-2-yl methanesulfonate
2-bromopyridine→4-(pyridin-2-yl)benzaldehyde→tert-butyl hydrazinecarboxylate→tert-butyl (E)-2-(4-(pyridin-2-yl)benzylidene)hydrazine-1-carboxylate→tert-butyl 2-(4-(pyridin-2-yl)benzyl)hydrazine-1-carboxylate→tert-butyl ((S)-1-((R)-oxiran-2-yl)-2-phenylethyl)carbamate→tert-butyl 2-((2S,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazine-1-carboxylate→(2S,3S)-3-amino-4-phenyl-1-(1-(4-(pyridin-2-yl)benzyl)hydrazinyl)butan-2-ol→(S)-2-((methoxycarbonyl)amino)-3,3-dimethylbutanoic acid→(4-formylphenyl)boronic acid→tert-butyl ((2S,3R)-3,4-dihydroxy-1-phenylbutan-2-yl)carbamate→(6R,7S)-7-benzyl-2,2,3,3,11,11-hexamethyl-9-oxo-4,10-dioxa-8-aza-3-siladodecan-6-yl methanesulfonate→(2R,3S)-3-((tert-butoxycarbonyl)amino)-1-hydroxy-4-phenylbutan-2-yl methanesulfonate
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