← Back to patent-cliff list
CAS 114772-53-1
4'-methyl-[1,1'-biphenyl]-2-carbonitrile
Codes: TELM-028, FIMA-014, IRBE-009, AZILS-018, AZIL-023
Application context (from source-drug indications)
HypertensionTelmisartan/Amlodipine Besylate/HydrochlorothiazideEssential hypertensionAmlodipine Besylate/Fimasartan PotassiumHypertensionAmlodipine Besylate/Fimasartan PotassiumHypertensionRosuvastatin Calcium/TelmisartanHyperlipidaemiaRosuvastatin Calcium/TelmisartanHypertensionAtorvastatin Calcium Hydrate/IrbesartanHyperlipidaemiaAtorvastatin Calcium Hydrate/IrbesartanHypertensionIrbesartan/TrichlormethiazideHypertensionAzilsartanEssential hypertensionAzilsartanType 2 diabetesAzilsartanObesityAzilsartanDiabetesAzilsartanHypertensionAzilsartan Medoxomil Potassium/ChlorthalidoneEssential hypertensionAzilsartan Medoxomil Potassium/ChlorthalidoneHypertensionAmlodipine Besylate/TelmisartanHypertensionTelmisartanBreast cancerTelmisartanCardiomyopathyTelmisartanAlzheimer's diseaseTelmisartanRisk-reduction measureTelmisartanMyocardial infarctionTelmisartanOesophageal diseaseIrbesartanHypertensionIrbesartanDiabetic nephropathyIrbesartanHypercholesterolaemiaIrbesartanAlbuminuriaIrbesartanType 2 diabetesIrbesartanHypertensionFimasartan Potassium TrihydrateEssential hypertensionFimasartan Potassium TrihydrateHypercholesterolaemiaFimasartan Potassium TrihydrateChronic renal impairmentFimasartan Potassium TrihydrateRenal impairmentFimasartan Potassium TrihydrateHepatic function declineFimasartan Potassium TrihydrateEssential hypertensionAzilsartan Medoxomil PotassiumHypertensionAzilsartan Medoxomil Potassium
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Telmisartan/Amlodipine Besylate/Hydrochlorothiazide | Tier C — Watch / trade | - |
| Amlodipine Besylate/Fimasartan Potassium | Tier C — Watch / trade | - |
| Rosuvastatin Calcium/Telmisartan | Tier C — Watch / trade | - |
| Atorvastatin Calcium Hydrate/Irbesartan | Tier C — Watch / trade | - |
| Irbesartan/Trichlormethiazide | Tier C — Watch / trade | - |
| Azilsartan | Tier C — Watch / trade | - |
| Azilsartan Medoxomil Potassium/Chlorthalidone | Tier C — Watch / trade | - |
| Amlodipine Besylate/Telmisartan | Tier C — Watch / trade | - |
| Telmisartan | Tier B — Position early | - |
| Irbesartan | Tier B — Position early | - |
| Fimasartan Potassium Trihydrate | Tier C — Watch / trade | - |
| Azilsartan Medoxomil Potassium | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
5-(4'-(bromomethyl)-[1,1'-biphenyl]-2-yl)-1-trityl-1H-tetrazole→4'-methyl-[1,1'-biphenyl]-2-carbonitrile→5-(4'-methyl-[1,1'-biphenyl]-2-yl)-1H-tetrazole→5-(4'-methyl-[1,1'-biphenyl]-2-yl)-1-trityl-1H-tetrazole
ethyl 1-aminocyclopentane-1-carboxylate→ethyl pentanimidate→2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one→4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile→4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile→2-(2-methoxyphenyl)-4,4-dimethyl-4,5-dihydrooxazole→p-tolylmagnesium bromide→4,4-dimethyl-2-(4'-methyl-[1,1'-biphenyl]-2-yl)-4,5-dihydrooxazole→4'-methyl-[1,1'-biphenyl]-2-carbonitrile
ethyl 1-aminocyclopentane-1-carboxylate→ethyl pentanimidate→2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one→4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile→4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile→2-(2-methoxyphenyl)-4,4-dimethyl-4,5-dihydrooxazole→p-tolylmagnesium bromide→4,4-dimethyl-2-(4'-methyl-[1,1'-biphenyl]-2-yl)-4,5-dihydrooxazole→4'-methyl-[1,1'-biphenyl]-2-carbonitrile
Intermediates available on this site
No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.