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Imlunestrant Tosylate
Tier C — Watch / tradeImlunestrant Tosylate
Eli Lilly and Company
Originator
2025
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：ERs
Brand：Inluriyo
Indications (approved)：Breast cancer, Metastatic breast cancer
Regional status
US
Approved
2025-09-25
EU
Approved
2026-01-09
China
Approved
2026-06-17
Japan
Approved
2025-12-22
Synthetic routes & intermediates5 routes
Originator routes × 0Optimised (non-patent) × 5Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 7 · Total yield /
(I)1078735-1-a1208452-88-3(II)1078735-1-a403-43-0(III)1078735-1-a2408771-98-0(IV)1078735-1-a2408771-99-1(V)1078735-1-a2303565-96-8(VI)1078735-1-a2408772-00-7(VII)1078735-1-a503309-11-3(VIII)1078735-1-a2408771-96-8(IX)1078735-1-a—(X)1078735-1-a2408771-97-9(XI)1078735-1-a1642298-59-6(XII)1078735-1-a23147-58-2(XIII)1078735-1-a1443983-86-5API · Imlunestrant Tosylate
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)1078735-1-a | 1208452-88-3 | 4-Bromo-3-chloro-7-methoxyquinoline |
| (II)1078735-1-a | 403-43-0Available | 4-Fluoranylbenzoyl chloride |
| (III)1078735-1-a | 2408771-98-0 | (3-Chloro-7-methoxyquinolin-4-yl)(4-fluorophenyl)methanone |
| (IV)1078735-1-a | 2408771-99-1 | (3-Chloro-7-hydroxyquinolin-4-yl)(4-fluorophenyl)methanone |
| (V)1078735-1-a | 2303565-96-8 | 2-[3-(Fluoromethyl)azetidin-1-yl]ethan-1-ol hydrogen chloride |
| (VI)1078735-1-a | 2408772-00-7 | (3-Chloro-7-hydroxyquinolin-4-yl)(4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl)methanone |
| (VII)1078735-1-a | 503309-11-3 | [2-Fluoro-4-(trifluoromethyl)phenyl]boronic acid |
| (VIII)1078735-1-a | 2408771-96-8 | (4-[2-[3-(Fluoromethyl)azetidin-1-yl]ethoxy]phenyl)[3-[2-fluoro-4-(trifluoromethyl)phenyl]-7-hydroxyquinolin-4-yl]methanone |
| (IX)1078735-1-a | - | 4-[(4-[2-[3-(Fluoromethyl)azetidin-1-yl]ethoxy]phenyl)(hydroxy)methyl]-3-[2-fluoro-4-(trifluoromethyl)phenyl]quinolin-7-ol |
| (X)1078735-1-a | 2408771-97-9 | 5-(4-[2-[3-(Fluoromethyl)azetidin-1-yl]ethoxy]phenyl)-8-(trifluoromethyl)-5H-[1]benzopyrano[4,3-c]quinolin-2-ol |
| (XI)1078735-1-a | 1642298-59-6 | 3-(Fluoromethyl)azetidine hydrogen chloride |
| (XII)1078735-1-a | 23147-58-2 | 1,4-Dioxane-2,5-diol |
| (XIII)1078735-1-a | 1443983-86-5 | 2-[3-(Fluoromethyl)azetidin-1-yl]ethan-1-ol |
OptimisedRoute 2Steps 8 · Total yield /
(I)1078735-2-a82121-05-9(II)1078735-2-a1203579-66-1(III)1078735-2-a1208452-88-3(IV)1078735-2-a459-57-4(V)1078735-2-a2408771-98-0(VI)1078735-2-a403-43-0(VII)1078735-2-a2408771-99-1(VIII)1078735-2-a621-63-6(IX)1078735-2-a—(X)1078735-2-a503309-11-3(XI)1078735-2-a—(XII)1078735-2-a2408772-01-8(XIII)1078735-2-a—(XIV)1078735-2-a,(XIV)1078735-2-b—API · Imlunestrant Tosylate
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)1078735-2-a | 82121-05-9 | 4-Hydroxy-7-methoxyquinoline |
| (II)1078735-2-a | 1203579-66-1 | 3-Chloro-4-hydroxy-7-methoxyquinoline |
| (III)1078735-2-a | 1208452-88-3 | 4-Bromo-3-chloro-7-methoxyquinoline |
| (IV)1078735-2-a | 459-57-4 | (4-Fluorophenyl)methanone |
| (V)1078735-2-a | 2408771-98-0 | (3-Chloro-7-methoxyquinolin-4-yl)(4-fluorophenyl)methanone |
| (VI)1078735-2-a | 403-43-0Available | 4-Fluoranylbenzoyl chloride |
| (VII)1078735-2-a | 2408771-99-1 | (3-Chloro-7-hydroxyquinolin-4-yl)(4-fluorophenyl)methanone |
| (VIII)1078735-2-a | 621-63-6 | 1,1-Diethoxy-2-hydroxyethane |
| (IX)1078735-2-a | - | (3-Chloro-7-hydroxyquinolin-4-yl)[4-(2,2-diethoxyethoxy)phenyl]methanone |
| (X)1078735-2-a | 503309-11-3 | [2-Fluoro-4-(trifluoromethyl)phenyl]boronic acid |
| (XI)1078735-2-a | - | [4-(2,2-Diethoxyethoxy)phenyl][3-[2-fluoro-4-(trifluoromethyl)phenyl]-7-hydroxyquinolin-4-yl]methanone |
