CAS 27514-08-5

N-(4-oxocyclohexyl)acetamide

Codes: PRAM-001, DEXP-014

Application context (from source-drug indications)

Restless legs syndromePramipexole Dihydrochloride HydrateParkinson's diseasePramipexole Dihydrochloride HydrateManiaPramipexole Dihydrochloride Hydrate快感缺乏Pramipexole Dihydrochloride HydrateDepressionPramipexole Dihydrochloride HydrateMajor depressive disorderPramipexole Dihydrochloride Hydrate肺嗜酸粒细胞增多Dexpramipexole DihydrochlorideAsthmaDexpramipexole DihydrochlorideChronic obstructive pulmonary diseaseDexpramipexole Dihydrochloride高嗜酸性粒细胞综合征Dexpramipexole DihydrochlorideAmyotrophic lateral sclerosisDexpramipexole Dihydrochloride嗜酸粒细胞性哮喘Dexpramipexole Dihydrochloride

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Pramipexole Dihydrochloride Hydrate	Tier C — Watch / trade	-
Dexpramipexole Dihydrochloride	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Pramipexole Dihydrochloride HydrateOriginator routesteps: 5total yield: 1.40 g

N-(4-oxocyclohexyl)acetamide→N-(2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)acetamide→PRAM-003→(S)-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine→(S)-N-(2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)propionamide

Dexpramipexole DihydrochlorideOriginator routesteps: 5total yield: /

(R)-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine→N-(4-oxocyclohexyl)acetamide→N-(2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)acetamide→DEXP-016→(R)-N-(2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)propionamide

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