← Back to patent-cliff list
S-fluoxetine
Tier C — Watch / tradeS-fluoxetine
Sunovion Pharmaceuticals Inc
Originator
-
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：5-HT
Indications (approved)：分离性焦虑, Anxiety, Anxiety disorder
Regional status
US
Phase III
2021-02-09
EU
-
China
-
Japan
-
Synthetic routes & intermediates5 routes
Originator routes × 0Optimised (non-patent) × 5Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 4 · Total yield /
(I)236036-1-a614-16-4(II)236036-1-a165879-80-1(III)236036-1-a130194-42-2(IV)236036-1-a762273-00-7(V)236036-1-a402-45-9(VI)236036-1-a257892-46-9API · S-fluoxetine
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)236036-1-a | 614-16-4 | 3-Oxo-3-phenylpropanenitrile |
| (II)236036-1-a | 165879-80-1 | (3aR,8aS)-2-methyl-2H,3H,3aH,8H,8aH-indeno[1,2-d][1,3,2]oxazaborole |
| (III)236036-1-a | 130194-42-2 | (1S)-3-Amino-1-phenylpropan-1-ol |
| (IV)236036-1-a | 762273-00-7 | tert-butyl N-[(3S)-3-hydroxy-3-phenylpropyl]carbamate |
| (V)236036-1-a | 402-45-9 | 4-(Trifluoromethyl)phenol |
| (VI)236036-1-a | 257892-46-9 | tert-butyl N-[(3S)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]carbamate |
OptimisedRoute 2Steps 4 · Total yield /
(I)236036-2-a498-60-2(II)236036-2-a153681-93-7(III)236036-2-a930-27-8(IV)236036-2-a100-52-7(V)236036-2-a184844-76-6(VI)236036-2-a402-44-8(VII)236036-2-a406945-07-1(VIII)236036-2-a406945-08-2(IX)236036-2-a406945-09-3API · S-fluoxetine
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)236036-2-a | 498-60-2 | 3-Formylfuran |
| (II)236036-2-a | 153681-93-7 | 3-methylidene-2,3-dihydrofuran |
| (III)236036-2-a | 930-27-8 | 3-methylfuran |
| (IV)236036-2-a | 100-52-7Available | Benzaldehyde |
| (V)236036-2-a | 184844-76-6 | (1S)-2-(furan-3-yl)-1-phenylethan-1-ol |
| (VI)236036-2-a | 402-44-8 | 1-fluoro-4-(trifluoromethyl)benzene |
| (VII)236036-2-a | 406945-07-1 | 3-[(2S)-2-phenyl-2-[4-(trifluoromethyl)phenoxy]ethyl]furan |
| (VIII)236036-2-a | 406945-08-2 | (3S)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propanoic acid |
| (IX)236036-2-a | 406945-09-3 | (3S)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propanamide |
OptimisedRoute 3Steps 5 · Total yield /
(I)236036-3-a33401-74-0(II)236036-3-a4850-49-1(III)236036-3-a51699-49-1(IV)236036-3-a156453-52-0(V)236036-3-a50337-25-2(VI)236036-3-a114133-37-8(VII)236036-3-a98-56-6API · S-fluoxetine
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)236036-3-a | 33401-74-0 | Ethyl (3S)-3-hydroxy-3-phenylpropanoate |
| (II)236036-3-a | 4850-49-1 | 1-Phenylpropane-1,3-diol |
| (III)236036-3-a | 51699-49-1 | 1-Phenyl-3-(4-toluenesulphonyloxy)propan-1-ol |
| (IV)236036-3-a | 156453-52-0 | (1S)-3-{[(4-methylbenzene)sulfonyl]oxy}-1-phenylpropan-1-ol |
| (V)236036-3-a | 50337-25-2 | 3-{[(4-methylbenzene)sulfonyl]oxy}-1-phenylpropan-1-one |
| (VI)236036-3-a | 114133-37-8 | (1S)-3-(Methylamino)-1-phenylpropan-1-ol |
| (VII)236036-3-a | 98-56-6 | 1-Chloro-4-(trifluoromethyl)benzene |
OptimisedRoute 4Steps 5 · Total yield /
(I)236036-4-a104-54-1(II)236036-4-a98819-68-2(III)236036-4-a96854-34-1(IV)236036-4-a115290-77-2(V)236036-4-a114133-37-8(VI)236036-4-a98-56-6API · S-fluoxetine
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)236036-4-a | 104-54-1 | 3-Phenyl-2-propen-1-ol |
| (II)236036-4-a | 98819-68-2 | [3(R)-Phenyloxiran-2(R)-yl]methanol |
| (III)236036-4-a | 96854-34-1 | (S)-(-)-1-Phenyl-1,3-propanediol |
| (IV)236036-4-a | 115290-77-2 | (3S)-3-Hydroxy-3-phenylpropyl methanesulfonate |
| (V)236036-4-a | 114133-37-8 | (1S)-3-(Methylamino)-1-phenylpropan-1-ol |
| (VI)236036-4-a | 98-56-6 | 1-Chloro-4-(trifluoromethyl)benzene |
OptimisedRoute 5Steps 6 · Total yield /
(I)236036-8-a100-52-7(II)236036-8-a52324-04-6(III)236036-8-a17190-29-3(IV)236036-8-a5053-63-4(V)236036-8-a130194-42-2(VI)236036-8-a79-22-1(VII)236036-8-a2165777-20-6(VIII)236036-8-a114133-37-8(IX)236036-8-a98-56-6(X)236036-8-a127685-30-7(XI)236036-8-a—API · S-fluoxetine
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)236036-8-a | 100-52-7Available | Benzaldehyde |
| (II)236036-8-a | 52324-04-6 | Ethynamine |
| (III)236036-8-a | 17190-29-3 | 3-Hydroxy-3-phenylpropanenitrile |
| (IV)236036-8-a | 5053-63-4 | 3-Amino-1-phenylpropan-1-ol |
| (V)236036-8-a | 130194-42-2 | (1S)-3-Amino-1-phenylpropan-1-ol |
| (VI)236036-8-a | 79-22-1 | Carbonochloridic acid methyl ester |
| (VII)236036-8-a | 2165777-20-6 | Methyl [(3S)-3-hydroxy-3-phenylpropyl]carbamate |
| (VIII)236036-8-a | 114133-37-8 | (1S)-3-(Methylamino)-1-phenylpropan-1-ol |
| (IX)236036-8-a | 98-56-6 | 1-Chloro-4-(trifluoromethyl)benzene |
| (X)236036-8-a | 127685-30-7 | (3S)-3-Phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine hydrochloride |
| (XI)236036-8-a | - | Methyl [(3S)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]carbamate |
Frequently asked questions
What are the approved indications of S-fluoxetine?
Approved indications include: 分离性焦虑, Anxiety, Anxiety disorder.
When does the S-fluoxetine patent expire?
No public expiry year is available for S-fluoxetine yet; this page updates once verified.
How many synthesis routes are recorded for S-fluoxetine?
5 synthesis routes are recorded; the shortest is 4 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy S-fluoxetine intermediates?
1 intermediate CAS of S-fluoxetine are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for S-fluoxetine intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-10-22