| (XII)1078735-2-a | 2408772-01-8 | (4-Fluorophenyl)[3-[2-fluoro-4-(trifluoromethyl)phenyl]-7-hydroxyquinolin-4-yl]methanone |
| (XIII)1078735-2-a | - | 4-[(R)-[4-(2,2-Diethoxyethoxy)phenyl](hydroxy)methyl]-3-[2-fluoro-4-(trifluoromethyl)phenyl]quinolin-7-ol |
| (XIV)1078735-2-a,(XIV)1078735-2-b | - | (5R)-5-[4-(2,2-Diethoxyethoxy)phenyl]-8-(trifluoromethyl)-5H-[1]benzopyrano[4,3-c]quinolin-2-ol |
OptimisedRoute 3Steps 2 · Total yield /
(XIV)1078735-2-a,(XIV)1078735-2-b—(XV)1078735-2-b—(XVI)1078735-2-b—(XVII)1078735-2-b—API · Imlunestrant Tosylate
| Code | CAS No. | Intermediate |
|---|---|---|
| (XIV)1078735-2-a,(XIV)1078735-2-b | - | (5R)-5-[4-(2,2-Diethoxyethoxy)phenyl]-8-(trifluoromethyl)-5H-[1]benzopyrano[4,3-c]quinolin-2-ol |
| (XV)1078735-2-b | - | 2-[4-[(5R)-2-Hydroxy-8-(trifluoromethyl)-5H-[1]benzopyrano[4,3-c]quinolin-5-yl]phenoxy]ethane-1,1-diol |
| (XVI)1078735-2-b | - | 3-(Fluoromethyl)azetidine tosylate |
| (XVII)1078735-2-b | - | [4-[(5R)-2-Hydroxy-8-(trifluoromethyl)-5H-[1]benzopyrano[4,3-c]quinolin-5-yl]phenoxy]acetaldehyde |
OptimisedRoute 4Steps 6 · Total yield /
(I)1078735-3-a1208452-88-3(II)1078735-3-a1071809-52-3(III)1078735-3-a—(IV)1078735-3-a—(V)1078735-3-a503309-11-3(VI)1078735-3-a—(VII)1078735-3-a1443983-86-5(VIII)1078735-3-a—(IX)1078735-3-a—(X)1078735-3-a—API · Imlunestrant Tosylate
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)1078735-3-a | 1208452-88-3 | 4-Bromo-3-chloro-7-methoxyquinoline |
| (II)1078735-3-a | 1071809-52-3 | 4-Fluoro-2,3,5,6-tetradeutero-benzoyl chloride |
| (III)1078735-3-a | - | (3-Chloro-7-methoxyquinolin-4-yl)[4-fluoro-2,3,5,6-tetradeutero-phenyl]methanone |
| (IV)1078735-3-a | - | (3-Chloro-7-hydroxyquinolin-4-yl)[4-fluoro-2,3,5,6-tetradeutero-phenyl]methanone |
| (V)1078735-3-a | 503309-11-3 | [2-Fluoro-4-(trifluoromethyl)phenyl]boronic acid |
| (VI)1078735-3-a | - | [4-Fluoro-2,3,5,6-tetradeutero-phenyl][3-[2-fluoro-4-(trifluoromethyl)phenyl]-7-hydroxyquinolin-4-yl]methanone |
| (VII)1078735-3-a | 1443983-86-5 | 2-[3-(Fluoromethyl)azetidin-1-yl]ethan-1-ol |
| (VIII)1078735-3-a | - | [4-[2-[3-(Fluoromethyl)azetidin-1-yl]ethoxy]-2,3,5,6-tetradeutero-phenyl][3-[2-fluoro-4-(trifluoromethyl)phenyl]-7-hydroxyquinolin-4-yl]methanone |
| (IX)1078735-3-a | - | 4-[[4-[2-[3-(Fluoromethyl)azetidin-1-yl]ethoxy]-2,3,5,6-tetradeutero-phenyl](hydroxy)methyl]-3-[2-fluoro-4-(trifluoromethyl)phenyl]quinolin-7-ol |
| (X)1078735-3-a | - | (±)-5-[4-[2-[3-(Fluoromethyl)azetidin-1-yl]ethoxy]-2,3,5,6-tetradeutero-phenyl]-8-(trifluoromethyl)-5H-[1]benzopyrano[4,3-c]quinolin-2-ol |
OptimisedRoute 5Steps 2 · Total yield /
(I)1078735-4-a28027-17-0(II)1078735-4-a1431364-31-6(III)1078735-4-a503309-11-3(IV)1078735-4-a—API · Imlunestrant Tosylate
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)1078735-4-a | 28027-17-0 | 4-Hydroxy-7-methoxyquinoline-3-carboxylic acid |
| (II)1078735-4-a | 1431364-31-6 | 3-Iodo-7-methoxyquinolin-4-ol |
| (III)1078735-4-a | 503309-11-3 | [2-Fluoro-4-(trifluoromethyl)phenyl]boronic acid |
| (IV)1078735-4-a | - | 3-[2-Fluoro-4-(trifluoromethyl)phenyl]-7-methoxyquinolin-4-ol |
Frequently asked questions
What are the approved indications of Imlunestrant Tosylate?
Approved indications include: Breast cancer, Metastatic breast cancer.
When does the Imlunestrant Tosylate patent expire?
No public expiry year is available for Imlunestrant Tosylate yet; this page updates once verified.
How many synthesis routes are recorded for Imlunestrant Tosylate?
5 synthesis routes are recorded; the shortest is 2 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Imlunestrant Tosylate intermediates?
1 intermediate CAS of Imlunestrant Tosylate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Imlunestrant Tosylate intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-10-22