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CAS 1142-20-7
N-[(Benzyloxy)carbonyl]-L-alanine(S)-2-(((benzyloxy)carbonyl)amino)propanoic acid
Codes: Enalapril-011, ANAC-021
Application context (from source-drug indications)
Cardiac and vascular disordersAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHypertensionAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHyperlipidaemiaAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHeart diseaseAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilEssential hypertensionEnalapril Maleate/Folic AcidHeart failureEnalapril MaleateHypertensionEnalapril MaleateMyocardial infarctionEnalapril MaleateAngina pectorisEnalapril MaleateLeft ventricular dysfunctionEnalapril MaleateSolid tumourEnalapril MaleateHypercholesterolaemiaAnacetrapibCardiac and vascular disordersAnacetrapibDyslipidaemiaAnacetrapibAtherosclerosisAnacetrapibHyperlipoproteinaemia type IIAnacetrapibHomozygous familial hypercholesterolaemiaAnacetrapib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Atorvastatin/Hydrochlorothiazide/Aspirin/Enalapril | Tier C — Watch / trade | - |
| Enalapril Maleate/Folic Acid | Tier C — Watch / trade | - |
| Enalapril Maleate | Tier C — Watch / trade | - |
| Anacetrapib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-Hydroxy-4-phenylbutanenitrile→2(R)-Hydroxy-4-phenylbutanenitrile→4-Phenyl-2(R)-(tetrahydropyran-2-yloxy)butanenitrile→4-Phenyl-2(R)-(tetrahydropyran-2-yloxy)butyric acid→N-[(Benzyloxy)carbonyl]-L-alanine→Ethyl (R)-(-)-2-hydroxy-4-phenylbutyrate→4-Phenyl-2(R)-(trifluoromethylsulfonyloxy)butyric acid ethyl ester→L-Alanyl-L-proline tert-butyl ester→N-[1-Ethoxy-1-oxo-4-phenylbutan-2(S)-yl]-L-alanyl-L-proline tert-butyl ester→N-Boc-proline→N-(Benzyloxycarbonyl)-L-alanyl-L-proline tert-butyl ester
2-Hydroxy-4-phenylbutanenitrile→2(R)-Hydroxy-4-phenylbutanenitrile→4-Phenyl-2(R)-(tetrahydropyran-2-yloxy)butanenitrile→4-Phenyl-2(R)-(tetrahydropyran-2-yloxy)butyric acid→N-[(Benzyloxy)carbonyl]-L-alanine→Ethyl (R)-(-)-2-hydroxy-4-phenylbutyrate→4-Phenyl-2(R)-(trifluoromethylsulfonyloxy)butyric acid ethyl ester→L-Alanyl-L-proline tert-butyl ester→N-[1-Ethoxy-1-oxo-4-phenylbutan-2(S)-yl]-L-alanyl-L-proline tert-butyl ester→N-Boc-proline→N-(Benzyloxycarbonyl)-L-alanyl-L-proline tert-butyl ester
2-Hydroxy-4-phenylbutanenitrile→2(R)-Hydroxy-4-phenylbutanenitrile→4-Phenyl-2(R)-(tetrahydropyran-2-yloxy)butanenitrile→4-Phenyl-2(R)-(tetrahydropyran-2-yloxy)butyric acid→N-[(Benzyloxy)carbonyl]-L-alanine→Ethyl (R)-(-)-2-hydroxy-4-phenylbutyrate→4-Phenyl-2(R)-(trifluoromethylsulfonyloxy)butyric acid ethyl ester→L-Alanyl-L-proline tert-butyl ester→N-[1-Ethoxy-1-oxo-4-phenylbutan-2(S)-yl]-L-alanyl-L-proline tert-butyl ester→N-Boc-proline→N-(Benzyloxycarbonyl)-L-alanyl-L-proline tert-butyl ester
2-iodo-4-(trifluoromethyl)aniline→2-amino-5-(trifluoromethyl)benzonitrile→2-iodo-5-(trifluoromethyl)benzonitrile →2-iodo-5-(trifluoromethyl)benzoic acid→[2-iodo-5-(trifluoromethyl)phenyl]methanol →(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one→(4-fluoro-5-isopropyl-2-methoxyphenyl)boronic acid→(4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methanol→2'-(chloromethyl)-4-fluoro-5-isopropyl-2-methoxy-4'-(trifluoromethyl)-1,1'-biphenyl→(S)-2-(((benzyloxy)carbonyl)amino)propanoic acid→N,O-dimethylhydroxylamine→1-bromo-3,5-bis(trifluoromethyl)benzene→1-bromo-3,5-bis(trifluoromethyl)benzene→benzyl (S)-(1-(3,5-bis(trifluoromethyl)phenyl)-1-oxopropan-2-yl)carbamate→benzyl ((1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-1-hydroxypropan-2-yl)carbamate
[2-iodo-5-(trifluoromethyl)phenyl]methanol →(4-fluoro-5-isopropyl-2-methoxyphenyl)boronic acid→(4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methanol→(S)-2-(((benzyloxy)carbonyl)amino)propanoic acid→1-bromo-3,5-bis(trifluoromethyl)benzene→benzyl (S)-(1-(3,5-bis(trifluoromethyl)phenyl)-1-oxopropan-2-yl)carbamate→benzyl ((1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-1-hydroxypropan-2-yl)carbamate→4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-carbaldehyde→(1R,2S)-2-amino-1-(3,5-bis(trifluoromethyl)phenyl)propan-1-ol→(1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-(((E)-(4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methylene)amino)propan-1-ol→(1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-(((4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methyl)amino)propan-1-ol→morpholine→benzyl (S)-(1-morpholino-1-oxopropan-2-yl)carbamate
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