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CAS 1142-20-7
N-[(Benzyloxy)carbonyl]-L-alanine(S)-2-(((benzyloxy)carbonyl)amino)propanoic acid
登记编号：Enalapril-011、ANAC-021
应用背景（按来源药适应症）
心脏和血管疾病阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利高血压阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利高脂血症阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利心脏病阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利原发性高血压马来酸依那普利/叶酸心脏衰竭马来酸依那普利高血压马来酸依那普利心肌梗塞马来酸依那普利心绞痛马来酸依那普利左心室功能不全马来酸依那普利实体瘤马来酸依那普利高胆固醇血症Anacetrapib心脏和血管疾病Anacetrapib血脂障碍Anacetrapib动脉粥样硬化AnacetrapibII型高脂蛋白血症Anacetrapib纯合子家族性高胆固醇血症Anacetrapib
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利Atorvastatin/Hydrochlorothiazide/Aspirin/Enalapril | Tier C · 观察 / 贸易 | - |
| 马来酸依那普利/叶酸Enalapril Maleate/Folic Acid | Tier C · 观察 / 贸易 | - |
| 马来酸依那普利Enalapril Maleate | Tier C · 观察 / 贸易 | - |
| Anacetrapib | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
2-Hydroxy-4-phenylbutanenitrile→2(R)-Hydroxy-4-phenylbutanenitrile→4-Phenyl-2(R)-(tetrahydropyran-2-yloxy)butanenitrile→4-Phenyl-2(R)-(tetrahydropyran-2-yloxy)butyric acid→N-[(Benzyloxy)carbonyl]-L-alanine→Ethyl (R)-(-)-2-hydroxy-4-phenylbutyrate→4-Phenyl-2(R)-(trifluoromethylsulfonyloxy)butyric acid ethyl ester→L-Alanyl-L-proline tert-butyl ester→N-[1-Ethoxy-1-oxo-4-phenylbutan-2(S)-yl]-L-alanyl-L-proline tert-butyl ester→N-Boc-proline→N-(Benzyloxycarbonyl)-L-alanyl-L-proline tert-butyl ester
2-Hydroxy-4-phenylbutanenitrile→2(R)-Hydroxy-4-phenylbutanenitrile→4-Phenyl-2(R)-(tetrahydropyran-2-yloxy)butanenitrile→4-Phenyl-2(R)-(tetrahydropyran-2-yloxy)butyric acid→N-[(Benzyloxy)carbonyl]-L-alanine→Ethyl (R)-(-)-2-hydroxy-4-phenylbutyrate→4-Phenyl-2(R)-(trifluoromethylsulfonyloxy)butyric acid ethyl ester→L-Alanyl-L-proline tert-butyl ester→N-[1-Ethoxy-1-oxo-4-phenylbutan-2(S)-yl]-L-alanyl-L-proline tert-butyl ester→N-Boc-proline→N-(Benzyloxycarbonyl)-L-alanyl-L-proline tert-butyl ester
2-Hydroxy-4-phenylbutanenitrile→2(R)-Hydroxy-4-phenylbutanenitrile→4-Phenyl-2(R)-(tetrahydropyran-2-yloxy)butanenitrile→4-Phenyl-2(R)-(tetrahydropyran-2-yloxy)butyric acid→N-[(Benzyloxy)carbonyl]-L-alanine→Ethyl (R)-(-)-2-hydroxy-4-phenylbutyrate→4-Phenyl-2(R)-(trifluoromethylsulfonyloxy)butyric acid ethyl ester→L-Alanyl-L-proline tert-butyl ester→N-[1-Ethoxy-1-oxo-4-phenylbutan-2(S)-yl]-L-alanyl-L-proline tert-butyl ester→N-Boc-proline→N-(Benzyloxycarbonyl)-L-alanyl-L-proline tert-butyl ester
2-iodo-4-(trifluoromethyl)aniline→2-amino-5-(trifluoromethyl)benzonitrile→2-iodo-5-(trifluoromethyl)benzonitrile →2-iodo-5-(trifluoromethyl)benzoic acid→[2-iodo-5-(trifluoromethyl)phenyl]methanol →(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one→(4-fluoro-5-isopropyl-2-methoxyphenyl)boronic acid→(4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methanol→2'-(chloromethyl)-4-fluoro-5-isopropyl-2-methoxy-4'-(trifluoromethyl)-1,1'-biphenyl→(S)-2-(((benzyloxy)carbonyl)amino)propanoic acid→N,O-dimethylhydroxylamine→1-bromo-3,5-bis(trifluoromethyl)benzene→1-bromo-3,5-bis(trifluoromethyl)benzene→benzyl (S)-(1-(3,5-bis(trifluoromethyl)phenyl)-1-oxopropan-2-yl)carbamate→benzyl ((1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-1-hydroxypropan-2-yl)carbamate
[2-iodo-5-(trifluoromethyl)phenyl]methanol →(4-fluoro-5-isopropyl-2-methoxyphenyl)boronic acid→(4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methanol→(S)-2-(((benzyloxy)carbonyl)amino)propanoic acid→1-bromo-3,5-bis(trifluoromethyl)benzene→benzyl (S)-(1-(3,5-bis(trifluoromethyl)phenyl)-1-oxopropan-2-yl)carbamate→benzyl ((1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-1-hydroxypropan-2-yl)carbamate→4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-carbaldehyde→(1R,2S)-2-amino-1-(3,5-bis(trifluoromethyl)phenyl)propan-1-ol→(1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-(((E)-(4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methylene)amino)propan-1-ol→(1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-(((4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methyl)amino)propan-1-ol→morpholine→benzyl (S)-(1-morpholino-1-oxopropan-2-yl)carbamate
本站可供应的对应中间体
目录暂未收录该靶点的在售中间体 —— 可直接发起询价，需求会进入撮合池。
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