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CAS 95-54-5
benzene-1,2-diamine
登记编号：TELM-016、BALI-005
应用背景（按来源药适应症）
高血压替米沙坦/苯磺酸氨氯地平/氢氯噻嗪高血压瑞舒伐他汀钙/替米沙坦高脂血症瑞舒伐他汀钙/替米沙坦荨麻疹比拉斯汀过敏性鼻炎比拉斯汀皮炎比拉斯汀瘙痒症比拉斯汀湿疹比拉斯汀变应性结膜炎比拉斯汀高血压苯磺酸氨氯地平/替米沙坦高血压替米沙坦乳腺癌替米沙坦心肌疾病替米沙坦阿尔茨海默病替米沙坦风险降低手段替米沙坦心肌梗塞替米沙坦
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 替米沙坦/苯磺酸氨氯地平/氢氯噻嗪Telmisartan/Amlodipine Besylate/Hydrochlorothiazide | Tier C · 观察 / 贸易 | - |
| 瑞舒伐他汀钙/替米沙坦Rosuvastatin Calcium/Telmisartan | Tier C · 观察 / 贸易 | - |
| 比拉斯汀Bilastine | Tier C · 观察 / 贸易 | - |
| 苯磺酸氨氯地平/替米沙坦Amlodipine Besylate/Telmisartan | Tier C · 观察 / 贸易 | - |
| 替米沙坦Telmisartan | Tier B · 提前布局 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole→o-cresol→4-hydroxy-3-methylbenzaldehyde→4-hydroxy-3-methyl-5-nitrobenzaldehyde→4-methoxy-3-methyl-5-nitrobenzaldehyde→benzene-1,2-diamine→2-(4-methoxy-3-methyl-5-nitrophenyl)-1-methyl-1H-benzo[d]imidazole→2-methyl-4-(1-methyl-1H-benzo[d]imidazol-2-yl)-6-nitroaniline→methyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate→methyl 4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carboxylate
1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole→o-cresol→4-hydroxy-3-methylbenzaldehyde→4-hydroxy-3-methyl-5-nitrobenzaldehyde→4-methoxy-3-methyl-5-nitrobenzaldehyde→benzene-1,2-diamine→2-(4-methoxy-3-methyl-5-nitrophenyl)-1-methyl-1H-benzo[d]imidazole→2-methyl-4-(1-methyl-1H-benzo[d]imidazol-2-yl)-6-nitroaniline→methyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate→methyl 4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carboxylate
benzene-1,2-diamine→piperidine-4-carboxylic acid→2-(piperidin-4-yl)-1H-benzo[d]imidazole→tert-butyl 4-(1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate→2-ethoxyethyl methanesulfonate→tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate→1-(2-ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole→ethyl 2-methyl-2-(4-(2-((methylsulfonyl)oxy)ethyl)phenyl)propanoate→ethyl 2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoate→2-(4-bromophenyl)ethan-1-ol→((1-ethoxy-2-methylprop-1-en-1-yl)oxy)trimethylsilane→ethyl 2-(4-(2-hydroxyethyl)phenyl)-2-methylpropanoate
1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole→o-cresol→4-hydroxy-3-methylbenzaldehyde→4-hydroxy-3-methyl-5-nitrobenzaldehyde→4-methoxy-3-methyl-5-nitrobenzaldehyde→benzene-1,2-diamine→2-(4-methoxy-3-methyl-5-nitrophenyl)-1-methyl-1H-benzo[d]imidazole→2-methyl-4-(1-methyl-1H-benzo[d]imidazol-2-yl)-6-nitroaniline→methyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate→methyl 4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carboxylate
1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole→o-cresol→4-hydroxy-3-methylbenzaldehyde→4-hydroxy-3-methyl-5-nitrobenzaldehyde→4-methoxy-3-methyl-5-nitrobenzaldehyde→benzene-1,2-diamine→2-(4-methoxy-3-methyl-5-nitrophenyl)-1-methyl-1H-benzo[d]imidazole→2-methyl-4-(1-methyl-1H-benzo[d]imidazol-2-yl)-6-nitroaniline→methyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate→methyl 4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carboxylate
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 2-Piperidin-4-yl-1H-benzoimidazole Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | tert-butyl 4-(1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 1-(2-Ethoxy-ethyl)-2-piperidin-4-yl-1H-benzimidazole Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 4-(2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)propan-2-yl)phenethyl 4-methylbenzenesulfonate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。