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CAS 104617-51-8
N-(2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)acetamide
Codes: PRAM-002, DEXP-015
Application context (from source-drug indications)
Restless legs syndromePramipexole Dihydrochloride HydrateParkinson's diseasePramipexole Dihydrochloride HydrateManiaPramipexole Dihydrochloride Hydrate快感缺乏Pramipexole Dihydrochloride HydrateDepressionPramipexole Dihydrochloride HydrateMajor depressive disorderPramipexole Dihydrochloride Hydrate肺嗜酸粒细胞增多Dexpramipexole DihydrochlorideAsthmaDexpramipexole DihydrochlorideChronic obstructive pulmonary diseaseDexpramipexole Dihydrochloride高嗜酸性粒细胞综合征Dexpramipexole DihydrochlorideAmyotrophic lateral sclerosisDexpramipexole Dihydrochloride嗜酸粒细胞性哮喘Dexpramipexole Dihydrochloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Pramipexole Dihydrochloride Hydrate | Tier C — Watch / trade | - |
| Dexpramipexole Dihydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
N-(4-oxocyclohexyl)acetamide→N-(2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)acetamide→PRAM-003→(S)-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine→(S)-N-(2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)propionamide
(R)-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine→N-(4-oxocyclohexyl)acetamide→N-(2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)acetamide→DEXP-016→(R)-N-(2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)propionamide
Intermediates available on this site
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