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CAS 23147-58-2
1,4-Dioxane-2,5-diol
Codes: (XIX)859946-1-a, (XII)1078735-1-a
Application context (from source-drug indications)
Biliary tract cancerTasurgratinibBile duct cancerTasurgratinibSolid tumourTasurgratinibCholangiocarcinomaTasurgratinibBreast cancerTasurgratinibHepatic function declineTasurgratinibBreast cancerImlunestrant TosylateMetastatic breast cancerImlunestrant TosylateMetastatic cancerImlunestrant TosylateOvarian cancerImlunestrant TosylateEndometrial cancerImlunestrant TosylateColorectal cancerImlunestrant Tosylate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Tasurgratinib | Tier C — Watch / trade | - |
| Imlunestrant Tosylate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3,4-Dihydroxybenzaldehyde→1-Bromo-2-methoxyethane→3-Hydroxy-4-(2-methoxyethoxy)benzaldehyde→3-(Benzyloxy)-4-(2-methoxyethoxy)benzaldehyde→Nitrocarbol→2-(Benzyloxy)-1-(2-methoxyethoxy)-4-[(E)-2-nitroethenyl]benzene→6-(2-Methoxyethoxy)-1H-indol-5-ol→N-(4-Chloropyridin-2-yl)acetamide→2-Amino-4-chloropyridine→N-(4-[[6-(2-Methoxyethoxy)-1H-indol-5-yl]oxy]pyridin-2-yl)acetamide→4-[[6-(2-Methoxyethoxy)-1H-indol-5-yl]oxy]pyridin-2-amine→Phenyl methylcarbamate→Aminomethane hydrochloride→Carbonochloridic acid phenyl ester→1,4-Dioxane-2,5-diol→5-[(2-Aminopyridin-4-yl)oxy]-6-(2-methoxyethoxy)-N-methyl-1H-indole-1-carboxamide→4-[1-(tert-Butoxycarbonyl)piperidin-4-yl]benzoic acid→6-(2-Methoxyethoxy)-N-methyl-5-([2-[4-(piperidin-4-yl)benzamido]pyridin-4-yl]oxy)-1H-indole-1-carboxamide→2-Oxidanylethanal
4-Bromo-3-chloro-7-methoxyquinoline→4-Fluoranylbenzoyl chloride→(3-Chloro-7-methoxyquinolin-4-yl)(4-fluorophenyl)methanone→(3-Chloro-7-hydroxyquinolin-4-yl)(4-fluorophenyl)methanone→2-[3-(Fluoromethyl)azetidin-1-yl]ethan-1-ol hydrogen chloride→(3-Chloro-7-hydroxyquinolin-4-yl)(4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl)methanone→[2-Fluoro-4-(trifluoromethyl)phenyl]boronic acid→(4-[2-[3-(Fluoromethyl)azetidin-1-yl]ethoxy]phenyl)[3-[2-fluoro-4-(trifluoromethyl)phenyl]-7-hydroxyquinolin-4-yl]methanone→4-[(4-[2-[3-(Fluoromethyl)azetidin-1-yl]ethoxy]phenyl)(hydroxy)methyl]-3-[2-fluoro-4-(trifluoromethyl)phenyl]quinolin-7-ol→5-(4-[2-[3-(Fluoromethyl)azetidin-1-yl]ethoxy]phenyl)-8-(trifluoromethyl)-5H-[1]benzopyrano[4,3-c]quinolin-2-ol→3-(Fluoromethyl)azetidine hydrogen chloride→1,4-Dioxane-2,5-diol→2-[3-(Fluoromethyl)azetidin-1-yl]ethan-1-ol
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