CAS 402-45-9

4-(trifluoromethyl)phenol4-(Trifluoromethyl)phenol

Codes: SELALD-001, (V)236036-1-a, (A)131699-1-a, (V)263642-3-a

Application context (from source-drug indications)

Biliary cirrhosisSeladelpar lysine dihydrateSclerosing cholangitisSeladelpar lysine dihydrateLiver cirrhosisSeladelpar lysine dihydrateHepatic function declineSeladelpar lysine dihydrateFibrosisSeladelpar lysine dihydrateNon-alcoholic steatohepatitisSeladelpar lysine dihydrate分离性焦虑S-fluoxetineAnxietyS-fluoxetineAnxiety disorderS-fluoxetine分离性焦虑R-fluoxetineAnxietyR-fluoxetineAnxiety disorderR-fluoxetine

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Seladelpar lysine dihydrate	Tier C — Watch / trade	-
S-fluoxetine	Tier C — Watch / trade	-
R-fluoxetine	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Seladelpar lysine dihydrateOriginator routesteps: 7total yield: /

4-(trifluoromethyl)phenol→(R)-oxiran-2-ylmethanol→(S)-2-((4-(trifluoromethyl)phenoxy)methyl)oxirane→ethyl 2-(4-mercapto-2-methylphenoxy)acetate→ethyl (R)-2-(4-((2-hydroxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)acetate→ethyl (R)-2-(4-((2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)acetate→(R)-2-(4-((2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)acetic acid→ethyl 2-(o-tolyloxy)acetate→ethyl 2-(4-(chlorosulfonyl)-2-methylphenoxy)acetate→(R)-2-(4-((2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)acetic acid compound with (S)-2,6-diaminohexanoic acid (1:1)

S-fluoxetineOptimised routesteps: 4total yield: /

3-Oxo-3-phenylpropanenitrile→(3aR,8aS)-2-methyl-2H,3H,3aH,8H,8aH-indeno[1,2-d][1,3,2]oxazaborole→(1S)-3-Amino-1-phenylpropan-1-ol→tert-butyl N-[(3S)-3-hydroxy-3-phenylpropyl]carbamate→4-(Trifluoromethyl)phenol→tert-butyl N-[(3S)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]carbamate

R-fluoxetineOptimised routesteps: 4total yield: /

4-(Trifluoromethyl)phenol→3-(Dimethylamino)-1-phenylpropan-1-one→3-(Dimethylamino)-1-phenyl-1-propanol→(3-Chloro-3-phenylpropyl)dimethylamine→N,N-Dimethyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine→cyano(methyl){3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl}amine

R-fluoxetineOptimised routesteps: 6total yield: /

2-Benzoylethyl chloride→3-Chloro-1-phenylpropan-1-ol→3-Chloro-1-phenylpropyl butanoate→(+)-3-Chloro-1(R)-phenylpropan-1-ol→4-(Trifluoromethyl)phenol→(1R)-3-Chloro-1-phenylpropyl 4-(trifluoromethyl)phenyl ether

Intermediates available on this site

No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.